دورية أكاديمية
The transcriptional repression activity of STAF65γ is facilitated by promoter tethering and nuclear import of class IIa histone deacetylases
| العنوان: | The transcriptional repression activity of STAF65γ is facilitated by promoter tethering and nuclear import of class IIa histone deacetylases |
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| المؤلفون: | Hsieh, Feng-Shu, Chen, Nai-Tzu, Yao, Ya-Li, Wang, Shi-Yun, Chen, Jeremy J.W., Lai, Chien-Chen, Yang, Wen-Ming |
| سنة النشر: | 2014 |
| المجموعة: | National Chung Hsing University Institutional Repository - NCHUIR / 國立中興大學 |
| مصطلحات موضوعية: | Histone deacetylases, Lung adenocarcinoma, STAF65γ, Transcriptional regulation, YY1, Active Transport, Cell Nucleus, Adenocarcinoma, Adult, Aged, Cell Cycle, Cell Line, Tumor, Female, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms, Male, Middle Aged, Prognosis, Repressor Proteins, Sumoylation, Trans-Activators, YY1 Transcription Factor, Promoter Regions, Genetic, Transcription |
| الوصف: | Aberrant expression levels of transcriptional regulators result in alterations in transcriptional control. STAF65γ is a structural subunit of the GCN5 transcriptional co-activator complex. Reports showed that STAF65γ is highly expressed in several human cancer cells, but the consequences of this aberrant expression pattern remain elusive. Here, we show that the STAF65γ protein is highly expressed in lung adenocarcinoma patients and high levels of STAF65γ correlate with poor prognosis. High levels of STAF65γ cause repression of the c-Myc oncogene through physical association with transcription factor YY1 and co-repressors HDACs. Physical interactions between STAF65γ and class IIa HDACs facilitate nuclear enrichment and regulate the assembly of HDAC complexes. Moreover, SUMOylation of STAF65γ is necessary for maintaining the co-repressor complex containing YY1 and class IIa HDACs at the promoter. Our findings reveal a distinct role of STAF65γ in nuclear import, transcriptional repression, and cell cycle regulation at high levels of expression, which is associated with poor clinical outcomes of lung adenocarcinoma. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 18749399 |
| العلاقة: | #PLACEHOLDER_PARENT_METADATA_VALUE#; Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1839, Issue 7, Page(s) 579-591.; http://hdl.handle.net/11455/86398Test |
| DOI: | 10.1016/j.bbagrm.2014.05.007 |
| الإتاحة: | https://doi.org/10.1016/j.bbagrm.2014.05.007Test http://hdl.handle.net/11455/86398Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.247E9A |
| قاعدة البيانات: | BASE |
| تدمد: | 18749399 |
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| DOI: | 10.1016/j.bbagrm.2014.05.007 |