المؤلفون: Flanagan, Dustin J., Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J., Gilroy, Kathryn, Raven, Alexander P., Mcgarry, Lynn, Englund, Johanna I., Webb, Anna T., Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C., Ridgway, Rachel A., Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K., Romagnolo, Beatrice, Perret, Christine, Williams, Ann C., Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Jones, E. Yvonne, Ristimäki, Ari, Leedham, Simon J., Fish, Paul V., Vincent, Jean Paul, Katajisto, Pekka, Sansom, Owen J.

المساهمون: Institute of Biotechnology (-2009), University of Helsinki, CAN-PRO - Translational Cancer Medicine Program, Centre of Excellence in Stem Cell Metabolism, Helsinki Institute of Life Science HiLIFE, Institute of Biotechnology, Juha Klefström / Principal Investigator, Research Programs Unit, Department of Pathology, Doctoral Programme in Biomedicine, ATG - Applied Tumor Genomics, Doctoral Programme in Integrative Life Science, HUSLAB, Kari Alitalo / Principal Investigator, Molecular and Integrative Biosciences Research Programme, Biosciences, Nutrient sensing laboratory

مصطلحات موضوعية: STEM-CELLS, BETA-CATENIN, BONE-FORMATION, WNT, MUTATION, HOMEOSTASIS, ACTIVATION, INTESTINE, POLYPOSIS, PATHWAY, 1182 Biochemistry, cell and molecular biology, 3122 Cancers

وصف الملف: application/pdf

العلاقة: Acknowledgements We thank the Core Services and Advanced Technologies at the Cancer Research UK Beatson Institute (C596/A17196 and A31287), and particularly the Biological Services Unit, Histology Service and Molecular Technologies; members of the Sansom and Katajisto laboratories for discussions of the data and manuscript; and BRC Oxford for supplying patient material. O.J.S. and his laboratory members were supported by Cancer Research UK (A28223, A21139, A12481 and A17196). D.J.F. and M.C.H. were supported by the UK Medical Research Council (MR/R017247/1 and MR/J50032X/1, respectively). SpecifiCancer CRUK Grand Challenge (C7932/A29055) is funded by Cancer Research UK and the Mark Foundation for Cancer Research. P.K. and his laboratory members were supported by the Academy of Finland Centre of Excellence MetaStem (266869, 304591 and 320185), the ERC Starting Grant 677809, the Swedish Research Council 2018-03078, the Cancerfonden 190634, the Jane and Aatos Erkko Foundation and the Cancer Foundation Finland. N.P. was supported by the Finnish Cultural Foundation, the Biomedicum Helsinki Foundation, the Orion Research Foundation sr and The Paulo Foundation. P.V.F. was supported by Alzheimer’s Research UK and The Francis Crick Institute. The ARUK UCL Drug Discovery Institute receives its core funding from Alzheimer’s Research UK (520909). The Francis Crick Institute receives its core funding from Cancer Research UK (FC001002), the UK Medical Research Council (FC001002) and the Wellcome Trust (FC001002).; Flanagan , D J , Pentinmikko , N , Luopajärvi , K , Willis , N J , Gilroy , K , Raven , A P , Mcgarry , L , Englund , J I , Webb , A T , Scharaw , S , Nasreddin , N , Hodder , M C , Ridgway , R A , Minnee , E , Sphyris , N , Gilchrist , E , Najumudeen , A K , Romagnolo , B , Perret , C , Williams , A C , Clevers , H , Nummela , P , Lähde , M , Alitalo , K , Hietakangas , V , Hedley , A , Clark , W , Nixon , C , Kirschner , K , Jones , E Y , Ristimäki , A , Leedham , S J , Fish , P V , Vincent , J P , Katajisto , P & Sansom , O J 2021 , ' NOTUM from Apc-mutant cells biases clonal competition to initiate cancer ' , Nature , vol. 594 , no. 7863 , pp. 430-435 . https://doi.org/10.1038/s41586-021-03525-zTest , https://doi.org/10.1038/s41586-021-03525-zTest; ORCID: /0000-0001-9637-6843/work/97056080; ORCID: /0000-0002-3764-5721/work/124844611; ORCID: /0000-0002-2768-8816/work/125976777; 85107302159; 0d60f233-972d-476c-b6db-817ae967b4bb; http://hdl.handle.net/10138/337493Test; 000657239300001

الإتاحة: http://hdl.handle.net/10138/337493Test

المؤلفون: Tian, Ai, Benchabane, Hassina, Wang, Zhenghan, Zimmerman, Chloe, Xin, Nan, Perochon, Jessica, Kalna, Gabriela, Sansom, Owen J., Cheng, Chao, Cordero, Julia B., Ahmed, Yashi

المصدر: PLoS Genetics; 7/14/2017, Vol. 13 Issue 7, p1-37, 37p

مصطلحات موضوعية: CELL proliferation, TRANSCRIPTION factors, COFACTORS (Biochemistry), TUMOR suppressor genes, HOMEOSTASIS, WNT genes, CELLULAR signal transduction, PLANTS

المؤلفون: Elbediwy, Ahmed, Vincent-Mistiaen, Zoé I., Spencer-Dene, Bradley, Stone, Richard K., Boeing, Stefan, Wculek, Stefanie K., Cordero, Julia, Tan, Ee H., Ridgway, Rachel, Brunton, Val G., Sahai, Erik, Gerhardt, Holger, Behrens, Axel, Malanchi, Ilaria, Sansom, Owen J., Thompson, Barry J.

المصدر: Development (09501991); May2016, Vol. 143 Issue 10, p1674-1687, 14p

مصطلحات موضوعية: INTEGRINS, HOMEOSTASIS, SKIN diseases, CARRIER proteins, LABORATORY mice, MAMMALS

المؤلفون: Cordero, Julia B, Ridgway, Rachel A, Valeri, Nicola, Nixon, Colin, Frame, Margaret C, Muller, William J, Vidal, Marcos, Sansom, Owen J

المصدر: EMBO Journal; 7/1/2014, Vol. 33 Issue 13, p1474-1491, 18p

مصطلحات موضوعية: PROTEIN-tyrosine kinases, COLON cancer, DROSOPHILA, EPITHELIUM, HOMEOSTASIS, HYPERPLASIA

المؤلفون: Rosenfeldt, Mathias T., O'Prey, Jim, Morton, Jennifer P., Nixon, Colin, MacKay, Gillian, Mrowinska, Agata, Au, Amy, Rai, Taranjit Singh, Zheng, Liang, Ridgway, Rachel, Adams, Peter D., Anderson, Kurt I., Gottlieb, Eyal, Sansom, Owen J., Ryan, Kevin M.

المصدر: Nature; 12/12/2013, Vol. 504 Issue 7479, p296-300, 5p

مصطلحات موضوعية: P53 antioncogene, TUMOR growth, AUTOPHAGY, HOMEOSTASIS, LABORATORY mice, ADENOCARCINOMA, GENETICS, MAMMALS

المؤلفون: Cordero, Julia B, Stefanatos, Rhoda K, Scopelliti, Alessandro, Vidal, Marcos, Sansom, Owen J

المصدر: EMBO Journal; 10/3/2012, Vol. 31 Issue 19, p3901-3917, 17p, 1 Color Photograph, 1 Diagram, 7 Graphs

مصطلحات موضوعية: DROSOPHILA, STEM cells, PROGENITOR cells, REGENERATION (Biology), EPITHELIAL cells, PROTEINS, HOMEOSTASIS

المؤلفون: Myant, Kevin, Sansom, Owen J. o.sansom@beatson.gla.ac.uk

المصدر: Experimental Cell Research. Nov2011, Vol. 317 Issue 19, p2725-2731. 7p.

مصطلحات موضوعية: *COLON cancer, *TRANSCRIPTION factors, *HOMEOSTASIS, *PROTEIN-protein interactions, *CARCINOGENESIS, *WNT proteins, *MYC proteins

المؤلفون: Shorning, Boris Y., Zabkiewicz, Joanna, McCarthy, Afshan, Pearson, Helen B., Winton, Douglas J., Sansom, Owen J., Ashworth, Alan, Clarke, Alan R.

المصدر: PLoS ONE; 2009, Vol. 4 Issue 1, p1-8, 8p, 4 Color Photographs

مصطلحات موضوعية: EXFOLIATIVE cytology, SMALL intestine, TUMOR suppressor genes, TUMOR suppressor proteins, HOMEOSTASIS, CELL differentiation, MICE behavior, LABORATORY mice, RECOMBINANT antibodies, LIGANDS (Biochemistry), NOTCH genes, NOTCH proteins, CELL cycle

المؤلفون: Marsh, Victoria, Winton, Douglas J., Williams, Geraint T., Dubois, Nicole, .Trumpp, Andreas, Sansom, Owen J., Clarke, Alan R.

المصدر: Nature Genetics; Dec2008, Vol. 40 Issue 12, p1436-1444, 9p, 6 Color Photographs, 4 Graphs

مصطلحات موضوعية: ADENOMA, GENETIC mutation, HOMEOSTASIS, TUMOR suppressor proteins, STEM cells

المؤلفون: Sansom, Owen J.¹ o.sansom@beatson.gla.ac.uk, Meniel, Valerie², Wilkins, Julie A.¹, Cole, Alicia M.¹, Oien, Karin A.¹, Marsh, Victoria², Jamieson, Thomas J.¹, Guerra, Carmen³, Gabrielle H. Ashton¹, Barbacid, Mariano³, Clarke, Alan R.²

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 9/19/2006, Vol. 103 Issue 38, p14122-14127. 6p. 2 Color Photographs, 1 Graph.

مصطلحات موضوعية: *COLON cancer, *PHENOTYPES, *TUMOR growth, *TRANSFORMING growth factors, *HOMEOSTASIS