المؤلفون: Palit, Sander A.L., Vis, Daniel, Stelloo, Suzan, Lieftink, Cor, Prekovic, Stefan, Bekers, Elise, Hofland, Ingrid, Šuštić, Tonći, Wolters, Liesanne, Beijersbergen, Roderick, Bergman, Andries M., Győrffy, Balázs, Wessels, Lodewyk F.A., Zwart, Wilbert, van der Heijden, Michiel S.

المصدر: Palit , S A L , Vis , D , Stelloo , S , Lieftink , C , Prekovic , S , Bekers , E , Hofland , I , Šuštić , T , Wolters , L , Beijersbergen , R , Bergman , A M , Győrffy , B , Wessels , L F A , Zwart , W & van der Heijden , M S 2019 , ' TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth ' , eLife , vol. 8 , e47430 . https://doi.org/10.7554/eLife.47430Test

مصطلحات موضوعية: AR, CRISPR-Cas9 screen, Drug resistance, Enzalutamide, GR, Prostate cancer, TLE3, Androgen Receptor Antagonists/pharmacology, Humans, Male, Gene Expression Regulation, Neoplastic/drug effects, Prostate/metabolism, Hepatocyte Nuclear Factor 3-alpha/genetics, Phenylthiohydantoin/analogs & derivatives, CRISPR-Cas Systems/genetics, Receptors, Androgen/genetics, Neoplasm/genetics, HEK293 Cells, Cell Line, Tumor, Transcriptional Activation/drug effects, Prostatic Neoplasms/drug therapy, Glucocorticoid/genetics, Cell Proliferation/drug effects, Co-Repressor Proteins/genetics, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

العلاقة: https://research.tue.nl/en/publications/9e1e0d8b-0968-4afb-ad29-65c3fbed657fTest

الإتاحة: https://doi.org/10.7554/eLife.47430Test
https://research.tue.nl/en/publications/9e1e0d8b-0968-4afb-ad29-65c3fbed657fTest
http://www.scopus.com/inward/record.url?scp=85077548136&partnerID=8YFLogxKTest

المؤلفون: Palit, Sander A.L., Vis, Daniel, Stelloo, Suzan, Lieftink, Cor, Prekovic, Stefan, Bekers, Elise, Hofland, Ingrid, Šuštić, Tonći, Wolters, Liesanne, Beijersbergen, Roderick, Bergman, Andries M., Győrffy, Balázs, Wessels, Lodewyk F.A., Zwart, Wilbert, van der Heijden, Michiel S.

المصدر: Palit , S A L , Vis , D , Stelloo , S , Lieftink , C , Prekovic , S , Bekers , E , Hofland , I , Šuštić , T , Wolters , L , Beijersbergen , R , Bergman , A M , Győrffy , B , Wessels , L F A , Zwart , W & van der Heijden , M S 2019 , ' TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth ' , eLife , vol. 8 , e47430 . https://doi.org/10.7554/eLife.47430Test

مصطلحات موضوعية: AR, CRISPR-Cas9 screen, Drug resistance, Enzalutamide, GR, Prostate cancer, TLE3, Androgen Receptor Antagonists/pharmacology, Humans, Male, Gene Expression Regulation, Neoplastic/drug effects, Prostate/metabolism, Hepatocyte Nuclear Factor 3-alpha/genetics, Phenylthiohydantoin/analogs & derivatives, CRISPR-Cas Systems/genetics, Receptors, Androgen/genetics, Neoplasm/genetics, HEK293 Cells, Cell Line, Tumor, Transcriptional Activation/drug effects, Prostatic Neoplasms/drug therapy, Glucocorticoid/genetics, Cell Proliferation/drug effects, Co-Repressor Proteins/genetics, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

العلاقة: https://research.tue.nl/en/publications/9e1e0d8b-0968-4afb-ad29-65c3fbed657fTest

الإتاحة: https://doi.org/10.7554/eLife.47430Test
https://research.tue.nl/en/publications/9e1e0d8b-0968-4afb-ad29-65c3fbed657fTest
http://www.scopus.com/inward/record.url?scp=85077548136&partnerID=8YFLogxKTest

المؤلفون: Šuštić, Tonći, van Wageningen, Sake, Bosdriesz, Evert, Reid, Robert J D, Dittmar, John, Lieftink, Cor, Beijersbergen, Roderick L, Wessels, Lodewyk F A, Rothstein, Rodney, Bernards, René

المصدر: Šuštić , T , van Wageningen , S , Bosdriesz , E , Reid , R J D , Dittmar , J , Lieftink , C , Beijersbergen , R L , Wessels , L F A , Rothstein , R & Bernards , R 2018 , ' A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers ' , Genome Medicine , vol. 10 , no. 1 , 90 , pp. 90 . https://doi.org/10.1186/s13073-018-0600-zTest

مصطلحات موضوعية: Antineoplastic Agents/pharmacology, Benzimidazoles/pharmacology, Cell Line, Tumor, Colonic Neoplasms/drug therapy, Endoplasmic Reticulum Stress, Endoribonucleases/genetics, HEK293 Cells, Humans, MAP Kinase Kinase Kinases/antagonists & inhibitors, Protein Kinase Inhibitors/pharmacology, Protein-Serine-Threonine Kinases/genetics, Proto-Oncogene Proteins c-jun/genetics, Proto-Oncogene Proteins p21(ras)/genetics, Pyridones/pharmacology, Pyrimidinones/pharmacology, Unfolded Protein Response, Yeasts/genetics, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

العلاقة: https://research.vu.nl/en/publications/81f28fe1-8e98-46c2-b48a-ecb93db7aac0Test

الإتاحة: https://doi.org/10.1186/s13073-018-0600-zTest
https://research.vu.nl/en/publications/81f28fe1-8e98-46c2-b48a-ecb93db7aac0Test
https://hdl.handle.net/1871.1/81f28fe1-8e98-46c2-b48a-ecb93db7aac0Test
http://www.scopus.com/inward/record.url?scp=85057273107&partnerID=8YFLogxKTest
http://www.scopus.com/inward/citedby.url?scp=85057273107&partnerID=8YFLogxKTest

المؤلفون: Šuštić, Tonći, van Wageningen, Sake, Bosdriesz, Evert, Reid, Robert J D, Dittmar, John, Lieftink, Cor, Beijersbergen, Roderick L, Wessels, Lodewyk F A, Rothstein, Rodney, Bernards, René

المصدر: Šuštić , T , van Wageningen , S , Bosdriesz , E , Reid , R J D , Dittmar , J , Lieftink , C , Beijersbergen , R L , Wessels , L F A , Rothstein , R & Bernards , R 2018 , ' A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers ' , Genome Medicine , vol. 10 , no. 1 , 90 , pp. 90 . https://doi.org/10.1186/s13073-018-0600-zTest

مصطلحات موضوعية: Antineoplastic Agents/pharmacology, Benzimidazoles/pharmacology, Cell Line, Tumor, Colonic Neoplasms/drug therapy, Endoplasmic Reticulum Stress, Endoribonucleases/genetics, HEK293 Cells, Humans, MAP Kinase Kinase Kinases/antagonists & inhibitors, Protein Kinase Inhibitors/pharmacology, Protein-Serine-Threonine Kinases/genetics, Proto-Oncogene Proteins c-jun/genetics, Proto-Oncogene Proteins p21(ras)/genetics, Pyridones/pharmacology, Pyrimidinones/pharmacology, Unfolded Protein Response, Yeasts/genetics, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

العلاقة: https://research.vu.nl/en/publications/81f28fe1-8e98-46c2-b48a-ecb93db7aac0Test

الإتاحة: https://doi.org/10.1186/s13073-018-0600-zTest
https://research.vu.nl/en/publications/81f28fe1-8e98-46c2-b48a-ecb93db7aac0Test
https://hdl.handle.net/1871.1/81f28fe1-8e98-46c2-b48a-ecb93db7aac0Test
http://www.scopus.com/inward/record.url?scp=85057273107&partnerID=8YFLogxKTest
http://www.scopus.com/inward/citedby.url?scp=85057273107&partnerID=8YFLogxKTest