دورية أكاديمية

Shared heritability and functional enrichment across six solid cancers

التفاصيل البيبلوغرافية
العنوان: Shared heritability and functional enrichment across six solid cancers
المؤلفون: Jiang X., Finucane H. K., Schumacher F. R., Schmit S. L., Tyrer J. P., Han Y., Michailidou K., Lesseur C., Kuchenbaecker K. B., Dennis J., Conti D. V., Casey G., Gaudet M. M., Huyghe J. R., Albanes D., Aldrich M. C., Andrew A. S., Andrulis I. L., Anton-Culver H., Antoniou A. C., Antonenkova N. N., Arnold S. M., Aronson K. J., Arun B. K., Bandera E. V., Barkardottir R. B., Barnes D. R., Batra J., Beckmann M. W., Benitez J., Benlloch S., Berchuck A., Berndt S. I., Bickeboller H., Bien S. A., Blomqvist C., Boccia S., Bogdanova N. V., Bojesen S. E., Bolla M. K., Brauch H., Brenner H., Brenton J. D., Brook M. N., Brunet J., Brunnstrom H., Buchanan D. D., Burwinkel B., Butzow R., Cadoni G., Caldes T., Caligo M. A., Campbell I., Campbell P. T., Cancel-Tassin G., Cannon-Albright L., Campa D., Caporaso N., Carvalho A. L., Chan A. T., Chang-Claude J., Chanock S. J., Chen C., Christiani D. C., Claes K. B. M., Claessens F., Clements J., Collee J. M., Correa M. C., Couch F. J., Cox A., Cunningham J. M., Cybulski C., Czene K., Daly M. B., deFazio A., Devilee P., Diez O., Gago-Dominguez M., Donovan J. L., Dork T., Duell E. J., Dunning A. M., Dwek M., Eccles D. M., Edlund C. K., Edwards D. R. V., Ellberg C., Evans D. G., Fasching P. A., Ferris R. L., Liloglou T., Figueiredo J. C., Fletcher O., Fortner R. T., Fostira F., Franceschi S., Friedman E., Gallinger S. J., Ganz P. A., Garber J., Garcia-Saenz J. A., Gayther S. A., Giles G. G., Godwin A. K., Goldberg M. S., Goldgar D. E., Goode E. L., Goodman M. T., Goodman G., Grankvist K., Greene M. H., Gronberg H., Gronwald J., Guenel P., Hakansson N., Hall P., Hamann U., Hamdy F. C., Hamilton R. J., Hampe J., Haugen A., Heitz F., Herrero R., Hillemanns P., Hoffmeister M., Hogdall E., Hong Y. -C., Hopper J. L., Houlston R., Hulick P. J., Hunter D. J., Huntsman D. G., Idos G., Imyanitov E. N., Ingles S. A., Isaacs C., Jakubowska A., James P., Jenkins M. A., Johansson M., John E. M., Joshi A. D., Kaneva R., Karlan B. Y., Kelemen L. E., Kuhl T., Khaw K. -T., Khusnutdinova E., Kibel A. S., Kiemeney L. A., Kim J., Kjaer S. K., Knight J. A., Kogevinas M., Kote-Jarai Z., Koutros S., Kristensen V. N., Kupryjanczyk J., Lacko M., Lam S., Lambrechts D., Landi M. T., Lazarus P., Le N. D., Lee E., Lejbkowicz F., Lenz H. -J., Leslie G., Lessel D., Lester J., Levine D. A., Li L., Li C. I., Lindblom A., Lindor N. M., Liu G., Loupakis F., Lubinski J., Maehle L., Maier C., Mannermaa A., Marchand L. L., Margolin S., May T., McGuffog L., Meindl A., Middha P., Miller A., Milne R. L., MacInnis R. J., Modugno F., Montagna M., Moreno V., Moysich K. B., Mucci L., Muir K., Mulligan A. M., Nathanson K. L., Neal D. E., Ness A. R., Neuhausen S. L., Nevanlinna H., Newcomb P. A., Newcomb L. F., Nielsen F. C., Nikitina-Zake L., Nordestgaard B. G., Nussbaum R. L., Offit K., Olah E., Olama A. A. A., Olopade O. I., Olshan A. F., Olsson H., Osorio A., Pandha H., Park J. Y., Pashayan N., Parsons M. T., Pejovic T., Penney K. L., Peters W. H. M., Phelan C. M., Phipps A. I., Plaseska-Karanfilska D., Pring M., Prokofyeva D., Radice P., Stefansson K., Ramus S. J., Raskin L., Rennert G., Rennert H. S., van Rensburg E. J., Riggan M. J., Risch H. A., Risch A., Roobol M. J., Rosenstein B. S., Rossing M. A., De Ruyck K., Saloustros E., Sandler D. P., Sawyer E. J., Schabath M. B., Schleutker J., Schmidt M. K., Setiawan V. W., Shen H., Siegel E. M., Sieh W., Singer C. F., Slattery M. L., Sorensen K. D., Southey M. C., Spurdle A. B., Stanford J. L., Stevens V. L., Stintzing S., Stone J., Sundfeldt K., Sutphen R., Swerdlow A. J., Tajara E. H., Tangen C. M., Tardon A., Taylor J. A., Teare M. D., Teixeira M. R., Terry M. B., Terry K. L., Thibodeau S. N., Thomassen M., Bjorge L., Tischkowitz M., Toland A. E., Torres D., Townsend P. A., Travis R. C., Tung N., Tworoger S. S., Ulrich C. M., Usmani N., Vachon C. M., Van Nieuwenhuysen E., Vega A., Aguado-Barrera M. E., Wang Q., Webb P. M., Weinberg C. R., Weinstein S., Weissler M. C., Weitzel J. N., West C. M. L., White E., Whittemore A. S., Wichmann H. -E., Wiklund F., Winqvist R., Wolk A., Woll P., Woods M., Wu A. H., Wu X., Yannoukakos D., Zheng W., Zienolddiny S., Ziogas A., Zorn K. K., Lane J. M., Saxena R., Thomas D., Hung R. J., Diergaarde B., McKay J., Peters U., Hsu L., Garcia-Closas M., Eeles R. A., Chenevix-Trench G., Brennan P. J., Haiman C. A., Simard J., Easton D. F., Gruber S. B., Pharoah P. D. P., Price A. L., Pasaniuc B., Amos C. I., Kraft P., Lindstrom S.
المساهمون: Jiang, X., Finucane, H. K., Schumacher, F. R., Schmit, S. L., Tyrer, J. P., Han, Y., Michailidou, K., Lesseur, C., Kuchenbaecker, K. B., Dennis, J., Conti, D. V., Casey, G., Gaudet, M. M., Huyghe, J. R., Albanes, D., Aldrich, M. C., Andrew, A. S., Andrulis, I. L., Anton-Culver, H., Antoniou, A. C., Antonenkova, N. N., Arnold, S. M., Aronson, K. J., Arun, B. K., Bandera, E. V., Barkardottir, R. B., Barnes, D. R., Batra, J., Beckmann, M. W., Benitez, J., Benlloch, S., Berchuck, A., Berndt, S. I., Bickeboller, H., Bien, S. A., Blomqvist, C., Boccia, S., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Brauch, H., Brenner, H., Brenton, J. D., Brook, M. N., Brunet, J., Brunnstrom, H., Buchanan, D. D., Burwinkel, B., Butzow, R., Cadoni, G., Caldes, T., Caligo, M. A., Campbell, I., Campbell, P. T., Cancel-Tassin, G., Cannon-Albright, L., Campa, D., Caporaso, N., Carvalho, A. L., Chan, A. T., Chang-Claude, J., Chanock, S. J., Chen, C., Christiani, D. C., Claes, K. B. M., Claessens, F., Clements, J., Collee, J. M., Correa, M. C., Couch, F. J., Cox, A., Cunningham, J. M., Cybulski, C., Czene, K., Daly, M. B., Defazio, A., Devilee, P., Diez, O., Gago-Dominguez, M., Donovan, J. L., Dork, T., Duell, E. J., Dunning, A. M., Dwek, M., Eccles, D. M., Edlund, C. K., Edwards, D. R. V., Ellberg, C., Evans, D. G., Fasching, P. A., Ferris, R. L., Liloglou, T., Figueiredo, J. C., Fletcher, O., Fortner, R. T., Fostira, F., Franceschi, S., Friedman, E., Gallinger, S. J., Ganz, P. A.
سنة النشر: 2019
المجموعة: ARPI - Archivio della Ricerca dell'Università di Pisa
مصطلحات موضوعية: Breast Neoplasm, Case-Control Studie, Colorectal Neoplasm, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Head and Neck Neoplasm, Human, Lung Neoplasm, Male, Mental Disorder, Neoplasm Protein, Ovarian Neoplasm, Phenotype, Polymorphism, Single Nucleotide, Prostatic Neoplasm, Smoking, Inheritance Patterns
الوصف: Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r g = 0.57, p = 4.6 × 10 −8 ), breast and ovarian cancer (r g = 0.24, p = 7 × 10 −5 ), breast and lung cancer (r g = 0.18, p=1.5 × 10 −6 ) and breast and colorectal cancer (r g = 0.15, p = 1.1 × 10 −4 ). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
نوع الوثيقة: article in journal/newspaper
وصف الملف: STAMPA
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30683880; info:eu-repo/semantics/altIdentifier/wos/WOS:000456696700007; volume:10; issue:1; numberofpages:23; journal:NATURE COMMUNICATIONS; https://hdl.handle.net/11568/997804Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85060528251; https://www.nature.com/articles/s41467-018-08054-4Test
DOI: 10.1038/s41467-018-08054-4
الإتاحة: https://doi.org/10.1038/s41467-018-08054-4Test
https://hdl.handle.net/11568/997804Test
https://www.nature.com/articles/s41467-018-08054-4Test
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.99B068B4
قاعدة البيانات: BASE