التفاصيل البيبلوغرافية
| العنوان: |
Interleukin-7 Influences FOXP3+CD4+ Regulatory T Cells Peripheral Homeostasis. |
| المؤلفون: |
Simonetta, Federico, Gestermann, Nicolas, Martinet, Kim Zita, Boniotto, Michele, Tissières, Pierre, Seddon, Benedict, Bourgeois, Christine |
| المصدر: |
PLoS ONE; May2012, Vol. 7 Issue 5, p1-9, 9p |
| مصطلحات موضوعية: |
INTERLEUKIN-7, T cells, CELLULAR control mechanisms, HOMEOSTASIS, IMMUNE response, AUTOIMMUNITY |
| مستخلص: |
Mechanisms governing peripheral CD4+ FOXP3+ regulatory T cells (Treg) survival and homeostasis are multiple suggesting tight and complex regulation of regulatory T cells homeostasis. Some specific factors, such as TGF-β, interleukin-2 (IL-2) and B7 costimulatory molecules have been identified as essentials for maintenance of the peripheral Treg compartment. Conversely, Treg dependency upon classical T cell homeostatic factors such as IL-7 is still unclear. In this work, we formally investigated the role of IL-7 in Treg homeostasis in vivo in murine models. We demonstrated that IL-7 availability regulated the size of peripheral Treg cell pool and thus paralleled the impact of IL-7 on conventional T cell pool. Moreover, we showed that IL-7 administration increased Treg cell numbers by inducing thymic-independent Treg peripheral expansion. Importantly the impact of IL-7 on Treg expansion was detected whether conventional T cells were present or absent as IL-7 directly participates to the peripheral expansion of Treg after adoptive transfer into lymphopenic hosts. Our results definitively identify IL-7 as a central factor contributing to Treg peripheral homeostasis, thus reassembling Treg to other T cell subsets in respect of their need for IL-7 for their peripheral maintenance. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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