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Cartilage Repair Activity during Joint-Preserving Treatment May Be Accompanied by Osteophyte Formation

التفاصيل البيبلوغرافية
العنوان: Cartilage Repair Activity during Joint-Preserving Treatment May Be Accompanied by Osteophyte Formation
المؤلفون: Mylène P. Jansen, Simon C. Mastbergen, Fiona E. Watt, Elske J. Willemse, Tonia L. Vincent, Sander Spruijt, Pieter J. Emans, Roel J. H. Custers, Ronald J. van Heerwaarden, Floris P. J. G. Lafeber
المصدر: Applied Sciences, Vol 11, Iss 15, p 7156 (2021)
بيانات النشر: MDPI AG, 2021.
سنة النشر: 2021
المجموعة: LCC:Technology
LCC:Engineering (General). Civil engineering (General)
LCC:Biology (General)
LCC:Physics
LCC:Chemistry
مصطلحات موضوعية: knee joint distraction, osteophyte, osteoarthritis, high tibial osteotomy, TGFβ-1, joint-preserving, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
الوصف: Knee joint distraction (KJD) treatment has shown cartilage repair and clinical improvement in patients with osteoarthritis, as has high tibial osteotomy (HTO). Following KJD, TGFβ-1 and IL-6 were increased in synovial fluid (SF), factors related to cartilage regeneration, but also to osteophyte formation. As such, osteophyte formation after both joint-preserving treatments was studied. Radiographic osteophyte size was measured before, one year, and two years after treatment. Changes were compared with natural progression in patients from the CHECK cohort before undergoing total knee arthroplasty. An additional KJD cohort underwent SF aspiration, and one-year Altman osteophyte score changes were compared to SF-marker changes during treatment. After two years, both KJD (n = 58) and HTO (n = 38) patients showed an increase in osteophyte size (+6.2 mm2 and +7.0 mm2 resp.; both p < 0.004), with no significant differences between treatments (p = 0.592). Untreated CHECK patients (n = 44) did not show significant two-year changes (+2.1 mm2; p = 0.207) and showed significant differences with KJD and HTO (both p < 0.044). In SF aspiration patients (n = 17), there were significant differences in TGFβ-1 changes (p = 0.044), but not IL-6 (p = 0.898), between patients with a decrease, no change, or increase in osteophyte Altman score. Since KJD and HTO showed joint space widening and clinical improvement accompanied by osteophyte formation, increased osteophytosis after joint-preserving treatments may be a bystander effect of cartilage repair activity related to intra-articular factors like TGFβ-1 and raises questions regarding osteophyte formation as solely characteristic of the joint degenerative process.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2076-3417
العلاقة: https://www.mdpi.com/2076-3417/11/15/7156Test; https://doaj.org/toc/2076-3417Test
DOI: 10.3390/app11157156
الوصول الحر: https://doaj.org/article/cc4ebbe54d454d81993771f6657477adTest
رقم الانضمام: edsdoj.4ebbe54d454d81993771f6657477ad
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20763417
DOI:10.3390/app11157156