Gatekeepers of the fetus: Characterization of placental macrophages
| العنوان: | Gatekeepers of the fetus: Characterization of placental macrophages |
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| المؤلفون: | Carolyn B. Coyne, Christina Megli |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Placenta, Innate Immunity and Inflammation, Immunology, Biology, Insights, Article, Infectious Disease and Host Defense, 03 medical and health sciences, Fetus, 0302 clinical medicine, Immune system, Pregnancy, medicine, Humans, Immunology and Allergy, Folate Receptor 2, Macrophages, Mucosal Immunology, HLA-DR Antigens, Cell biology, Pregnancy Trimester, First, 030104 developmental biology, medicine.anatomical_structure, Matrix Metalloproteinase 9, 030220 oncology & carcinogenesis, embryonic structures, Female |
| الوصف: | Hofbauer cells are primitive placental macrophages with a unique phenotype and role in fetal defense. Using transcriptomic and proteomic data, Thomas et al. analyze human first-trimester placental macrophages and delineate markers that identify them. They also reveal that Hofbauer cells have microbicidal capacity, providing the fetus with an additional layer of protection from certain microbes. Hofbauer cells (HBCs) are a population of macrophages found in high abundance within the stroma of the first-trimester human placenta. HBCs are the only fetal immune cell population within the stroma of healthy placenta. However, the functional properties of these cells are poorly described. Aligning with their predicted origin via primitive hematopoiesis, we find that HBCs are transcriptionally similar to yolk sac macrophages. Phenotypically, HBCs can be identified as HLA-DR−FOLR2+ macrophages. We identify a number of factors that HBCs secrete (including OPN and MMP-9) that could affect placental angiogenesis and remodeling. We determine that HBCs have the capacity to play a defensive role, where they are responsive to Toll-like receptor stimulation and are microbicidal. Finally, we also identify a population of placenta-associated maternal macrophages (PAMM1a) that adhere to the placental surface and express factors, such as fibronectin, that may aid in repair. Graphical Abstract |
| تدمد: | 1540-9538 0022-1007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1842544117cc8092f419d8d6bbcef02dTest https://doi.org/10.1084/jem.20202071Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1842544117cc8092f419d8d6bbcef02d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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