التفاصيل البيبلوغرافية
| العنوان: |
Point-of-Care Versus Central Laboratory Measurements of Hemoglobin, Hematocrit, Glucose, Bicarbonate and Electrolytes: A Prospective Observational Study in Critically Ill Patients. |
| المؤلفون: |
Allardet-Servent, Jérôme, Lebsir, Melissa, Dubroca, Christian, Fabrigoule, Martine, Jordana, Sylvie, Signouret, Thomas, Castanier, Matthias, Thomas, Guillemette, Soundaravelou, Rettinavelou, Lepidi, Anne, Delapierre, Laurence, Penaranda, Guillaume, Halfon, Philippe, Seghboyan, Jean-Marie |
| المصدر: |
PLoS ONE; 1/10/2017, Vol. 12 Issue 1, p1-16, 16p |
| مصطلحات موضوعية: |
POINT-of-care testing, HEMOGLOBINS, CRITICALLY ill, BLOOD sugar measurement, ELECTROLYTE analysis, HEMATOCRIT, BICARBONATE ions |
| مستخلص: |
Introduction: Rapid detection of abnormal biological values using point-of-care (POC) testing allows clinicians to promptly initiate therapy; however, there are concerns regarding the reliability of POC measurements. We investigated the agreement between the latest generation blood gas analyzer and central laboratory measurements of electrolytes, bicarbonate, hemoglobin, hematocrit, and glucose. Methods: 314 paired samples were collected prospectively from 51 critically ill patients. All samples were drawn simultaneously in the morning from an arterial line. BD Vacutainer tubes were analyzed in the central laboratory using Beckman Coulter analyzers (AU 5800 and DxH 800). BD Preset 3 ml heparinized-syringes were analyzed immediately in the ICU using the POC Siemens RAPIDPoint 500 blood gas system. We used CLIA proficiency testing criteria to define acceptable analytical performance and interchangeability. Results: Biases, limits of agreement (±1.96 SD) and coefficients of correlation were respectively: 1.3 (-2.2 to 4.8 mmol/L, r = 0.936) for sodium; 0.2 (-0.2 to 0.6 mmol/L, r = 0.944) for potassium; -0.9 (-3.7 to 2 mmol/L, r = 0.967) for chloride; 0.8 (-1.9 to 3.4 mmol/L, r = 0.968) for bicarbonate; -11 (-30 to 9 mg/dL, r = 0.972) for glucose; -0.8 (-1.4 to -0.2 g/dL, r = 0.985) for hemoglobin; and -1.1 (-2.9 to 0.7%, r = 0.981) for hematocrit. All differences were below CLIA cut-off values, except for hemoglobin. Conclusions: Compared to central Laboratory analyzers, the POC Siemens RAPIDPoint 500 blood gas system satisfied the CLIA criteria of interchangeability for all tested parameters, except for hemoglobin. These results are warranted for our own procedures and devices. Bearing these restrictions, we recommend clinicians to initiate an appropriate therapy based on POC testing without awaiting a control measurement. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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