التفاصيل البيبلوغرافية
| العنوان: |
Lymphomagenesis-related gene expression in B cells from sustained virological responders with occult hepatitis C virus infection. |
| المؤلفون: |
Roque Cuéllar, M. C., García ‐ Lozano, J. R., Sánchez, B., Praena ‐ Fernández, J. M., Martínez Sierra, C., Núñez ‐ Roldán, A., Aguilar ‐ Reina, J. |
| المصدر: |
Journal of Viral Hepatitis; Aug2016, Vol. 23 Issue 8, p606-613, 8p |
| مصطلحات موضوعية: |
GENE expression, B cells, VIROLOGY, CYTIDINE deaminase, REVERSE transcriptase polymerase chain reaction, HEPATITIS C treatment |
| مستخلص: |
The expression of activation-induced cytidine deaminase, B-aggressive lymphoma, cyclin D1 and serine/threonine kinase 15 genes, among others, is increased in B cells from patients with chronic hepatitis C virus ( HCV) infection. It is unknown whether the level of expression of these genes in B cells is increased in patients with hepatitis C who have achieved a sustained virological response ( SVR) but who have persistent, detectable HCV RNA, so-called occult infection. Eighty-three patients who achieved and SVR, 27 with detectable HCV and 56 without detectable HCV RNA, 28 chronic hepatitis C patients and 32 healthy controls were studied. RNA was extracted from B cells, and gene expression levels were measured by RT- PCR. Patients with chronic HCV and those who achieved an SVR (with and without persistent low-level HCV RNA) showed a statistically significant higher expression compared to healthy controls, of activation-induced cytidine deaminase ( P = 0.004, P < 0.001 and P = 0.002, respectively), B-aggressive lymphoma ( P < 0.001, P = 0.001 and P = 0.006) and cyclin D1 ( P = 0.026, P = 0.001; P = 0.038). For activation-induced cytidine deaminase patients with an SVR and 'occult infection' had a statistically significantly higher expression level than patients with and SVR without 'occult infection' ( P = 0.014). The higher expression levels found for activation-induced cytidine deaminase, together with other genes indicates that these B lymphomagenesis-related genes are upregulated following HCV therapy and this is more marked when HCV can be detected in PBMCs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
