Deciphering the Enigma of the Histone H2A.Z-1/H2A.Z-2 Isoforms: Novel Insights and Remaining Questions
| العنوان: | Deciphering the Enigma of the Histone H2A.Z-1/H2A.Z-2 Isoforms: Novel Insights and Remaining Questions |
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| المؤلفون: | Deanna Dryhurst, Cameron D. Mackereth, Iva B. Zovkic, Katrina V. Good, Ciro Rivera Casas, Perry L. Howard, Bohyun Kim, Heddy Soufari, Andrew J. Kennedy, Melissa E. Freeman, Manjinder S. Cheema, Jeffrey Shabanowitz, Donald F. Hunt, Gilda Stefanelli, Juan Ausió, Connor O'Sullivan, Kristine E. Zengeler, Jose Maria Eirin Lopez |
| المصدر: | Cells Cells, Vol 9, Iss 1167, p 1167 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Gene isoform, Male, DNA damage, Review, Chromosome segregation, Histones, 03 medical and health sciences, Mice, Transcription (biology), Histone H2A, Gene expression, evolution, Animals, Humans, Protein Isoforms, Amino Acid Sequence, lcsh:QH301-705.5, development, Phylogeny, Genetics, chemistry.chemical_classification, H2A.Z-1 and H2A.Z-2, 030102 biochemistry & molecular biology, biology, Cell Cycle, Osmolar Concentration, Brain, General Medicine, DNA Methylation, NMR, spermatogenesis, Chromatin, Amino acid, Nucleosomes, replication dependent (RD) and replication independent (RI) histone variants, 030104 developmental biology, Histone, chemistry, lcsh:Biology (General), Liver, biology.protein, transcription, Chickens |
| الوصف: | The replication independent (RI) histone H2A.Z is one of the more extensively studied variant members of the core histone H2A family, which consists of many replication dependent (RD) members. The protein has been shown to be indispensable for survival, and involved in multiple roles from DNA damage to chromosome segregation, replication, and transcription. However, its functional involvement in gene expression is controversial. Moreover, the variant in several groups of metazoan organisms consists of two main isoforms (H2A.Z-1 and H2A.Z-2) that differ in a few (3–6) amino acids. They comprise the main topic of this review, starting from the events that led to their identification, what is currently known about them, followed by further experimental, structural, and functional insight into their roles. Despite their structural differences, a direct correlation to their functional variability remains enigmatic. As all of this is being elucidated, it appears that a strong functional involvement of isoform variability may be connected to development. |
| اللغة: | English |
| تدمد: | 2073-4409 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3200f4144c47e8a7ea6b4ce607c7863bTest http://europepmc.org/articles/PMC7290884Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3200f4144c47e8a7ea6b4ce607c7863b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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