دورية أكاديمية
Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C.
| العنوان: | Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C. |
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| المؤلفون: | Trepo, Eric, Pradat, Pierre, Potthoff, Andrej, Momozawa, Yukihide, Quertinmont, Eric, Gustot, Thierry, Lemmers, Arnaud, Berthillon, Pascale, Amininejad, Leila, Chevallier, M., Schlué, Jerome, Kreipe, Hans, Devière, Jacques, Manns, Michael, Trepo, Christian, Sninsky, John, Wedemeyer, Heiner, Franchimont, Denis, Moreno, Christophe |
| المصدر: | Hepatology, 54 (1 |
| سنة النشر: | 2011 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Soins intensifs réanimation, Immunologie, Gastro-entérologie, Adult, Aged, Antiviral Agents -- therapeutic use, Belgium, Cross-Sectional Studies, Disease Progression, European Continental Ancestry Group -- genetics, Fatty Liver -- genetics -- pathology -- physiopathology, Female, France, Genetic Predisposition to Disease -- genetics, Germany, Hepatitis C, Chronic -- drug therapy -- genetics -- physiopathology, Humans, Interleukins -- therapeutic use, Lipase -- genetics, Liver Cirrhosis -- genetics -- pathology -- physiopathology, Longitudinal Studies, Male, Membrane Proteins -- genetics, Middle Aged, Polymorphism, Single Nucleotide -- genetics, Treatment Outcome |
| الوصف: | Only 20% of patients with chronic hepatitis C (CHC) will develop cirrhosis, and fibrosis progression remains highly unpredictable. A recent genome-wide association study identified a genetic variant in the patatin-like phospholipase-3 (PNPLA3) gene (rs738409 C>G) associated with steatosis that was further demonstrated to influence severity of fibrosis in nonalcoholic fatty liver disease. The aim of this study was to assess the impact of this polymorphism on histological liver damage and response to antiviral therapy in CHC. We recruited 537 Caucasian CHC patients from three European centers (Brussels, Belgium [n = 229]; Hannover, Germany [n = 171]; Lyon, France [n = 137]); these patients were centrally genotyped for the PNPLA3 (rs738409 C>G) polymorphism. We studied the influence of rs738409 and other variants in the PNPLA3 region on steatosis and fibrosis assessed both in a cross-sectional and longitudinal manner. Seven other variants previously associated with fibrosis progression were included. Finally, we explored the impact of rs738409 on response to standard antiviral therapy using the interferon lambda 3 (IL28B) [rs12979860 C>T] variant both as a comparator and as a positive control. After adjustment for age, sex, body mass index, alcohol consumption, and diabetes, rs738409 mutant G allele homozygote carriers remained at higher risk for steatosis (odds ratio [OR] 2.55, 95% confidence interval [CI] 1.08-6.03, P = 0.034), fibrosis (OR 3.13, 95% CI 1.50-6.51, P = 0.002), and fibrosis progression (OR 2.64, 95% CI 1.22-5.67, P = 0.013). Conversely, rs738409 was not independently associated with treatment failure (OR 1.07, 95% CI 0.46-2.49, P = 0.875) and did not influence clinical or biological variables. CONCLUSION: The PNPLA3 (rs738409 C>G) polymorphism favors steatosis and fibrosis progression in CHC. This polymorphism may represent a valuable genetic predictor and a potential therapeutic target in CHC liver damage. ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; FLWIN ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| ردمك: | 978-7-995955-40-9 7-995955-40-5 |
| العلاقة: | uri/info:doi/10.1002/hep.24350; uri/info:pmid/21488075; uri/info:scp/79959554057; https://dipot.ulb.ac.be/dspace/bitstream/2013/116839/3/116839.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/116839Test |
| الإتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/116839Test https://dipot.ulb.ac.be/dspace/bitstream/2013/116839/3/116839.pdfTest |
| رقم الانضمام: | edsbas.141C152C |
| قاعدة البيانات: | BASE |
| ردمك: | 9787995955409 7995955405 |
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