التفاصيل البيبلوغرافية
| العنوان: |
Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma. |
| المؤلفون: |
Tejera-Vaquerizo, Antonio1 antoniotejera@aedv.es, Nagore, Eduardo2 eduardo_nagore@ono.com, Puig, Susana3 susipuig@gmail.com, Robert, Caroline4 caroline.robert@gustaveroussy.fr, Saiag, Philippe5 Philippe.saiag@uvsq.fr, Martín-Cuevas, Paula1 paulamcuevas@hotmail.com, Gallego, Elena6 elenag313@yahoo.es, Herrera-Acosta, Enrique1 eherreraacosta@gmail.com, Aguilera, José1 jaguilera@uma.es, Malvehy, Josep3 jmalvehy@gmail.com, Carrera, Cristina3 criscarrer@yahoo.es, Cavalcanti, Andrea7 Andrea.cavalcanti@gustaveroussy.fr, Rull, Ramón8 rrull@clinic.ub.es, Vilalta-Solsona, Antonio3 vilalta@cancerpiel.com, Lannoy, Emilie9 Emilie.lannoy@gustaveroussy.fr, Boutros, Celine4 celine.boutros@gustaveroussy.fr, Benannoune, Naima4 naima.benannoune@gustaveroussy.fr, Tomasic, Gorana10 gorana.tomasic@gustaveroussy.fr, Aegerte, Philippe11 Philippe.aegerter@apr.aphp.fr, Vidal-Sicart, Sergi12 svidal@clinic.ub.es |
| المصدر: |
European Journal of Cancer. Sep2015, Vol. 51 Issue 13, p1780-1793. 14p. |
| مصطلحات موضوعية: |
*MELANOMA prognosis, *SKIN tumors, *CONFIDENCE intervals, *HEAD, *HOSPITALS, *LONGITUDINAL method, *MEDICAL cooperation, *NECK, *REGRESSION analysis, *RESEARCH, *SURVIVAL, *TIME, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *SENTINEL lymph node biopsy, *PROGNOSIS |
| مستخلص: |
Introduction In patients with primary cutaneous melanoma, there is generally a delay between excisional biopsy of the primary tumour and sentinel-node biopsy. The objective of this study is to analyse the prognostic implications of this delay. Patients and method This was an observational, retrospective, cohort study in four tertiary referral hospitals. A total of 1963 patients were included. The factor of interest was the interval between the date of the excisional biopsy of the primary melanoma and the date of the sentinel-node biopsy (delay time) in the prognosis. The primary outcome was melanoma-specific survival and disease-free survival. Results A delay time of 40 days or less (hazard ratio (HR), 1.7; confidence interval (CI), 1.2–2.5) increased Breslow thickness (Breslow ⩾2 mm, HR, >3.7; CI, 1.4–10.7), ulceration (HR, 1.6; CI, 1.1–2.3), sentinel-node metastasis (HR, 2.9; CI, 1.9–4.2), and primary melanoma localised in the head or neck were independently associated with worse melanoma-specific survival (all P < 0.03). The stratified analysis showed that the effect of delay time was at the expense of the patients with a negative sentinel-node biopsy and without regression. Conclusion Early sentinel-node biopsy is associated with worse survival in patients with cutaneous melanoma. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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