المؤلفون: Arif B. Ekici, Helmut Blum, Sebastian Kämpf, Sebastian Vosberg, Cornelia Schlee, Martin Schrappe, Michael A. Rieger, Philipp A. Greif, Nicola Gökbuget, Stefan Krebs, Konstandina Isaakidis, Monika Brüggemann, Lorenz Bastian, Sonja Hänzelmann, Jutta Ortiz Tanchez, Michael P Schroeder, Stefan Schwartz, Thomas Burmeister, Martin Neumann, Alva Rani James, Martin A. Horstmann, Jochen Hecht, Veronika Schulze, Juan Lázaro-Navarro, Dimitrios L. Wagner, Claudia D. Baldus, Cornelia Eckert

المصدر: Leukemia. 33(8)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Aneuploidy, Loss of Heterozygosity, Biology, Compound heterozygosity, Loss of heterozygosity, 03 medical and health sciences, 0302 clinical medicine, CDKN2A, hemic and lymphatic diseases, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, medicine, Humans, B cell, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p15, PAX5 Transcription Factor, Chromosome, Hematology, DNA Methylation, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, DNA methylation, Mutation, Cancer research, PAX5, Chromosomes, Human, Pair 9, Energy Metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a03de9c1db73df7be22949b25957185Test
https://pubmed.ncbi.nlm.nih.gov/30842609Test

المؤلفون: Lydie, Debaize, Hélène, Jakobczyk, Stéphane, Avner, Jérémie, Gaudichon, Anne-Gaëlle, Rio, Aurélien A, Sérandour, Lena, Dorsheimer, Frédéric, Chalmel, Jason S, Carroll, Martin, Zörnig, Michael A, Rieger, Olivier, Delalande, Gilles, Salbert, Marie-Dominique, Galibert, Virginie, Gandemer, Marie-Bérengère, Troadec

المساهمون: Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Integrative Oncogenomics of Multiple Myeloma Pathogenesis and Progression (CRCINA-ÉQUIPE 11), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), École Centrale de Nantes (ECN), Department of Medicine, Hematology/Oncology [Frankfurt, Germany], Goethe-University Frankfurt am Main, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Cancer Research UK [Cambridge, UK] (Cambridge Institute), University of Cambridge [UK] (CAM), Georg-Speyer-Haus [Frankfurt, Germany], Institute for Tumor Biology and Experimental Therapy [Frankfurt, Germany], Génétique Somatique des Cancers [CHU Rennes], CHU Pontchaillou [Rennes], Département d'oncohématologie pédiatrique [CHU Rennes], Ligue Régionale contre le cancer [comité 22,35,56,79,41 to M.B.T., L.D., V.G.], SFR Biosit UMS CNRS 3480-INSERM 018 (to M.B.T.), Région Bretagne (to L.D., M.B.T.), The Société Française d’Hématologie (to L.D.), Rennes Métropole (to M.B.T.), French Research Ministry (to H.J.), FHUCAMIN (to J.G., V.G.), the société française de lutte contre les cancers et les leucémies de l’enfant et de l’adolescent and the Fédération Enfants et Santé (to M.B.T.), a private donator Mrs M-Dominique Blanc-Bert (to M.B.T.), Cancéropole Grand Ouest (to L.D.), The Société Française de Biochimie et Biologie Moléculaire (to H.J.), CNRS, Université de Rennes 1 and the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme [FP7/2007-2013] under REA grant agreement [291851 to M.B.T.]. Funding for open access charge: People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme., European Project: 291851,EC:FP7:PEOPLE,FP7-PEOPLE-2011-CIG,ALLRUN(2012), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Carroll, Jason [0000-0003-3643-0080], Apollo - University of Cambridge Repository, Bernardo, Elizabeth, Modeling TEL/AML1 childhood lymphoblastic leukemia in zebrafish - ALLRUN - - EC:FP7:PEOPLE2012-02-01 - 2016-01-31 - 291851 - VALID

المصدر: Nucleic Acids Research
Nucleic Acids Research, 2018, 46 (21), pp.11214-11228. ⟨10.1093/nar/gky756⟩
Nucleic Acids Research, Oxford University Press, 2018, 46 (21), pp.11214-11228. ⟨10.1093/nar/gky756⟩

مصطلحات موضوعية: Transcription, Genetic, Primary Cell Culture, Antineoplastic Agents, Bone Marrow Cells, [SDV.CAN]Life Sciences [q-bio]/Cancer, Mice, [SDV.CAN] Life Sciences [q-bio]/Cancer, Mice, Inbred NOD, Cell Line, Tumor, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, hemic and lymphatic diseases, Animals, Humans, ddc:610, Cell Proliferation, Binding Sites, Base Sequence, Gene Expression Regulation, Leukemic, Precursor Cells, B-Lymphoid, Gene regulation, Chromatin and Epigenetics, RNA-Binding Proteins, Xenograft Model Antitumor Assays, Chromatin, DNA-Binding Proteins, Proto-Oncogene Proteins c-kit, Enhancer Elements, Genetic, HEK293 Cells, Core Binding Factor Alpha 2 Subunit, embryonic structures, Imatinib Mesylate, Protein Binding, Signal Transduction

وصف الملف: application/pdf; application/octet-stream

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::15b02565ce5f3ff9c01d0bedfa9292cbTest
https://www.hal.inserm.fr/inserm-01885128Test

المؤلفون: Hartmut Geiger, David A. Williams, Michael D. Milsom, Paul Kaschutnig, Katja Muedder, Irem Bayindir, Anja Geiselhart, Anna Jauch, Steven W. Lane, Andreas Trumpp, Sina Huntscha, Tobias P. Dick, Dagmar Walter, Peter Schmezer, Michael A. Rieger, Timm Schroeder, Mirko C. Sobotta, David Brocks, Tim Holland-Letz, Marieke A.G. Essers, Amelie Lier, Corinna Klein, Bettina Moehrle, Frederic B. Thalheimer

المصدر: Nature. 520:549-552

مصطلحات موضوعية: Genome instability, Programmed cell death, DNA damage, Biology, Mice, Bone Marrow, Stress, Physiological, hemic and lymphatic diseases, medicine, Animals, Cell Proliferation, Multidisciplinary, Cell Death, Cell Cycle, Bone marrow failure, DNA Repair Pathway, Anatomy, Cell cycle, Hematopoietic Stem Cells, medicine.disease, Haematopoiesis, Fanconi Anemia, Cancer research, Stem cell, Reactive Oxygen Species, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540fa505842b8476b02bf4f5e1b80846Test
https://doi.org/10.1038/nature14131Test

المؤلفون: Hubert Serve, Oliver G. Ottmann, B Wojcik, S Bothur, Jhf Falkenburg, F Lang, Michael A. Rieger, Timm Schroeder, C Knecht

المصدر: Leukemia, 31 (3)
Leukemia

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.medical_specialty, CD34, Antigens, CD34, Biology, 03 medical and health sciences, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Internal medicine, hemic and lymphatic diseases, medicine, Humans, ddc:610, Letter to the Editor, B cell, Hematology, hemic and immune systems, medicine.disease, ADP-ribosyl Cyclase 1, Lymphoma, Haematopoiesis, Leukemia, 030104 developmental biology, medicine.anatomical_structure, Oncology, Apoptosis, Immunology, Neoplastic Stem Cells, Stem cell, Biomarkers

وصف الملف: application/application/pdf; application/octet-stream; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61038fe3269f03b720cecbb7eba707e9Test

المؤلفون: Thomas Oellerich, Sebastian Mohr, Tobias Berg, Christian Brandts, Jasmin Corso, Jürgen Wienands, Michael Engelke, Henning Urlaub, Marika Nimz, Mark F. Oellerich, Michael A. Rieger, Jing Zhang, Hanibal Bohnenberger, Silvia Münch, He-Hsuan Hsiao, Gesine Bug, Hubert Serve

المصدر: Blood

مصطلحات موضوعية: STAT3 Transcription Factor, Myeloid, Cell Survival, Molecular Sequence Data, Immunology, Integrin, Syk, Models, Biological, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, STAT5 Transcription Factor, Tumor Cells, Cultured, medicine, Humans, Syk Kinase, Amino Acid Sequence, STAT3, Protein Kinase Inhibitors, STAT5, Cell Proliferation, 030304 developmental biology, 0303 health sciences, biology, Cell growth, Chemistry, Intracellular Signaling Peptides and Proteins, Cell Biology, Hematology, Protein-Tyrosine Kinases, medicine.disease, Leukemia, Myeloid, Acute, STAT Transcription Factors, Leukemia, medicine.anatomical_structure, CD18 Antigens, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Signal transduction, Signal Transduction

وصف الملف: application/pdf; application/vnd.ms-excel

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6c41ed5fe324772ff5ac8c2a29b643Test
https://doi.org/10.1182/blood-2012-09-457887Test

المؤلفون: Florian Kuchenbauer, Henning Urlaub, Hanibal Bohnenberger, R K Humphries, Carsten Müller-Tidow, Tobias Berg, Arefeh Rouhi, Federico Comoglio, Jasmin Corso, Lars Palmqvist, Thomas Oellerich, Anjali Cremer, Anthony R. Green, Kimberly Stegmaier, Philipp Ströbel, Halvard Bonig, Hubert Serve, Astrid Wachter, Frank Schnütgen, Joachim Beck, Ekkehard Schütz, Timm Schroeder, Sebastian Mohr, Tim Beissbarth, Stefanie Göllner, Michael A. Rieger, Nadine Haetscher, Carmen Doebele, Gabriela Alexe

المساهمون: Green, Tony [0000-0002-9795-0218], Apollo - University of Cambridge Repository

المصدر: Cancer Cell
Cancer Cell, 31 (4)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Myeloid, Hox genes, Leukemia, microRNA, PU.1, Signal transduction, Syk, Context (language use), Kaplan-Meier Estimate, Biology, Article, 03 medical and health sciences, Downregulation and upregulation, hemic and lymphatic diseases, medicine, Animals, Humans, Syk Kinase, ddc:610, Myeloid Ecotropic Viral Integration Site 1 Protein, Transcription factor, Homeodomain Proteins, Gene Expression Regulation, Leukemic, Integrin beta3, leukemia, Myeloid leukemia, Hoxa9, Meis1, medicine.disease, 3. Good health, Neoplasm Proteins, Mice, Inbred C57BL, Leukemia, Myeloid, Acute, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Oncology, Cancer research, signal transduction

وصف الملف: application/pdf; application/octet-stream; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet; application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efacd144f9b8d6f3595037a9fef22cc8Test
https://pubmed.ncbi.nlm.nih.gov/28399410Test

المؤلفون: Jürgen Wienands, Hanibal Bohnenberger, Jennifer Hüllein, Federico Comoglio, Sebastian Mohr, Philipp Ströbel, Carmen Doebele, Henning Urlaub, Michael Engelke, Michael A. Rieger, Thorsten Zenz, Jasmin Corso, Thomas Oellerich, Kuan-Ting Pan, Roland Walter, Christof Lenz, Mikolaj Slabicki, Hubert Serve

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: 0301 basic medicine, Cell Survival, B-cell receptor, Receptors, Antigen, B-Cell, Biology, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Cell Line, Tumor, medicine, Humans, Phosphorylation, B-Lymphocytes, Multidisciplinary, Effector, Kinase, breakpoint cluster region, Phosphoproteomics, Biological Sciences, medicine.disease, Burkitt Lymphoma, 3. Good health, Lymphoma, Cell biology, 030104 developmental biology, 030220 oncology & carcinogenesis, Burkitt's lymphoma, Protein Processing, Post-Translational, Signal Transduction

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet; application/vnd.openxmlformats-officedocument.wordprocessingml.document

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ead9b1b35bff7b8129046792a448577Test
https://europepmc.org/articles/PMC4878517Test/

المؤلفون: Sebastian Newrzela, M Eißmann, I M Melzer, Manfred Schmidt, Anna Jauch, M. Hrabě de Angelis, G Michel, Nadine Haetscher, Manuel Grez, Michel Mittelbronn, Cynthia C. Bartholomae, Gerald Hoefler, Sara B. Mateus Fernández, C Zachskorn, B Schoell, Michael A. Rieger, Martin Zörnig, P Finkenwirth

المصدر: Oncogene
Oncogene; Vol 32
Oncogene 32, 2586–2591 (2013)

مصطلحات موضوعية: Cancer Research, Acute myeloblastic leukemia, Molecular Sequence Data, Mice, Transgenic, Biology, Lymphoma, T-Cell, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Inhibitor of apoptosis, medicine.disease_cause, Mice, 03 medical and health sciences, 0302 clinical medicine, Growth factor receptor, Cell Line, Tumor, hemic and lymphatic diseases, Genetics, medicine, Animals, Humans, Molecular Biology, Childhood Acute Lymphoblastic Leukemia, AVEN, apoptosis, T-ALL, acute lymphoblastic leukemia, p53, transgenic mice, Adaptor Proteins, Signal Transducing, 030304 developmental biology, 0303 health sciences, Gene knockdown, Thymocytes, Base Sequence, Gene Expression Regulation, Leukemic, Membrane Proteins, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Cell cycle, Genes, p53, medicine.disease, Xenograft Model Antitumor Assays, 3. Good health, Mice, Inbred C57BL, Apoptosis, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Cancer research, Apoptosis Regulatory Proteins, Carcinogenesis

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953ba53f874b2104fb2036b7b10bdb6cTest

المؤلفون: Christiane Pott, Peter Dreger, Bärbel Seyfarth, Norbert Schmitz, Michael Kneba, Anthony D. Ho, Manfred Hensel, Michael A. Rieger

المصدر: Haematologica. 92:42-49

مصطلحات موضوعية: Adult, Male, Oncology, medicine.medical_specialty, Cyclophosphamide, Prednisolone, medicine.medical_treatment, Lymphoma, Mantle-Cell, Transplantation, Autologous, Disease-Free Survival, Antibodies, Monoclonal, Murine-Derived, Autologous stem-cell transplantation, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Prospective Studies, Aged, Proportional Hazards Models, Chemotherapy, business.industry, Antibodies, Monoclonal, Hematology, Middle Aged, Total body irradiation, medicine.disease, Lymphoma, Regimen, Treatment Outcome, Doxorubicin, Vincristine, Immunology, Female, Rituximab, Mantle cell lymphoma, business, Stem Cell Transplantation, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d7b9369fbc98f177a870a137316853Test
https://doi.org/10.3324/haematol.10608Test

المؤلفون: Hubert Serve, Thomas Oellerich, Helge Hussong, Nicole Kohrs, Carol Stocking, Kira Behrens, Henning Urlaub, Stefanie Herkt, Julia Herglotz, Halvard Bonig, Bartosch Wojcik, Stephan Kolodziej, Jörn Lausen, Joachim Koch, Michael A. Rieger, Jasmin Corso, Ashok Kumar, Olga N. Kuvardina

المصدر: Blood

مصطلحات موضوعية: Hematopoiesis and Stem Cells, Cellular differentiation, Immunology, Kruppel-Like Transcription Factors, KLF1, Antigens, CD34, Biology, Biochemistry, Thrombopoiesis, chemistry.chemical_compound, hemic and lymphatic diseases, Proto-Oncogene Proteins, Basic Helix-Loop-Helix Transcription Factors, Humans, Erythropoiesis, Erythroid Precursor Cells, T-Cell Acute Lymphocytic Leukemia Protein 1, Megakaryocyte Progenitor Cells, Regulation of gene expression, GATA2, food and beverages, Cell Differentiation, Cell Biology, Hematology, RUNX1, chemistry, Gene Expression Regulation, FLI1, embryonic structures, Core Binding Factor Alpha 2 Subunit, Cancer research, K562 Cells, Megakaryocytes, TAL1

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b3e198ad52e2952b9ebd4d67d61b31Test
https://europepmc.org/articles/PMC4463808Test/