دورية أكاديمية
Biological response to purification and acid functionalization of carbon nanotubes
| العنوان: | Biological response to purification and acid functionalization of carbon nanotubes |
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| المؤلفون: | Figarol, Agathe, Pourchez, Jérémie, Boudard, Delphine, Forest, Valérie, Tulliani, Jean-Marc, Lecompte, Jean-Pierre, Cottier, Michèle, Bernache-Assollant, Didier, Grosseau, Philippe |
| المساهمون: | Centre Sciences des Processus Industriels et Naturels (SPIN-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT), Département PROcédés Poudres, Interfaces, Cristallisation et Ecoulements (PROPICE-ENSMSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-SPIN, Laboratoire Georges Friedel (LGF-ENSMSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre Ingénierie et Santé (CIS-ENSMSE), Institut Fédératif de Recherche en Sciences et Ingénierie de la Santé (IFRESIS), Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Centre National de la Recherche Scientifique (CNRS), Ingénierie des Biomatériaux et des Particules Inhalées (BIOPI-ENSMSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-CIS, Laboratoire Interdisciplinaire d'Etude des Nanoparticules Aérosolisées (LINA-ENSMSE), Dipartimento di Scienza dei Materiali ed Ingegneria Chimica, Politecnico di Torino = Polytechnic of Turin (Polito), Axe 2 : procédés de traitements de surface, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Jean Monnet, CHU de Saint Etienne, Politecnico di Torino, SPCTS, Centre Européen de la Céramique |
| المصدر: | ISSN: 1388-0764. |
| بيانات النشر: | HAL CCSD Springer Verlag |
| سنة النشر: | 2014 |
| المجموعة: | Université Jean Monnet – Saint-Etienne: HAL |
| مصطلحات موضوعية: | Carbon nanotubes, Health effects, Nanotoxicity, Surface functionalization, Oxidative stress, Inflammation, Cytotoxicity, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, [SDV.TOX]Life Sciences [q-bio]/Toxicology |
| الوصف: | The final publication is available at Springer via: http://link.springer.com/article/10.1007/s11051-014-2507-yTest ; International audience ; Acid functionalization has been considered as an easy way to enhance the dispersion and biodegradation of carbon nanotubes (CNT). However, inconsistencies between toxicity studies of acid functionalized CNT remain unexplained. This could be due to a joint effect of the main physicochemical modifications resulting from an acid functionalization: addition of surface acid groups and purification from catalytic metallic impurities. In this study, the impact on CNT biotoxicity of these two physiochemical features was assessed separately. The in vitro biological response of RAW 264.7 macrophages was evaluated after exposure to 15-240 µg x mL −1 of two types of multi-walled CNT. For each type of CNT (small: 20 nm diameter, and big: 90 nm diameter), three different surface chemical properties were studied (total of six CNT samples): pristine, acid functionalized and desorbed. Desorbed CNT were purified by the acid functionalization but presented a very low amount of surface acid groups due to a thermal treatment under vacuum. A Janus effect of acid functionalization with two opposite impacts is highlighted. The CNT purification decreased the overall toxicity, while the surface acid groups intensified it when present at a specific threshold. These acid groups especially amplified the pro-inflammatory response. The threshold mechanism which seemed to regulate the impact of acid groups should be further studied to determine its value and potential link to the other physicochemical state of the CNT. The results suggest that, for a safer-design approach, the benefit-risk balance of an acid functionalization has to be considered, depending on the CNT primary state of purification. Further research should be conducted in this direction. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-01017203; https://hal.science/hal-01017203Test; https://hal.science/hal-01017203/documentTest; https://hal.science/hal-01017203/file/AF-JNR-16-Orig.pdfTest |
| DOI: | 10.1007/s11051-014-2507-y |
| الإتاحة: | https://doi.org/10.1007/s11051-014-2507-yTest https://hal.science/hal-01017203Test https://hal.science/hal-01017203/documentTest https://hal.science/hal-01017203/file/AF-JNR-16-Orig.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.EC06360D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s11051-014-2507-y |
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