دورية أكاديمية
A wastewater-based epidemiology tool for COVID-19 surveillance in Portugal
| العنوان: | A wastewater-based epidemiology tool for COVID-19 surveillance in Portugal |
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| المؤلفون: | Monteiro, Sílvia, Rente, Daniela, Cunha, Mónica V., Gomes, Manuel Carmo, Marques, Tiago A., Lourenço, Artur B., Cardoso, Eugénia, Álvaro, Pedro, Silva, Marco, Coelho, Norberta, Vilaça, João, Meireles, Fátima, Brôco, Nuno, Carvalho, Marta, Santos, Ricardo |
| المصدر: | Monteiro , S , Rente , D , Cunha , M V , Gomes , M C , Marques , T A , Lourenço , A B , Cardoso , E , Álvaro , P , Silva , M , Coelho , N , Vilaça , J , Meireles , F , Brôco , N , Carvalho , M & Santos , R 2022 , ' A wastewater-based epidemiology tool for COVID-19 surveillance in Portugal ' , Science of the Total Environment , vol. 804 , 150264 . https://doi.org/10.1016/j.scitotenv.2021.150264Test |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | SARS-CoV-2, Wastewater-based epidemiology, COVID-19, Hospital wastewater |
| الوصف: | The presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in wastewater produced interest in its use for sentinel surveillance at a community level and as a complementary approach to syndromic surveillance. With this work, we set the foundations for wastewater-based epidemiology (WBE) in Portugal by monitoring the trends of SARS-CoV-2 RNA circulation in the community, on a nationwide perspective during different epidemiological phases of the pandemic. The Charité assays (E_Sarbecco, RdRP, and N_Sarbecco) were applied to monitor, over 32-weeks (April to December 2020), the dynamics of SARS-CoV-2 RNA at the inlet of five wastewater treatment plants (WWTP), which together serve more than two million people in Portugal. Raw wastewater from three Coronavirus disease 2019 (COVID-19) reference hospitals was also analyzed during this period. In total, more than 600 samples were tested. For the first weeks, detection of SARS-CoV-2 RNA was sporadic, with concentrations varying from 10 3 to 10 5 genome copies per liter (GC/L). Prevalence of SARS-CoV-2 RNA increased steeply by the end of May into late June, mainly in Lisboa e Vale do Tejo region (LVT), during the reopening phase. After the summer, with the reopening of schools in mid-September and return to partial face-to-face work, a pronounced increase of SARS-CoV-2 RNA in wastewater was detected. In the LVT area, SARS-CoV-2 RNA load agreed with reported trends in hotspots of infection. Synchrony between trends of SARS-CoV-2 RNA in raw wastewater and daily new COVID-19 cases highlights the value of WBE as a surveillance tool, particularly after the phasing out of the epidemiological curve and when hotspots of disease re-emerge in the population which might be difficult to spot based solely on syndromic surveillance and contact tracing. This is the first study crossing several epidemiological stages highlighting the long-term use of WBE for SARS-CoV-2. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research-portal.st-andrews.ac.uk/en/researchoutput/a-wastewaterbased-epidemiology-tool-for-covid19-surveillance-in-portugalTest(9abccadb-e431-4ac0-81fd-1f4912abdf6c).html |
| DOI: | 10.1016/j.scitotenv.2021.150264 |
| DOI: | 10.1101/2021.07.21.21260905 |
| الإتاحة: | https://doi.org/10.1016/j.scitotenv.2021.15026410.1101/2021.07.21.21260905Test https://research-portal.st-andrews.ac.uk/en/researchoutput/a-wastewaterbased-epidemiology-tool-for-covid19-surveillance-in-portugalTest(9abccadb-e431-4ac0-81fd-1f4912abdf6c).html https://research-repository.st-andrews.ac.uk/bitstream/10023/25989/1/Monteiro_2022_A_wastewater_based_STOTEN_804_150264_AAM.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.ED8E684F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.scitotenv.2021.150264 |
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