التفاصيل البيبلوغرافية
| العنوان: |
Severe hypocalcemia at admission is associated with increased transfusion requirements: A retrospective study in a level 1 trauma center. |
| المؤلفون: |
Liaud-Laval, Grégoire1 (AUTHOR), Libert, Nicolas1,2 (AUTHOR), Pissot, Matthieu1 (AUTHOR), Chrisment, Anne1 (AUTHOR), Ponsin, Pauline1 (AUTHOR), Boutonnet, Mathieu1,2 (AUTHOR), De Rudnicki, Stéphane1 (AUTHOR), Pasquier, Pierre1,2,3 (AUTHOR), Martinez, Thibault1 (AUTHOR) thibault.martinez@hotmail.fr |
| المصدر: |
Injury. Jan2024, Vol. 55 Issue 1, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*TRAUMA centers, *HYPOCALCEMIA, *INTENSIVE care units, *BLOOD grouping & crossmatching, *BLOOD products, *BLOOD transfusion reaction |
| مستخلص: |
• Hypocalcemia on admission is very common in patients with hemorrhagic trauma who died immediately or who were admitted to an intensive care unit. • In these patients, severe ionized hypocalcemia on admission is associated with higher transfusion requirements for all blood product type. • Severe hypocalcemia corrects within the first 12 h, despite transfusion, probably due to calcium substitution and clinical improvement. In recent years, hypocalcemia has been added to the "lethal triad" of the trauma patient, thus constituting the "lethal diamond". Nevertheless, its proper role remains debated. The aim of this study is to evaluate the association between severe hypocalcemia at admission and 24 h- transfusion requirements in severe trauma patients in a level 1 trauma center. In a monocentric retrospective observational study from January 2015 to May 2021, 137 traumatized adult patients transfused within 24 h after hospital admission was included in the study. The threshold for severe hypo ionized calcemia was ≤ 0.9 mmol/L. 137 patients were included in the study, 23 presented with severe hypo-iCa at admission, 111 moderate hypo-iCa (0.9–1.2 mmol/L) and 3 normal iCa (≥ 1.2 mmol/L). Patients with severe hypo-iCa at admission had higher severity scores (SAPSII 58 IQR [51–70] vs. 45 IQR [32–56]; p = 0.001 and ISS 34 IQR [26–39] vs. 26 IQR [17–34]; p = 0.003). 24 h-transfusion requirements were greater for patients with severe hypo-iCa, regardless of the type of blood products transfused. There was a significant negative correlation between admission iCa and 24 h-transfusion (r = −0.45, p < 0.001). The difference in mortality was not significant between the two groups (24 h mortality: 17 % (4/23) for severe hypo-iCa vs. 8 % (9/114) for non-severe hypo-iCa; p = 0.3). This study highlights the high prevalence of severe hypocalcemia in trauma patients and its association with increased 24 h- transfusion requirements. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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