التفاصيل البيبلوغرافية
| العنوان: |
Liver Fibrosis and Steatosis in Virally Suppressed HIV-Infected Patients with Cytomegalovirus Seropositivity. |
| المؤلفون: |
Jasirwan, Chyntia Olivia Maurine, Wibowo, Adik, Sjaaf, Amal C., Aprilicia, Gita, Purnamasari, Dyah, Yunihastuti, Evy, Gani, Rino Alvani |
| المصدر: |
Indonesian Journal of Gastroenterology, Hepatology & Digestive Endoscopy; Dec2021, Vol. 22 Issue 3, p180-187, 8p |
| مصطلحات موضوعية: |
FATTY liver, HIV, FIBROSIS, LIVER, FATTY degeneration, SEROCONVERSION |
| الملخص (بالإنجليزية): |
Background: Cytomegalovirus (CMV) is a human herpesvirus common in people with human immunodeficiency virus (HIV). In a patient with immunocompetence, long periodic asymptomatic CMV might affect to develop the abnormal liver function and contribute to non-AIDS defining morbidity, including chronic liver disease. This study aims to know the prevalence of liver fibrosis and steatosis in virally suppressed HIV infected patients with CMV reactive and summarize the correlation of clinical presentation with liverfibrosis and steatosis in these subjects. Method: A cross-sectional study in HIV Integrated Care Unit, Cipto Mangunkusumo Hospital, was conducted from April 2019 until June 2020. Subjects enrolled in this study were suppressed HIV patients aged between 30-40 years with positive IgG CMVand already using stable ARTfor at least one year. Transient elastography measured the liver stiffness. Patients with liver stiffness above 7 kPa were defined as having significant liver fibrosis. In addition, Spearman correlation was conducted to evaluate the correlation of clinical presentation of subjects related to liver fibrosis and steatosis. Results: A total of subjects was included in this study. Dominantly male (62.5%) with average age 38 ± 4.68 years. The median amount of CMV DNA was 466 (17-21284) copy/mL. Significant Fibrosis was found in 17/80 (21%) subjects. In this study, clinical parameters correlated with liver fibrosis were insulin, glucose fasting, Homa IR, triglyceride, HDL, and platelet. A medium positive correlation was found in insulin, and Homa IR, with coefficient correlation for insulin, was r = 0.475, p < 0.001; and coefficient correlation for Homa IR was r = 0 .487, p < 0.001. Conclusion: The prevalence of liver fibrosis was 21% in these subjects. In addition, insulin and Homa IR had a positive correlation with increasing liver fibrosis. [ABSTRACT FROM AUTHOR] |
| Abstract (Indonesian): |
Latar belakang: Cytomegalovirus (CMV) adalah virus herpes manusia yang umum terjadi pada pasien human immunodeficiency virus (HIV). Pada pasien dengan imunokompeten, infeksi CMV dapat terjadi asimtomatik jangka panjang yang dapat menyebabkan gangguan fungsi hati dan menimbulkan morbiditas non-AIDS bersama penyakit hati kronik lainnya. Penelitian ini bertujuan untuk mengetahui prevalensi fibrosis dan steatosis hati pada pasien terinfeksi HIV dengan kadar virus sudah ditekan dengan antivirus, namun kondisi infeksi CMV reaktif, serta mengetahui korelasi berbagai manifestasi klinis dengan fibrosis hati pada subjek tersebut. Metode: Studi potong lintang di Unit Pelayanan Terpadu HIV, Rumah Sakit Cipto Mangunkusumo, dilakukan antara April 2019 hingga Juni 2020. Subyek pada penelitian ini adalah pasien HIV yang kadar virusnya telah ditekan dengan antivirus, berusia antara 30-40 tahun dengan IgG CMV positif dan sudah menggunakan antiretroviral therapy (ART) stabil setidaknya selama satu tahun. Elastografi transien berfungsi mengukur kekakuan hati. Pasien dengan kekakuan hati di atas 7 kPa didefinisikan memiliki fibrosis hati yang signifikan. Selain itu, korelasi Spearman dilakukan untuk mengevaluasi korelasi presentasi klinis subyek penelitian dengan fibrosis dan steatosis hati. Hasil: Sebanyak 80 pasien dilibatkan dalam penelitian ini. Didominasi laki-laki (62,5%) dengan usia rata-rata 38 ± 4,68 tahun. Jumlah rata-rata DNA CMV adalah 466 (17-21284) copy/mL. Fibrosis signifikan ditemukan pada 17/80 (21%) pasien. Pada penelitian ini, parameter klinis yang berhubungan dengan fibrosis hati adalah insulin, glukosa puasa, Homa IR, trigliserida, HDL, dan trombosit. Korelasi positif sedang ditemukan pada insulin, dan Homa IR, dengan koefisien korelasi untuk insulin, adalah r = 0,475, p-value < 0,001; dan koefisien korelasi untukHomaIR adalah r = 0,487, p < 0,001. Simpulan: Prevalensi fibrosis hati adalah 21% pada subjek ini. Insulin dan Homa IR memiliki korelasi positif dengan peningkatan fibrosis hati. [ABSTRACT FROM AUTHOR] |
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Copyright of Indonesian Journal of Gastroenterology, Hepatology & Digestive Endoscopy is the property of Indonesian Society of Gastroenterology/Assoc for the Study of the Liver/Soc. for Digestive Endoscopy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
