نتائج البحث - "Katja Seipel"

1

Rationale for a Combination Therapy with the STAT5 Inhibitor AC-4-130 and the MCL1 Inhibitor S63845 in the Treatment of FLT3-Mutated or TET2-Mutated Acute Myeloid Leukemia

المؤلفون: Ulrike Bacher, Laura Flückiger, Thomas Pabst, Carolyn Graber, Katja Seipel

المصدر: International Journal of Molecular Sciences, Vol 22, Iss 8092, p 8092 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 15
Seipel, Katja; Graber, Carolyn; Flückiger, Laura; Bacher, Vera; Pabst, Thomas (2021). Rationale for a Combination Therapy with the STAT5 Inhibitor AC-4-130 and the MCL1 Inhibitor S63845 in the Treatment of FLT3-Mutated or TET2-Mutated Acute Myeloid Leukemia. International journal of molecular sciences, 22(15) MDPI 10.3390/ijms22158092 <http://dx.doi.org/10.3390/ijms22158092Test>

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_compound, 0302 clinical medicine, fluids and secretions, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, STAT5 Transcription Factor, Medicine, MCL1, Midostaurin, Biology (General), Spectroscopy, Trametinib, Kinase, ten-eleven translocation-2 (TET2), Myeloid leukemia, hemic and immune systems, General Medicine, 3. Good health, Computer Science Applications, DNA-Binding Proteins, Leukemia, Myeloid, Acute, Chemistry, myeloid leukemia cell differentiation protein (MCL1), 030220 oncology & carcinogenesis, embryonic structures, FLT3 Inhibitor, Combination therapy, QH301-705.5, tumor suppressor p53 (TP53), 610 Medicine & health, Thiophenes, Article, Catalysis, Dioxygenases, Inorganic Chemistry, 03 medical and health sciences, signal transducer and activator of transcription 5 (STAT5), acute myeloid leukemia (AML), Cell Line, Tumor, Proto-Oncogene Proteins, Humans, hematological malignancies, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, FMS-like tyrosine kinase 3 (FLT3), business.industry, Venetoclax, Tumor Suppressor Proteins, Organic Chemistry, Pyrimidines, 030104 developmental biology, fms-Like Tyrosine Kinase 3, chemistry, Cancer research, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a86caaa2cbf92ffdc34d64b704e8471Test
https://www.mdpi.com/1422-0067/22/15/8092Test

2

BMI1-Inhibitor PTC596 in Combination with MCL1 Inhibitor S63845 or MEK Inhibitor Trametinib in the Treatment of Acute Leukemia

المؤلفون: Ulrike Bacher, Basil Kopp, Thomas Pabst, Katja Seipel

المصدر: Cancers, Vol 13, Iss 581, p 581 (2021)
Cancers
Volume 13
Issue 3
Seipel, Katja; Kopp, Basil; Bacher, Ulrike; Pabst, Thomas (2021). BMI1-Inhibitor PTC596 in Combination with MCL1 Inhibitor S63845 or MEK Inhibitor Trametinib in the Treatment of Acute Leukemia. Cancers, 13(3) MDPI AG 10.3390/cancers13030581 <http://dx.doi.org/10.3390/cancers13030581Test>

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, NPM1, CD34, 610 Medicine & health, BMI1 Inhibitor PTC596, myeloid cell leukemia 1 (MCL1), lcsh:RC254-282, Article, 03 medical and health sciences, meningioma 1 (MN1), 0302 clinical medicine, acute myeloid leukemia (AML), hemic and lymphatic diseases, Medicine, MCL1, neoplasms, Trametinib, Acute leukemia, business.industry, MEK inhibitor, Myeloid leukemia, myelodysplastic syndrome (MDS), lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1), 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, tumor suppressor protein 53 (TP53), Cancer research, business, hematopoietic progenitor cell antigen cluster of differentiation 34 (CD34)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ba1f36042ffd3cdb925c7e8e62782eTest
https://www.mdpi.com/2072-6694/13/3/581Test

3

(2R,3S)-Dihydroxybutanoic Acid Synthesis as a Novel Metabolic Function of Mutant Isocitrate Dehydrogenase 1 and 2 in Acute Myeloid Leukemia

المؤلفون: Jeffrey R. Idle, Diren Beyoğlu, Thomas Pabst, Ulrike Bacher, Katja Seipel

المصدر: Cancers
Volume 12
Issue 10
Cancers, Vol 12, Iss 2842, p 2842 (2020)
Idle, Jeffrey R; Seipel, Katja; Bacher, Ulrike; Pabst, Thomas; Beyoğlu, Diren (2020). (2R,3S)-Dihydroxybutanoic Acid Synthesis as a Novel Metabolic Function of Mutant Isocitrate Dehydrogenase 1 and 2 in Acute Myeloid Leukemia. Cancers, 12(10) MDPI AG 10.3390/cancers12102842 <http://dx.doi.org/10.3390/cancers12102842Test>

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, IDH1, Metabolite, Mutant, 610 Medicine & health, acute myeloid leukemia, medicine.disease_cause, IDH2, lcsh:RC254-282, Article, isocitrate dehydrogenase 2, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, isocitrate dehydrogenase 1, hemic and lymphatic diseases, medicine, (2R,3S)-dihydroxybutanoic acid, Threonine, (2R)-hydroxyglutaric acid, neoplasms, Mutation, Chemistry, Myeloid leukemia, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Molecular biology, metabolomics, oncometabolite, 030104 developmental biology, Isocitrate dehydrogenase, Oncology, 030220 oncology & carcinogenesis, biomarker

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe076355dce1805bc1443b2a8f4b884Test
http://europepmc.org/articles/PMC7600928Test

4

MDM2- and FLT3-inhibitors in the treatment of FLT3-ITD acute myeloid leukemia, specificity and efficacy of NVP-HDM201 and midostaurin

المؤلفون: Thomas Pabst, Miguel A.T. Marques, Beatrice U. Mueller, Katja Seipel, Corinne Sidler

المصدر: Haematologica

مصطلحات موضوعية: Acute Myeloid Leukemia, Male, 0301 basic medicine, NPM1, Myeloid, HL-60 Cells, Article, 03 medical and health sciences, chemistry.chemical_compound, fluids and secretions, 0302 clinical medicine, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Cytotoxic T cell, Midostaurin, Enzyme Inhibitors, biology, business.industry, Wild type, Myeloid leukemia, Proto-Oncogene Proteins c-mdm2, hemic and immune systems, Hematology, Staurosporine, medicine.disease, Leukemia, Myeloid, Acute, Leukemia, 030104 developmental biology, medicine.anatomical_structure, fms-Like Tyrosine Kinase 3, chemistry, 030220 oncology & carcinogenesis, embryonic structures, biology.protein, Cancer research, Mdm2, Female, business, Nucleophosmin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d87a3f46f05337d04f986dc39c79468Test
https://doi.org/10.3324/haematol.2018.191650Test

5

MN1, FOXP1 and hsa-miR-181a-5p as prognostic markers in acute myeloid leukemia patients treated with intensive induction chemotherapy and autologous stem cell transplantation

المؤلفون: Gertrud Wiedemann, Ulrike Bacher, Katja Seipel, Thomas Pabst, Christian Messerli

المصدر: Leukemia research. 89

مصطلحات موضوعية: Adult, Male, Cancer Research, Myeloid, CD34, Peripheral blood mononuclear cell, Models, Biological, Transplantation, Autologous, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Autologous stem-cell transplantation, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Medicine, Humans, 610 Medicine & health, Aged, Retrospective Studies, business.industry, Tumor Suppressor Proteins, Hematopoietic Stem Cell Transplantation, Induction chemotherapy, Myeloid leukemia, Forkhead Transcription Factors, Hematology, Induction Chemotherapy, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, Repressor Proteins, Haematopoiesis, Leukemia, Myeloid, Acute, MicroRNAs, medicine.anatomical_structure, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Mutation, Cancer research, Trans-Activators, Female, Stem cell, business, Nucleophosmin, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df4593d94f150a7e9189cf98b99f336Test
https://pubmed.ncbi.nlm.nih.gov/31927137Test

6

Consolidation with autologous stem cell transplantation in first remission is safe and effective in AML patients above 65 years

المؤلفون: Urban Novak, Yara Banz, Alexander D Heini, Martin D. Berger, Katja Seipel, Kurt Leibundgut, Behrouz Mansouri Taleghani, Gabriela M. Baerlocher, Thomas Pabst

المصدر: Leukemia Research. 53:28-34

مصطلحات موضوعية: Male, Oncology, Cancer Research, medicine.medical_specialty, Transplantation Conditioning, Allogeneic transplantation, Cyclophosphamide, medicine.medical_treatment, Hematopoietic stem cell transplantation, Transplantation, Autologous, 03 medical and health sciences, 0302 clinical medicine, Autologous stem-cell transplantation, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Autologous transplantation, 610 Medicine & health, Busulfan, neoplasms, Survival rate, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Remission Induction, Age Factors, Hematopoietic Stem Cell Transplantation, Hematology, humanities, Surgery, Survival Rate, Leukemia, Myeloid, Acute, Treatment Outcome, 030220 oncology & carcinogenesis, 570 Life sciences, biology, Female, business, 030215 immunology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53332fa4ce07a3bdc5671013846c1f63Test
https://doi.org/10.1016/j.leukres.2016.12.001Test

7

Rationale for a Combination Therapy Consisting of MCL1- and MEK-Inhibitors in Acute Myeloid Leukemia

المؤلفون: Katja Seipel, Thomas Pabst, Ulrike Bacher, Karin Schmitter

المصدر: Cancers, Vol 11, Iss 11, p 1779 (2019)
Cancers
Volume 11
Issue 11
Seipel, Katja; Schmitter, Karin; Bacher, Ulrike; Pabst Müller, Thomas Niklaus (2019). Rationale for a Combination Therapy Consisting of MCL1-and MEK-Inhibitors in Acute Myeloid Leukemia. Cancers, 11(11) MDPI AG 10.3390/cancers11111779 <http://dx.doi.org/10.3390/cancers11111779Test>

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Myeloid, myeloid leukemia cell differentiation protein (mcl1), acute myeloid leukemia (aml), 610 Medicine & health, lcsh:RC254-282, Article, mitogen-activated protein kinase kinase (MEK, MAP2K, MAPKK), 03 medical and health sciences, 0302 clinical medicine, mapkk), tumor suppressor p53 (tp53), hemic and lymphatic diseases, medicine, MCL1, hematological malignancies, fms like tyrosine kinase 3 (flt3), mitogen-activated protein kinase kinase (mek, Trametinib, biology, Oncogene, Cell growth, business.industry, Myeloid leukemia, ribosomal protein s6 (rps6), medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Leukemia, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cancer research, biology.protein, map2k, Mdm2, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5359519e27088bb7edffadf3692f33aTest

8

Life-Threatening Primary Varicella Zoster Virus Infection With Hemophagocytic Lymphohistiocytosis-Like Disease in GATA2 Haploinsufficiency Accompanied by Expansion of Double Negative T-Lymphocytes

المؤلفون: Seraina Prader, Matthias Felber, Benjamin Volkmer, Johannes Trück, Agnes Schwieger-Briel, Martin Theiler, Lisa Weibel, Sophie Hambleton, Katja Seipel, Stefano Vavassori, Jana Pachlopnik Schmid

المصدر: Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)

مصطلحات موضوعية: lcsh:Immunologic diseases. Allergy, 0301 basic medicine, Male, endocrine system, Herpesvirus 3, Human, GATA2 Deficiency, T-Lymphocytes, Population, Immunology, Pilot Projects, Case Report, Disease, medicine.disease_cause, Lymphohistiocytosis, Hemophagocytic, 03 medical and health sciences, hemic and lymphatic diseases, medicine, Immunology and Allergy, Humans, education, Child, Cytopenia, Hemophagocytic lymphohistiocytosis, education.field_of_study, varicella-zoster virus, TCRγδ T cells, business.industry, fungi, Varicella zoster virus, primary immumunodeficiencies, medicine.disease, musculoskeletal system, GATA2 Transcription Factor, 030104 developmental biology, hemophagocytic lymphohistiocytosis, Varicella Zoster Virus Infection, Primary immunodeficiency, Female, Differential diagnosis, lcsh:RC581-607, Haploinsufficiency, business, NK cell abnormalities, hormones, hormone substitutes, and hormone antagonists

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f91c897fdeb085570b3cd4dbdb21556Test
https://pubmed.ncbi.nlm.nih.gov/30564229Test

9

Autologous Transplantation for Older Adults with AML

المؤلفون: Beatrice U. Mueller, Ulrike Bacher, Katja Seipel, Thomas Pabst

المصدر: Mueller, Beatrice; Seipel, Katja; Bacher, Vera Ulrike; Pabst, Thomas (2018). Autologous Transplantation for Older Adults with AML. Cancers, 10(9), p. 340. MDPI AG 10.3390/cancers10090340 <http://dx.doi.org/10.3390/cancers10090340Test>
Cancers, Vol 10, Iss 9, p 340 (2018)
Cancers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633f3aeed21a59d2cf5d051031d517bfTest
https://boris.unibe.ch/123665/1/cancers-10-00340.pdfTest

10

Myelodysplastic syndromes and acute myeloid leukemias in the elderly

المؤلفون: Thomas Pabst, Beatrice U. Mueller, Katja Seipel

مصطلحات موضوعية: 0301 basic medicine, Acute promyelocytic leukemia, Oncology, medicine.medical_specialty, Gemtuzumab ozogamicin, Antibodies, Monoclonal, Humanized, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Internal Medicine, medicine, Humans, Midostaurin, 610 Medicine & health, Geriatric Assessment, Aged, Randomized Controlled Trials as Topic, business.industry, Myelodysplastic syndromes, Daunorubicin, Remission Induction, Myeloid leukemia, Induction chemotherapy, medicine.disease, Staurosporine, Gemtuzumab, Transplantation, Leukemia, Myeloid, Acute, 030104 developmental biology, Aminoglycosides, Hypomethylating agent, chemistry, 030220 oncology & carcinogenesis, Myelodysplastic Syndromes, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15384fd36f7fff676956c6465070b3c6Test

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