التفاصيل البيبلوغرافية
| العنوان: |
Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin. |
| المؤلفون: |
Jiang, Wei I.1, De Belly, Henry1,2, Bingying Wang1, Wong, Andrew1, Minseo Kim1, Oh, Fiona1, DeGeorge, Jason1, Xinya Huang3, Shouhong Guang3, Weiner, Orion D.1,2, Ma, Dengke K.1,4,5 dengke.ma@ucsf.edu |
| المصدر: |
Science Advances. 1/26/2024, Vol. 10 Issue 4, p1-12. 12p. |
| مصطلحات موضوعية: |
*LONGEVITY, *TETRASPANIN, *THERMAL stresses, *HISTONE acetyltransferase, *CAENORHABDITIS elegans, *PSILOCYBIN |
| مستخلص: |
Early-life stress experiences can produce lasting impacts on organismal adaptation and fitness. How transient stress elicits memory-like physiological effects is largely unknown. Here, we show that early-life thermal stress strongly up-regulates tsp-1, a gene encoding the conserved transmembrane tetraspanin in C. elegans. TSP-1 forms prominent multimers and stable web-like structures critical for membrane barrier functions in adults and during aging. Increased TSP-1 abundance persists even after transient early-life heat stress. Such regulation requires CBP-1, a histone acetyltransferase that facilitates initial tsp-1 transcription. Tetraspanin webs form regular membrane structures and mediate resilience-promoting effects of early-life thermal stress. Gain-of-function TSP-1 confers marked C. elegans longevity extension and thermal resilience in human cells. Together, our results reveal a cellular mechanism by which early-life thermal stress produces long-lasting memory-like impact on organismal resilience and longevity. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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