التفاصيل البيبلوغرافية
| العنوان: |
Survival outcomes and molecular drivers of testicular cancer in hispanic men. |
| المؤلفون: |
Rezaee, Michael E.1 (AUTHOR), Elias, Roy1,2 (AUTHOR), Li, Howard L.1 (AUTHOR), Agrawal, Pranjal1 (AUTHOR), Pallauf, Maximilian1,3 (AUTHOR), Enikeev, Dmitry4 (AUTHOR), Ged, Yasser2 (AUTHOR), Eggener, Scott5 (AUTHOR), Singla, Nirmish1,2 (AUTHOR) nsingla2@jhmi.edu |
| المصدر: |
Urologic Oncology. Sep2024, Vol. 42 Issue 9, p293.e1-293.e7. 1p. |
| مصطلحات موضوعية: |
*TESTICULAR cancer, *CANCER patients, *SURVIVAL rate, *GERM cell tumors, *SOMATIC mutation, *PROPORTIONAL hazards models, *TRAFFIC accidents |
| مستخلص: |
• Hispanic men are more likely to present with non-seminomatous germ cell tumor (NSGCT), at a younger age, and with more advanced disease. • Hispanic men with NSGCT experience significantly worse survival compared to other race/ethnic groups. • Identification of molecular drivers responsible for differences in biologic risk between race/ethnic groups is limited by currently available repositories with small sample sizes. To examine survival outcomes and molecular drivers in testis cancer among Hispanic men using a large national sample and molecular database. We reviewed the SEER registry for testicular cancer from 2000 to 2020. Cox proportional hazards models were used to examine the relationship between race/ethnicity and cancer-specific survival (CSS) by tumor type (seminoma vs. nonseminomatous germ cell tumors [NSGCT]). All models were adjusted for demographic, socioeconomic, and treatment variables. We accessed somatic mutations for testicular cancers through AACR Project GENIE v13.1 and compared mutational frequencies by ethnicity. Our cohort consisted of 43,709 patients (23.3% Hispanic) with median follow-up 106 months (interquartile range: 45-172). Compared to Non-Hispanic Whites (NWH), Hispanics presented at a younger age but with more advanced disease. Hispanics experienced worse CSS for NSGCT (HR 1.7, 95% CI: 1.5-2.0, P < 0.01) but not seminoma. Somatic mutation data was available for 699 patients. KIT and KRAS mutations occurred in 24.2% and 16.9% of seminoma patients (n = 178), respectively. TP53 and KRAS mutations occurred in 12.1% and 7.9% of NSGCT patients (n = 521), respectively. No differences in mutational frequencies were observed between ethnic groups. There was significant heterogeneity in primary ancestral group for Hispanic patients with available data (n = 53); 14 (26.4%) patients had primary Native American ancestry and 30 (56.6%) had primary European ancestry. Cancer-specific survival is worse for Hispanic men with non-seminoma of the testicle. Somatic mutation analysis suggests no differences by ethnicity, though genetic ancestry is heterogeneous among patients identifying as Hispanic. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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