التفاصيل البيبلوغرافية
| العنوان: |
Greater intrinsic arterial wall stiffness and its unfavourable trajectory over time in type 2 diabetes. |
| المؤلفون: |
Aizawa, Kunihiko, Gates, Phillip E., Mawson, David M., Casanova, Francesco, Gooding, Kim M., Hope, Suzy V., Goncalves, Isabel, Nilsson, Jan, Kahn, Faisel, Colhoun, Helen M., Natali, Andrea, Palombo, Carlo, Shore, Angela C. |
| المصدر: |
Artery Research; 2023 Supplement, Vol. 29 Issue 1, pS9-S10, 2p |
| مصطلحات موضوعية: |
ARTERIAL diseases, TYPE 2 diabetes, CAROTID artery |
| مستخلص: |
Background: A greater central artery stiffness is observed in people with type 2 diabetes (T2DM). However, it is unclear about intrinsic arterial wall stiffness in these patients. We aimed to determine the utility of βo cross-sectionally and longitudinally in T2DM. Methods: We studied 753 adults with T2DM (DM+: 67.5 ± 8.3 years, 227F) and 436 adults without T2DM (DM-: 67.0 ± 9.2 years, 159F) cross-sectionally (Phase 1), and subsequently studied 310 adults in DM + (68.6 ± 7.6 years, 104F) and 210 adults in DM- (67.6 ± 8.5 years, 83F) over three years longitudinally (Phase 2). Carotid-femoral pulse wave velocity was measured, and its data were used to calculate βo as previously described. Results: In Phase 1, βo was significantly greater in DM+ than DM- after adjusting for age and sex [27.5 (26.6-28.3) vs 23.6 (22.4-24.8) au, p < 0.001]. Partial correlation analyses after adjusting for age and sex found that βo was significantly associated with HbA1c (r = 0.15 p < 0.001) and heart rate (r = 0.23 p < 0.001) in DM+. I Phase 2, percentage changes in βo were significantly greater in DM + than DM- [19.5 (14.9-24.0) vs 5.0 (- 0.6-10.6) %, p < 0.001] after adjusting for age, sex and baseline βo. Multivariable linear regression analyses revealed that the percentage changes in βo were independently associated with percentage changes in heart rate in DM + (overall R² = 0.19). Conclusion: βo was greater in DM + than DM-. Furthermore, βo changed over three years with ageing but it changed much more in DM + than DM-. These data suggest that intrinsic arterial wall stiffness may be a useful target for therapeutic intervention. [ABSTRACT FROM AUTHOR] |
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