Characterization of the patterns of drug-resistance mutations in newly diagnosed HIV-1 infected patients naïve to the antiretroviral drugs
| العنوان: | Characterization of the patterns of drug-resistance mutations in newly diagnosed HIV-1 infected patients naïve to the antiretroviral drugs |
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| المؤلفون: | Alteri, C, Svicher, V, Gori, C, D'Arrigo, R, Ciccozzi, M, CECCHERINI SILBERSTEIN, F, Selleri, M, Bardacci, S, Giuliani, M, Elia, P, Scognamiglio, P, Balzano, R, Orchi, N, Girardi, E, Perno, Cf, Capobianchi, M, De Carli, G, Galati, V, Grisetti, S, Navarra, A, Nicastri, E, Pittalis, S, Puro, V, Sampaolesi, A, Nurra, G, Zaccarelli, M, Zaniratti, M, Di Carlo, A, De Filippis, A, Brancatella, R, Maggi, T, Gattari, P, Spizzichino, L, Schito, S, Sarmati, L, Battagin, G, Tacconi, L, Gallo, I, Anzalone, E, Pitorri, A, Caterini, A, Barbacci, S |
| المصدر: | BMC Infectious Diseases, Vol 9, Iss 1, p 111 (2009) BMC Infectious Diseases |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | virus strain, Male, genotype, Drug Resistance, Human immunodeficiency virus 1, Etravirine, RNA directed DNA polymerase inhibitor, HIV Infections, Drug resistance, RNA directed DNA polymerase, HIV Antibodies, Cohort Studies, Medical microbiology, binding affinity, Prevalence, HIV Protease Inhibitor, genetics, Viral, Phylogeny, virus mutation, drug effect, article, virus diseases, homosexuality, Middle Aged, cohort analysis, Infectious Diseases, Italy, virus resistance, Cohort, RNA, Viral, Reverse Transcriptase Inhibitors, proteinase, Female, Research Article, medicine.drug, Cohort study, Adult, medicine.medical_specialty, Settore MED/17 - Malattie Infettive, Evolution, proteinase inhibitor, Human immunodeficiency virus antibody, virus RNA, adult, antiviral resistance, codon, DNA polymorphism, female, human, Human immunodeficiency virus 1 infection, major clinical study, male, phylogeny, prevalence, virus carrier, virus load, blood, Human immunodeficiency virus infection, middle aged, molecular evolution, mutation, sequence alignment, statistical model, Drug Resistance, Viral, Evolution, Molecular, HIV Protease Inhibitors, HIV-1, Humans, Logistic Models, Mutation, Sequence Alignment, Biology, lcsh:Infectious and parasitic diseases, medicine, lcsh:RC109-216, Molecular, Virology, Reverse transcriptase, Drug-naïve, Immunology, RNA |
| الوصف: | BackgroundThe transmission of HIV-1 drug-resistant strains in drug naive patients may seriously compromise the efficacy of a first-line antiretroviral treatment. To better define this problem, a study in a cohort of newly diagnosed HIV-1 infected individuals has been conducted. This study is aimed to assess the prevalence and the patterns of the mutations recently associated with transmitted drug resistance in the reverse transcriptase (RT) and in protease (PR) of HIV-1.MethodsPrevalence of transmitted drug resistant strains is determined in 255 newly diagnosed HIV-1 infected patients enrolled in different counselling and testing (CT) centres in Central Italy; the Avidity Index (AI) on the first available serum sample is also used to estimate time since infection. Logistic regression models are used to determine factors associated with infection by drug resistant HIV-1 strains.ResultsThe prevalence of HIV-1 strains with at least one major drug resistance mutation is 5.9% (15/255); moreover, 3.9% (10/255) of patients is infected with HIV nucleoside reverse transcriptase inhibitor (NRTI)-resistant viruses, 3.5% (9/255) with HIV non-NRTI-resistant viruses and 0.4% (1/255) with HIV protease inhibitor (PI)-resistant viruses. Most importantly, almost half (60.0%) of patients carries HIV-1 resistant strains with more than one major drug resistance mutation. In addition, patients who had acquired HIV through homosexual intercourses are more likely to harbour a virus with at least one primary resistance mutation (OR 7.7; 95% CI: 1.7–35.0, P = 0.008).ConclusionThe prevalence of drug resistant HIV-1 strains among newly diagnosed individuals in Central Italy is consistent with the data from other European countries. Nevertheless, the presence of drug-resistance HIV-1 mutations in complex patterns highlights an additional potential risk for public health and strongly supports the extension of wide genotyping to newly diagnosed HIV-1 infected patients. |
| تدمد: | 1471-2334 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076bb96023ad3aa485069d3ac32aa184Test https://doi.org/10.1186/1471-2334-9-111Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....076bb96023ad3aa485069d3ac32aa184 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712334 |
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