المؤلفون: Scanziani, Margherita¹, Pozzi, Matteo¹ mateo.pozzi@gmail.com, Rovere, Antonio², Rezoagli, Emanuele^1,3, Avalli, Leonello^1,3, Foti, Giuseppe^1,3

المصدر: Perfusion. Mar2024, Vol. 39 Issue 2, p420-422. 3p.

مصطلحات موضوعية: *MITRAL valve diseases, *FEMORAL vein, *MEDICAL device removal, *HEART valve prosthesis implantation, *TRANSESOPHAGEAL echocardiography, *EXTRACORPOREAL membrane oxygenation, *SURGICAL complications, *MULTIPLE organ failure, *AORTIC stenosis, *HEMOSTASIS, *ARTERIOVENOUS fistula, *VENTRICULAR dysfunction, *INFECTIVE endocarditis, *SEVERITY of illness index, *RIGHT ventricular dysfunction, *CARDIAC output, *PULMONARY edema, *COMPRESSION therapy, *DOPPLER ultrasonography, *ANGIOGRAPHY, *AORTIC valve insufficiency, *CARDIOPULMONARY bypass, *ACUTE diseases, *HEART failure, *SEPTIC shock, *HEART diseases, *DISEASE complications

مستخلص: Introduction: Vascular complications are a major issue in V-A ECMO and can affect long term outcome. Among these, Artero-Venous (AV) fistulas may lead to right heart failure. Case History: A 73-years patient supported with V-A ECMO for post-cardiotomy biventricular failure developed right heart failure after V-A ECMO decannulation, requiring V-A ECMO recannulation. The presence of an AV femoral fistula was incidentally revealed during femoral vein cannulation, from which oxygenated blood was unexpectedly drawn. The angiographic assessment confirmed the presence of a fistula between superficial femoral artery and vein, at the site of the first venous ECMO cannulation. This was caused by the venous cannula that inadvertently passed across the artery and created an AV fistula that was opened by the venous cannula removal. The exclusion of the endovascular fistula allowed the right heart failure resolution. Conclusions: In the presence of right heart failure after recent vascular manipulation, AV fistula should be ruled out. [ABSTRACT FROM AUTHOR]

العنوان البديل: Chronic disease valve degenerative decompensated mitral in a rabbit. (English)

المؤلفون: Monge Utrilla, Óscar, Albamonte Rodríguez, Andreu, Mosteiro Díaz, Daniel

المصدر: Argos (1699-7875); Dec2023, Issue 254, p24-28, 3p

مصطلحات موضوعية: HEART diseases, RABBITS, POLYURIA, MITRAL valve diseases, TRICUSPID valve diseases

مستخلص: The article focuses on the rising incidence of cardiac diseases in rabbits, attributing the increase to factors such as extended lifespan, enhanced knowledge of rabbit diseases, and improved diagnostic methods. It presents a specific case of a senior spayed dwarf rabbit with ocular opacity and polyuria. It is reported that the diagnosis involves a chronic degenerative mitral valve disease and chronic tricuspid valve degeneration.

العنوان البديل: Dispersão da onda P em cães obesos apresentando ou não doença valvar mitral.

المؤلفون: Dittrich, Gustavo¹, Van Der Broocke Campos, Gabriela Marin¹, Gonçalves Sousa, Marlos¹ marlos98@ufpr.br, Tostes Oliveira, Simone¹

المصدر: Ciência Rural. 2018, Vol. 48 Issue 10, p1-8. 8p.

مصطلحات موضوعية: *OBESITY in animals, *MITRAL valve diseases, *DIAGNOSIS of dog diseases, *ELECTROCARDIOGRAPHY, *ARRHYTHMIA diagnosis, *ATRIAL fibrillation, *HEART diseases

الملخص (بالإنجليزية): Pwave dispersion (Pd) is an electrocardiographic index defined as the difference between the minimum and maximum Pwave duration in multiple leads. The augmentation of Pd reflects the discontinuous and inhomogeneous atrial depolarization resulting from cardiac and non-cardiac conditions. In humans, an increased Pd is associated with the development of cardiac arrhythmias, particularly atrial fibrillation. To investigate Pd in obese dogs, we enrolled 76 dogs, which were classified in four distinct categories according to body condition and the existance of valve insufficiency: obese dogs (O), dogs with both obesity and cardiac disease (O+CD), lean dogs with cardiac disease (CD) and healthy controls (H). To be included in the study, all dogs underwent an electrocardiographic and echocardiographic assessment. We reported significantly higher Pd in the animals included in categories O, O+CD and CD (18.0±7.6ms, 16.1±4.4ms, 12.1±4.3ms, respectively) as compared to the healthy subjects (7.3±2.2ms). Also, significant correlations between Pd and both the body mass index and body fat percentage were documented for the obese dogs. However, no association between Pd and LA/Ao could be identified in patients belonging to the O, O+CD and H categories. Thus, we have demonstrated that obese dogs, regardless of their valvular competency status, present high Pd values, suggesting an impaired propagation of atrial electrical impulse. [ABSTRACT FROM AUTHOR]

Abstract (Portuguese): A dispersão da onda P (Pd) é um índice eletrocardiográfico definido como a diferença entre as durações máxima e mínima da onda P em múltiplas derivações. O aumento da Pd reflete a despolarização discontínua e não homogênea resultante de condições cardíacas e não cardíacas. Em seres humanos, uma Pdaumentada está associada com o desenvolvimento de arritmias cardíacas, particularmente fibrilação atrial. Com o intuito de investigar a Pd em cães obesos, foram selecionados 76 cães, os quais foram classificados em quatro categorias distintas, de acordo com sua condição corporal e a existência de insuficiência valvar: cães obesos (O), cães com obesidade e doença cardíaca (O+CD), cães magros com doença cardíaca (CD) e cães saudáveis usados como controle (H). Uma vez selecionados para o estudo, todos os cães foram submetidos às avaliações eletrocardiográfica e ecocardiográfica. Os resultados mostraram maior Pd nos animais pertencentes aos grupos O, O+CD e CD (18.0±7.6ms, 16,1±4,4ms, 12,1±4,3ms, respectivamente) quando comparados aos cães saudáveis (7.3±2.2ms). Além disso, foram verificadas correlações significativas entre Pde tanto o índice de massa corporal quanto o percentual de gordura corporal nos cães obesos. Entretanto, não se identificou associação entre Pd e a relação AE/Ao nos pacientes das categorias O, O+CD e H. Dessa forma, foi possível demonstrar que cães obesos, independentemente do estado de competência valvar, apresentam Pd elevada, fato que sugere comprometimento da propagação do impulso elétrico atrial. [ABSTRACT FROM AUTHOR]

المؤلفون: Meurs, K.M.¹ kate_meurs@ncsu.edu, Friedenberg, S.G.², Williams, B.¹, Keene, B.W.¹, Atkins, C.E.¹, Adin, D.¹, Aona, B.¹, DeFrancesco, T.¹, Tou, S.¹, Mackay, T.³

المصدر: Veterinary Journal. Feb2018, Vol. 232, p16-19. 4p.

مصطلحات موضوعية: *MITRAL valve diseases, *HEART diseases, *DOG breeds

مستخلص: Myxomatous mitral valve disease (MMVD) is the most common heart disease in the dog. It is believed to be heritable in Cavalier King Charles spaniels (CKCS) and Dachshunds. Myxomatous mitral valve disease is a familial disease in human beings as well and genetic mutations have been associated with its development. We hypothesized that a genetic mutation associated with the development of the human form of MMVD was associated with the development of canine MMVD. DNA was isolated from blood samples from 10 CKCS and 10 Dachshunds diagnosed with MMVD, and whole genome sequences from each animal were obtained. Variant calling from whole genome sequencing data was performed using a standardized bioinformatics pipeline for all samples. After filtering, the canine genes orthologous to the human genes known to be associated with MMVD were identified and variants were assessed for likely pathogenic implications. No variant was found in any of the genes evaluated that was present in least eight of 10 affected CKCS or Dachshunds. Although mitral valve disease in the CKCS and Dachshund is a familial disease, we did not identify genetic cause in the genes responsible for the human disease in the dogs studied here. [ABSTRACT FROM AUTHOR]

المؤلفون: POOR, BRITTANY

المصدر: Lakota Times; 3/13/2024, Vol. 20 Issue 27, pA1-A3, 2p

مصطلحات موضوعية: HEART diseases, MITRAL valve diseases, DEGLUTITION disorders in infants, INFANT diseases, CHILDREN'S hospitals

مستخلص: The article features Rylea Poor Bear, the daughter of Justin and Christine Poor Bear who was diagnosed with hypoplastic mitral valve, multiple hemivertebrae, and oral phase dysphagia. Topics discussed include her condition three days after her birth, her first open heart surgery at six days of age, and her life since arriving at the Stead Family Children's Hospital in Iowa City, Iowa.

المؤلفون: Monsefi, Nadejda¹ nadi037@aol.com, Zierer, Andreas¹, Khalil, Mahmud^1,2, Ay, Mahmut¹, Beiras-Fernandez, Andres¹, Moritz, Anton¹, Stock, Ulrich Alfred^1,2

المصدر: Texas Heart Institute Journal. Dec2014, Vol. 41 Issue 6, p609-612. 4p. 1 Color Photograph, 1 Chart.

مصطلحات موضوعية: *MITRAL valve surgery, *MITRAL valve diseases, *CARDIAC surgery, *HEART diseases, *THERAPEUTICS, *TRANSPLANTATION of organs, tissues, etc.

مستخلص: The MitraClip percutaneous mitral valve repair system, developed as an option for percutaneous mitral repair, was clinically introduced in 2007. From 2010 through 2012, 6 of our patients underwent mitral valve surgery after MitraClip failure. Their mean age was 75 ± 7.7 years (range, 62-87 yr). Three had undergone cardiac surgery previously. In 5 of the 6 patients, mitral regurgitation recurred after initially successful MitraClip deployment and was the indication for surgery. The mean interval between MitraClip implantation and surgery was 106 ± 86 days (range, 0-238 d). Mitral valve repair was feasible in 3 patients; the others underwent valve replacement. All the patients underwent additional cardiac procedures, because the MitraClip worsened existing conditions. Echocardiograms revealed sufficient valvular repairs. Two patients died during hospitalization, one of cerebral infarction and the other of bowel ischemia. Mitral valve repair after failed MitraClip therapy can be complex and a surgical challenge. Careful consideration should be given to appropriate patient selection for MitraClip therapy, because the MitraClip can cause existing pathologic valvular conditions to deteriorate substantially. The interval between MitraClip failure and corrective surgery should be as short as possible. The primary indication is an issue of ongoing discussion. [ABSTRACT FROM AUTHOR]

المؤلفون: Moorhead, K.T.¹, Paeme, S.¹ sabine.paeme@ulg.ac.be, Chase, J.G.², Kolh, P.¹, Pierard, L.¹, Hann, C.E.³, Dauby, P.C.¹, Desaive, T.¹

المصدر: Computer Methods & Programs in Biomedicine. Feb2013, Vol. 109 Issue 2, p190-196. 7p.

مصطلحات موضوعية: *MITRAL valve diseases, *HEART beat, *THERAPEUTICS, *HEART diseases, *STENOSIS, *HYSTERESIS, *ROTATIONAL motion (Rigid dynamics), *TORQUE

مستخلص: Abstract: Located between the left atrium and the left ventricle, the mitral valve controls flow between these two cardiac chambers. Mitral valve dysfunction is a major cause of cardiac dysfunction and its dynamics are little known. A simple non-linear rotational spring model is developed and implemented to capture the dynamics of the mitral valve. A measured pressure difference curve was used as the input into the model, which represents an applied torque to the anatomical valve chords. A range of mechanical model hysteresis states were investigated to find a model that best matches reported animal data of chord movement during a heartbeat. The study is limited by the use of one dataset found in the literature due to the highly invasive nature of getting this data. However, results clearly highlight fundamental physiological issues, such as the damping and chord stiffness changing within one cardiac cycle, that would be directly represented in any mitral valve model and affect behaviour in dysfunction. Very good correlation was achieved between modeled and experimental valve angle with 1–10% absolute error in the best case, indicating good promise for future simulation of cardiac valvular dysfunction, such as mitral regurgitation or stenosis. In particular, the model provides a pathway to capturing these dysfunctions in terms of modeled stiffness or elastance that can be directly related to anatomical, structural defects and dysfunction. [Copyright &y& Elsevier]

العنوان البديل: Degeneración valvular mixomatosa. Una mirada a los últimos avances en todos los aspectos de la enfermedad.
Degeneração valvar mixomatosa. Um olhar nos últimos avanços em todos os aspectos da doença.

المؤلفون: Reyes-Mantilla, Juan Pablo¹, Gómez-Torres, Fabián Alejandro¹, Sánchez-Pico, Favio¹, Albarracín-Navas, Javier Hernando¹, Toledo-Cáceres, Édgar Hernando¹

المصدر: Spei Domus. ene-jun2013, Vol. 9 Issue 18, p49-58. 10p.

مصطلحات موضوعية: *MITRAL valve diseases, *DEGENERATION (Pathology), *HEART diseases, *CANIDAE, *MUCOPOLYSACCHARIDES, *DISEASES

الملخص (بالإنجليزية): This review article is an analysis of the most recent published scientific articles about myxomatous valve degeneration (MVD) and was conducted over a five month period. The aim of this review is to consolidate information about the most recent medical developments in regards to myxomatous degeneration in the mitral valve. The authors of this article reached a consensus on both the development of the disease and the most effective type of diagnosis and treatment that is available today. Myxomatous valve degeneration is the most common heart disease in the canine population. It is identified by a loss of mechanical integrity in the heart due to structural changes in the valvular components. Degenerative changes occur due to an accumulation of mucopolysaccharides in the leaflets and chordae which affect the proper operation of the valve apparatus. This is caused by faulty coaptation of the leaflets, resulting in mitral or tricuspid regurgitation, dilated ventricles and annuli, which are lesions that eventually cause the rupture of the chordae tendineae, leading to complications or possibly death. Due to the gradual progression of the disease and the presence or absence of clinical signs, it is very important that veterinarians accurately diagnose and follow-up on these patients in order to achieve stabilization and provide a suitable prognosis and treatment plan. The current ideal treatment of the disease is a low-sodium diet, administration of the ACE inhibitor (angiotensin-converting-enzyme inhibitor) spironolactone and a diuretic in order to reduce the presence of pulmonary edema and avoid the progression of the disease to congestive heart failure. [ABSTRACT FROM AUTHOR]

Abstract (Spanish): Este artículo de revisión se realizó durante un periodo de cinco meses, en el que se incluyeron los últimos avances publicados en artículos científicos. Se logró realizar un consenso en cuanto al desarrollo de la enfermedad, el tipo de diagnóstico más adecuado y el tratamiento que mejores resultados está mostrando en la actualidad. El objetivo de esta revisión fue conocer las últimas actualizaciones acerca de la degeneración valvular mixomatosa. La degeneración valvular mixomatosa es la enfermedad cardiaca más común en la población canina, en la cual hay una pérdida de la integridad mecánica debido a cambios estructurales en los componentes valvulares. Los cambios se deben a una acumulación de mucopolisacáridos en las cuerdas tendinosas y las valvas, lo cual inicia con fallas en la coaptación de las valvas, generando una regurgitación mitral o tricuspidiana, dilatación de los ventrículos y del anillo valvular, llevando a complicaciones o muerte del paciente. Debido al progreso gradual de las lesiones en la enfermedad y a la manifestación o no de signos clínicos, el diagnóstico exacto y seguimiento apropiado de estos pacientes es de gran importancia para los médicos veterinarios con el fin de pronosticar e instaurar el tratamiento adecuado. El mejor tratamiento en la actualidad para la enfermedad consiste en una dieta baja en sodio, administración de un IECA (Inhibidor de la Enzima Convertidora de Angiotensina), espironolactona y un diurético con el fin de disminuir la presencia de signos asociados al edema pulmonar y evitar el progreso de esta a una insuficiencia cardiaca congestiva. [ABSTRACT FROM AUTHOR]

Abstract (Portuguese): Este artigo de revisâo se realizou durante um período de cinco meses. Incluíram-se, neste, os últimos avanços publicados em artigos científicos. Conseguiu-se realizar um consenso quanto ao desenvolvimento da doença, ao tipo de diagnóstico mais adequado e ao tratamento que melhores resultados está mostrando na atualidade. O objetivo desta revisao foi conhecer as últimas atualizaçoes sobre a degeneraçâo valvular mixomatosa. A degeneraçâo valvar mixomatosa é a doença cardíaca mais comum na populaçâo canina, na qual há uma perda da integridade mecánica devido a mudanças estruturais nos componentes valvulares. As mudanças se devem a uma acumulaçâo de mucopolisacáridos nas cordas tendíneas e nas valvas as quais iniciam com falhas na coaptaçâo das valvas gerando uma regurgitaçâo mitral ou tricuspidiana, dilataçâo dos ventrículos e do anel valvular, levando a complicaçoes ou morte do paciente. Devido ao progresso gradual das lesoes na doença e à manifestaçâo ou nao de signos clínicos, o diagnóstico exato e seguimento apropriado desses pacientes é de grande importáncia para os médicos veterinários com o objetivo de prognosticar e instaurar o tratamento adequado. O melhor tratamento na atualidade para a doença consiste em uma dieta baixa em sódio, administraçâo de um Inibidor da Enzima Convertidora de Angiotensima (IECA), espironolactona e um diurético a fim de diminuir a presença de signos associados a edema pulmonar e evitar o progresso desta a uma insuficiencia cardíaca congestiva. [ABSTRACT FROM AUTHOR]

المؤلفون: Nabati, Maryam¹, Tabiban, Sasan¹, Babaei, Ahmad²

المصدر: Journal of Mazandaran University of Medical Sciences (JMUMS). Jun2012, Vol. 22 Issue 89, p116-120. 5p.

مصطلحات موضوعية: *CONGENITAL disorders, *MITRAL valve diseases, *RARE diseases, *MEDICAL literature, *HEART diseases, *PEDIATRIC diagnosis, *ECHOCARDIOGRAPHY, *FOLLOW-up studies (Medicine)

مستخلص: Accessory mitral valve tissue is a rare congenital malformation that has been reported in the literature in approximately 130 cases. This condition could be found isolated or in combination with other cardiac anomalies and is usually diagnosed in childhood. It is in differential diagnosis with other cardiac masses as tumors or vegetations. In this article a 27 year old asymptomatic female is presented who referred to hospital for the evaluation of cardiac mass. Transthoracic and then transesophageal echocardiography revealed a mass in LVOT which was a membranous type of accessory mitral valve tissue without obstruction in LVOT. Echocardiography is highly beneficial in differential diagnosis and planning for surgery or medical follow-up in such rare patients. [ABSTRACT FROM AUTHOR]

المؤلفون: SOYLU, Korhan¹ korhansoylu@yahoo.com, CAHIT, Kocakavak¹, SABRI, Demircan¹, DIYAR, Köprülü¹, SERKAN, Yüksel¹, İHSAN, Dursun¹, KENAN, Durna¹, MUSTAFA, Yaz#x0131;cı¹, MAHMUT, Şahin¹, ÖZCAN, Y#x0131;lmaz¹

المصدر: Balkan Military Medical Review. 2011, Vol. 14 Issue 1, p1-13. 13p.

مصطلحات موضوعية: *MITRAL valve insufficiency, *MITRAL valve diseases, *REVASCULARIZATION (Surgery), *CORONARY disease, *HEART diseases

مستخلص: Objective: Although it is known that revascularization is useful for the treatment of patients with ischemic mitral regurgitation (MR), the effects of revascularization on MR have not been well examined. In this study, we aimed to show the effect of revascularization alone on patients with moderate schemic MR, quantitatively and prospectively. Methods: Forty-seven patients with moderate MR (2 to 3 +) who were offered revascularization due to the diagnosis of coronary artery disease were enrolled in the study. Patients were divided into three groups according to their treatments. Patients who underwent percutaneous coronary intervention (PCI) were defined as group 1 (n=18), patients who underwent surgical revascularization (CABG) as group 2 (n=17) and patients who received medical treatment as group 3 (n=12). Transthoracic echocardiography (TTE) was performed on all patients at the beginning of the study, and after three months. Semi-quantitative (I-IV) and quantitative (EOA, RV, and RF) parameters were calculated for MR grading. Results: MR parameters of three groups were similar for TTE, performed at the beginning of the study. When the initial and the third month MR parameters of patients were compared, there was a significant decrease in group 1 in effective orifice area (EOA) (p=0.002), regurgitant volume (RV) (p=0.005), regurgitant fraction (RF) (p=0.002) and semi-quantitative MR (p=0.002). There was also a similar significant decrease in group 2 in EOA (p=0.002), RV (p=0.001), RF (p=0.001) and semi-quantitative MR (p=0.005) grades. However, EOA (p=0.10), RV (p=0.19), RF (p=0.07) and semi-quantitative MR grades (p=0.48) of group 3 patients were found to be similar to initial parameters. There was no difference between groups when residual MR grades at the third month were compared with each other (p>0.05). Conclusion: Our study showed that percutaneous or surgical revascularization significantly improved MR parameters, on the other hand there was no difference obtained with medical treatment. However, it was found that revascularization alone was related with important residual MR in the treatment of patients with ischemic MR. For this reason it can be suggested that revascularization is effective but not sufficient for the treatment of patients with ischemic MR. [ABSTRACT FROM AUTHOR]