دورية أكاديمية
Long-Term Overconsumption of Fat and Sugar Causes a Partially Reversible Pre-inflammatory Bowel Disease State
| العنوان: | Long-Term Overconsumption of Fat and Sugar Causes a Partially Reversible Pre-inflammatory Bowel Disease State |
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| المؤلفون: | Arnone, Djésia, Vallier, Marie, Hergalant, Sébastien, Chabot, Caroline, Ndiaye, Ndeye, Coumba, Moulin, David, Aignatoaei, Anda-Maria, Alberto, Jean-Marc, Louis, Huguette, Boulard, Olivier, Mayeur, Camille, Dreumont, Natacha, Peuker, Kenneth, Strigli, Anne, Zeissig, Sebastian, Hansmannel, Franck, Chamaillard, Matthias, Kökten, Tunay, Peyrin-Biroulet, Laurent |
| المساهمون: | Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Max-Planck-Institut, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Ingénierie, Biologie et Santé en Lorraine (IBSLor), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 (PHYCELL), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Technische Universität Dresden = Dresden University of Technology (TU Dresden), Service d'Hépato-gastro-entérologie CHRU Nancy, ANR-15-IDEX-0004,LUE,Isite LUE(2015) |
| المصدر: | EISSN: 2296-861X ; Frontiers in Nutrition ; https://hal.univ-lorraine.fr/hal-03430881Test ; Frontiers in Nutrition, 2021, 8, pp.758518. ⟨10.3389/fnut.2021.758518⟩ |
| بيانات النشر: | HAL CCSD Frontiers Media S.A. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | diet-induced, IBD-inflammatory bowel diseases, colitis, gut homeostasis, high-fat high-sucrose diet, Inflammatory Bowel Disease, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Nutrition appears to be an important environmental factor involved in the onset of inflammatory bowel diseases (IBD) through yet poorly understood biological mechanisms. Most studies focused on fat content in high caloric diets, while refined sugars represent up to 40% of caloric intake within industrialized countries and contribute to the growing epidemics of inflammatory diseases. Herein we aim to better understand the impact of a high-fat-high-sucrose diet on intestinal homeostasis in healthy conditions and the subsequent colitis risk. We investigated the early events and the potential reversibility of high caloric diet-induced damage in mice before experimental colitis. C57BL/6 mice were fed with a high-fat or high-fat high-sucrose or control diet before experimental colitis. In healthy mice, a high-fat high-sucrose diet induces a pre-IBD state characterized by gut microbiota dysbiosis with a total depletion of bacteria belonging to Barnesiella that is associated with subclinical endoscopic lesions. An overall down-regulation of the colonic transcriptome converged with broadly decreased immune cell populations in the mesenteric lymph nodes leading to the inability to respond to tissue injury. Such in-vivo effects on microbiome and transcriptome were partially restored when returning to normal chow. Long-term consumption of diet enriched in sucrose and fat predisposes mice to colitis.This enhanced risk is preceded by gut microbiota dysbiosis and transcriptionalreprogramming of colonic genes related to IBD. Importantly, diet-induced transcriptome and microbiome disturbances are partially reversible after switching back to normal chow with persistent sequelae that may contribute to IBD predisposition in the general population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34869528; hal-03430881; https://hal.univ-lorraine.fr/hal-03430881Test; https://hal.univ-lorraine.fr/hal-03430881/documentTest; https://hal.univ-lorraine.fr/hal-03430881/file/fnut-08-758518.pdfTest; PUBMED: 34869528; PUBMEDCENTRAL: PMC8637418 |
| DOI: | 10.3389/fnut.2021.758518 |
| الإتاحة: | https://doi.org/10.3389/fnut.2021.758518Test https://hal.univ-lorraine.fr/hal-03430881Test https://hal.univ-lorraine.fr/hal-03430881/documentTest https://hal.univ-lorraine.fr/hal-03430881/file/fnut-08-758518.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.FDDC3BF4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fnut.2021.758518 |
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