المؤلفون: Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C, Cookson, William O C, Altmüller, Janine, Ang, Wei, Barr, R Graham, Beaty, Terri H, Becker, Allan B, Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bønnelykke, Klaus, Boomsma, Dorret I, Bouzigon, Emmanuelle, Brightling, Christopher E, Brossard, Myriam, Brusselle, Guy G, Burchard, Esteban, Burkart, Kristin M, Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Couto Alves, Alexessander, Curtin, John A, Custovic, Adnan, Daley, Denise, de Jongste, Johan C, Del-Rio-Navarro, Blanca E, Donohue, Kathleen M, Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G, Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A, Freidin, Maxim B, Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A, Koppelman, Gerard H, Nieuwenhuis, Maartje A E, Postma, Dirkje S, Vonk, Judith M, Weiss, Scott T

المصدر: Demenais , F , Margaritte-Jeannin , P , Barnes , K C , Cookson , W O C , Altmüller , J , Ang , W , Barr , R G , Beaty , T H , Becker , A B , Beilby , J , Bisgaard , H , Bjornsdottir , U S , Bleecker , E , Bønnelykke , K , Boomsma , D I , Bouzigon , E , Brightling , C E , Brossard , M , Brusselle , G G , Burchard , E , Burkart , K M , Bush , A , ....

مصطلحات موضوعية: GENOME-WIDE ASSOCIATION, AUTOIMMUNE-DISEASE, HAY-FEVER, VARIANTS, METAANALYSIS, EXPRESSION, GENE, POPULATIONS, TWINS

الوصف: We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.

العلاقة: https://research.rug.nl/en/publications/58fd353c-a21b-404e-a85e-714dabbf0f6bTest

الإتاحة: https://doi.org/10.1038/s41588-017-0014-7Test
https://hdl.handle.net/11370/58fd353c-a21b-404e-a85e-714dabbf0f6bTest
https://research.rug.nl/en/publications/58fd353c-a21b-404e-a85e-714dabbf0f6bTest
https://repository.arizona.edu/bitstream/10150/627870/1/TAGC_meta-analysis_paper_28_Juin_2017.pdfTest

المؤلفون: Marenholz, Ingo, Esparza-Gordillo, Jorge, Rueschendorf, Franz, Bauerfeind, Anja, Strachan, David P., Spycher, Ben D., Baurecht, Hansjoerg, Margaritte-Jeannin, Patricia, Saaf, Annika, Kerkhof, Marjan, Ege, Markus, Baltic, Svetlana, Matheson, Melanie C., Li, Jin, Michel, Sven, Ang, Wei Q., McArdle, Wendy, Arnold, Andreas, Homuth, Georg, Demenais, Florence, Bouzigon, Emmanuelle, Soderhall, Cilla, Pershagen, Goran, de Jongste, Johan C., Postma, Dirkje S., Braun-Fahrlaender, Charlotte, Horak, Elisabeth, Ogorodova, Ludmila M., Puzyrev, Valery P., Bragina, Elena Yu, Hudson, Thomas J., Morin, Charles, Duffy, David L., Marks, Guy B., Robertson, Colin F., Montgomery, Grant W., Musk, Bill, Thompson, Philip J., Martin, Nicholas G., James, Alan, Sleiman, Patrick, Toskala, Elina, Rodriguez, Elke, Foelster-Holst, Regina, Franke, Andre, Lieb, Wolfgang, Gieger, Christian, Heinzmann, Andrea, Rietschel, Ernst, Keil, Thomas, Cichon, Sven, Noethen, Markus M., Pennell, Craig E., Sly, Peter D., Schmidt, Carsten O., Matanovic, Anja, Schneider, Valentin, Heinig, Matthias, Huebner, Norbert, Holt, Patrick G., Lau, Susanne, Kabesch, Michael, Weidinger, Stefan, Hakonarson, Hakon, Ferreira, Manuel A. R., Laprise, Catherine, Freidin, Maxim B., Genuneit, Jon, Koppelman, Gerard H., Melen, Erik, Dizier, Marie-Helene, Henderson, A. John, Lee, Young Ae

المصدر: Marenholz , I , Esparza-Gordillo , J , Rueschendorf , F , Bauerfeind , A , Strachan , D P , Spycher , B D , Baurecht , H , Margaritte-Jeannin , P , Saaf , A , Kerkhof , M , Ege , M , Baltic , S , Matheson , M C , Li , J , Michel , S , Ang , W Q , McArdle , W , Arnold , A , Homuth , G , Demenais , F , Bouzigon , E , Soderhall , C , Pershagen , G , de Jongste , ....

مصطلحات موضوعية: JUVENILE MYOCLONIC EPILEPSY, FOOD ALLERGY, FILAGGRIN MUTATIONS, BIRTH COHORT, HAY-FEVER, GENOMEWIDE ASSOCIATION, CHROMOSOME 11Q13, CHILDHOOD ASTHMA, DERMATITIS, RISK

الوصف: Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P = 2.1 x 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P = 5.3 x 10(-9)). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/d95a648a-1497-4cb1-ae27-ea2b4e7a7197Test

الإتاحة: https://doi.org/10.1038/ncomms9804Test
https://hdl.handle.net/11370/d95a648a-1497-4cb1-ae27-ea2b4e7a7197Test
https://research.rug.nl/en/publications/d95a648a-1497-4cb1-ae27-ea2b4e7a7197Test
https://pure.rug.nl/ws/files/28522294/ncomms9804.pdfTest