التفاصيل البيبلوغرافية
| العنوان: |
N-terminal pro-brain natriuretic peptide predicts hospitalization for ischemic stroke in Japanese hemodialysis patients. |
| المؤلفون: |
Yamaoka, Mai, Yoshida, Mahoko, Nakashima, Ayumu, Doi, Shigehiro, Naito, Takayuki, Masaki, Takao |
| المصدر: |
Clinical & Experimental Nephrology; Nov2022, Vol. 26 Issue 11, p1111-1118, 8p |
| مصطلحات موضوعية: |
BRAIN natriuretic factor, ISCHEMIC stroke, PROPORTIONAL hazards models, HEMODIALYSIS patients, HEMORRHAGIC stroke, HOSPITAL care |
| مستخلص: |
Background: The association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and stroke in Japanese hemodialysis (HD) outpatients is unclear. Therefore, in this study, we investigate whether high NT-proBNP levels are associated with future stroke events in this population. Methods: This was a multicenter prospective observational study with post hoc analysis. Baseline NT-proBNP levels were measured at the first HD session of the week and classified into tertiles (first tertile: < 2255 pg/mL; second tertile: ≥ 2255 and < 5657 pg/mL; third tertile: ≥ 5657 pg/mL). Overall hospitalization-free survival rates were compared using the Kaplan–Meier method. The association between NT-proBNP level and hospitalization for stroke was assessed using the multivariate Cox proportional hazards models. Results: During a 5-year follow-up of 1,229 patients, 103 (8.4%) were hospitalized and 23 (1.9%) died from stroke. The hospitalization-free survival rate for ischemic stroke was lowest in the third tertile (P < 0.01). The crude hazard ratio (HR) of hospitalization was higher in the third tertile compared with the first tertile for both ischemic stroke (HR: 3.92; 95% confidence interval [CI] 2.08–7.37; P < 0.01) and hemorrhagic stroke (HR: 3.75; 95% CI 1.35–10.43; P = 0.01). On multivariate Cox hazard analysis, the adjusted HRs for ischemic stroke were higher in the third tertile. The hospitalization-free survival rates for hemorrhagic stroke and the adjusted HRs did not differ significantly. Conclusions: Elevated NT-proBNP level was associated with hospitalization for ischemic stroke, suggesting that NT-proBNP level is a valid biomarker for predicting hospitalization for ischemic stroke in HD outpatients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
