المؤلفون: Cohen, Jarish N, Gouirand, Victoire, Macon, Courtney E, Lowe, Margaret M, Boothby, Ian C, Moreau, Joshua M, Gratz, Iris K, Stoecklinger, Angelika, Weaver, Casey T, Sharpe, Arlene H, Ricardo-Gonzalez, Roberto R, Rosenblum, Michael D

المصدر: Science Immunology. 9(91)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Immunology, Autoimmune Disease, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Skin, Humans, Immune Privilege, T-Lymphocytes, Regulatory, Hair Follicle, Interleukin-2, Stem Cell Niche, Clinical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3wg33128Test

المؤلفون: Moreau, Joshua M, Gouirand, Victoire, Rosenblum, Michael D

المصدر: JID Innovations. 1(2)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Underpinning research, Aetiology, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Skin, Inflammatory and immune system, AD, atopic dermatitis, BM, basement membrane, DC, dendritic cell, DETC, dendritic epidermal γδ T cell, ECM, extracellular matrix, HF, hair follicle, JC, John Cunningham, LAD, leukocyte adhesion deficiency, PML, progressive multifocal leukoencephalopathy, Th, T helper, Treg, regulatory T cell, Trm, tissue-resident memory

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4j3489sdTest

المؤلفون: Mathur, Anubhav N, Zirak, Bahar, Boothby, Ian C, Tan, Madge, Cohen, Jarish N, Mauro, Thea M, Mehta, Pooja, Lowe, Margaret M, Abbas, Abul K, Ali, Niwa, Rosenblum, Michael D

المصدر: Immunity. 50(3)

مصطلحات موضوعية: Medical Biotechnology, Biomedical and Clinical Sciences, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Regenerative Medicine, Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Inflammatory and immune system, Skin, Animals, Cell Differentiation, Chemokine CXCL5, Epidermal Cells, Epidermis, Epithelial Cells, Hair, Hair Follicle, Interleukin-17, Mice, Mice, Inbred C57BL, Regeneration, Stem Cells, T-Lymphocytes, Regulatory, CXCL5, IL-17, Lrg5, barrier repair, epidermis, hair follicle stem cells, regulatory T cell, skin, stem cell, Immunology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/86d5v7xxTest
https://escholarship.org/content/qt86d5v7xx/qt86d5v7xx.pdfTest

المؤلفون: Ali, Niwa, Zirak, Bahar, Rodriguez, Robert Sanchez, Pauli, Mariela L, Truong, Hong-An, Lai, Kevin, Ahn, Richard, Corbin, Kaitlin, Lowe, Margaret M, Scharschmidt, Tiffany C, Taravati, Keyon, Tan, Madeleine R, Ricardo-Gonzalez, Roberto R, Nosbaum, Audrey, Bertolini, Marta, Liao, Wilson, Nestle, Frank O, Paus, Ralf, Cotsarelis, George, Abbas, Abul K, Rosenblum, Michael D

المصدر: Cell. 169(6)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Immunology, Regenerative Medicine, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, 1.1 Normal biological development and functioning, Underpinning research, Inflammatory and immune system, Animals, Epithelial Cells, Hair Follicle, Humans, Inflammation, Jagged-1 Protein, Mice, Stem Cells, T-Lymphocytes, Regulatory, Jagged 1, Notch, alopecia areata, hair, hair follicle stem cell, hair regeneration, regulatory T cell, skin, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9w95h47nTest
https://escholarship.org/content/qt9w95h47n/qt9w95h47n.pdfTest

المؤلفون: Scharschmidt, Tiffany C, Vasquez, Kimberly S, Pauli, Mariela L, Leitner, Elizabeth G, Chu, Kevin, Truong, Hong-An, Lowe, Margaret M, Rodriguez, Robert Sanchez, Ali, Niwa, Laszik, Zoltan G, Sonnenburg, Justin L, Millar, Sarah E, Rosenblum, Michael D

المصدر: Cell Host & Microbe. 21(4)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Immunology, Pediatric, Microbiome, 2.1 Biological and endogenous factors, Aetiology, Skin, Animals, Chemokine CCL20, Hair Follicle, Immune Tolerance, Mice, Microbiota, Morphogenesis, Receptors, CCR6, Symbiosis, T-Lymphocytes, Regulatory, commensal-specific immune tolerance, hair follicles, migration, regulatory T cells, skin commensal microbes, tissue development, Microbiology, Medical Microbiology, Biochemistry and cell biology, Medical microbiology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5528r03rTest
https://escholarship.org/content/qt5528r03r/qt5528r03r.pdfTest

المؤلفون: Sanchez Rodriguez, Robert, Pauli, Mariela L, Neuhaus, Isaac M, Yu, Siegrid S, Arron, Sarah T, Harris, Hobart W, Yang, Sara Hsin-Yi, Anthony, Bryan A, Sverdrup, Francis M, Krow-Lucal, Elisabeth, MacKenzie, Tippi C, Johnson, David S, Meyer, Everett H, Löhr, Andrea, Hsu, Andro, Koo, John, Liao, Wilson, Gupta, Rishu, Debbaneh, Maya G, Butler, Daniel, Huynh, Monica, Levin, Ethan C, Leon, Argentina, Hoffman, William Y, McGrath, Mary H, Alvarado, Michael D, Ludwig, Connor H, Truong, Hong-An, Maurano, Megan M, Gratz, Iris K, Abbas, Abul K, Rosenblum, Michael D

المصدر: The Journal of clinical investigation. 124(3)

مصطلحات موضوعية: Hair Follicle, Cells, Cultured, Skin, Animals, Mice, Inbred NOD, Humans, Mice, Psoriasis, Receptors, Antigen, T-Cell, Antigens, CD, Interleukin-17, Cell Proliferation, Cell Movement, Immunologic Memory, Phenotype, Adult, Aged, Middle Aged, Female, Male, T-Lymphocytes, Regulatory, Forkhead Transcription Factors, Receptors, CCR7, Young Adult, Clinical Research, Autoimmune Disease, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Aetiology, Underpinning research, Inflammatory and immune system, Medical and Health Sciences, Immunology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6mq2w70qTest

المؤلفون: Gratz, Iris K, Truong, Hong-An, Yang, Sara Hsin-Yi, Maurano, Megan M, Lee, Karim, Abbas, Abul K, Rosenblum, Michael D

المصدر: The Journal of Immunology. 190(9)

مصطلحات موضوعية: Prevention, Underpinning research, Aetiology, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Inflammatory and immune system, Animals, Antigens, Autoimmunity, CD4-Positive T-Lymphocytes, Hair Follicle, Immunologic Memory, Interleukin-2 Receptor alpha Subunit, Lymph Nodes, Mice, Mice, Inbred BALB C, Receptors, Interleukin-7, Skin, T-Lymphocytes, Regulatory, Immunology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7041x5f0Test

المؤلفون: Dunstan, Robert W., Salte, Katherine M., Todorović, Viktor, Lowe, Margaret, Wetter, Joseph B., Harms, Paul W., Burney, Richard E., Scott, Victoria E., Smith, Kathleen M., Rosenblum, Michael D., Gudjonsson, Johann E., Honore, Prisca

مصطلحات موضوعية: pathogenesis, hair follicle, diseases, Hidradenitis suppurativa, inflammatory skin, Dentistry, Health Sciences

وصف الملف: application/pdf

العلاقة: Dunstan, Robert W.; Salte, Katherine M.; Todorović, Viktor; Lowe, Margaret; Wetter, Joseph B.; Harms, Paul W.; Burney, Richard E.; Scott, Victoria E.; Smith, Kathleen M.; Rosenblum, Michael D.; Gudjonsson, Johann E.; Honore, Prisca (2021). "Histologic progression of acne inversa/hidradenitis suppurativa: Implications for future investigations and therapeutic intervention." Experimental Dermatology (6): 820-830.; https://hdl.handle.net/2027.42/168326Test; Experimental Dermatology; Melnik BC, Plewig G. Impaired Notch- MKP- 1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology. Exp Dermatol. 2013; 22 ( 3 ): 172 - 177.; Poli F, Wolkenstein P, Revuz J. Back and face involvement in hidradenitis suppurativa. Dermatology. 2010; 221 ( 2 ): 137 - 141.; Frew JW, Hawkes JE, Krueger JG. A systematic review and critical evaluation of immunohistochemical associations in hidradenitis suppurativa. F1000 Res. 2018; 7: 1923.; Plewig G, Kligman AM. The Anatomy of Follicles. Acne and Rosacea. Berlin, Heidelberg (Eds: G Plewig, AM Kligman ): Springer; 2000: 30 - 49.; Panteleyev AA. Functional anatomy of the hair follicle: the secondary hair germ. Exp Dermatol. 2018; 27 ( 7 ): 701 - 720.; Schneider MR, Paus R. Deciphering the functions of the hair follicle infundibulum in skin physiology and disease. Cell Tis Res. 2014; 358 ( 3 ): 697 - 704.; Amoh Y, Kanoh M, Niiyama S, et al. Human and mouse hair follicles contain both multipotent and monopotent stem cells. Cell Cycle. 2009; 8 ( 1 ): 176 - 177.; Yang L, Zhang S, Wang G. Keratin 17 in disease pathogenesis: from cancer to dermatoses. J Pathol. 2019; 247 ( 2 ): 158 - 165.; Commo S, Gaillard O, Bernard BA. The human hair follicle contains two distinct K19 positive compartments in the outer root sheath: a unifying hypothesis for stem cell reservoir? Differentiation. 2000; 66 ( 4- 5 ): 157 - 164.; Kanoh M, Amoh Y, Sato Y, Katsuoka K. Expression of the hair stem cell- specific marker nestin in epidermal and follicular tumors. Eur J Dermatol. 2008; 18 ( 5 ): 518 - 523.; Li L, Mignone J, Yang M, et al. Nestin expression in hair follicle sheath progenitor cells. Proc Natl Acad Sci. 2003; 100 ( 17 ): 9958 - 9961.; Bose A, Teh MT, Mackenzie I, Waseem A. Keratin K15 as a biomarker of epidermal stem cells. Inter J Mol Sci. 2013; 14 ( 10 ): 19385 - 19398.; Welch DR, Hurst DR. Beyond the primary tumor: progression, invasion, and metastasis. In: The Molecular Basis of Human Cancer. New York, NY: Humana Press; 2017: 203 - 216.; Maru GB, Gandhi K, Ramchandani A, Kumar G. The role of inflammation in skin cancer. In: Inflammation and Cancer. Basel, Switzerland: Springer; 2014: 437 - 469.; Selmer J, Skov T, Spelman L, Weedon D. Squamous cell carcinoma and keratoacanthomas are biologically distinct and can be diagnosed by light microscopy: a review. Histopathology. 2016; 69 ( 4 ): 535 - 541.; Ackerman AB. Differentiation of benign from malignant neoplasms by silhouette. Am J Dermatopath. 1989; 11 ( 4 ): 297 - 300.; Zouboulis CC, Desai N, Emtestam L, et al. European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa. J Euro Acad Dermatol Venereol. 2015; 29 ( 4 ): 619 - 644.; Burney RE. 35- year experience with surgical treatment of hidradenitis suppurativa. World J Surg. 2017; 41 ( 11 ): 2723 - 2730.; Kohorst JJ, Baum CL, Otley CC, et al. Surgical management of hidradenitis suppurativa: outcomes of 590 consecutive patients. Dermatol Surg. 2016; 42 ( 9 ): 1030 - 1040.; Lavogiez C, Delaporte E, Darras- Vercambre S, et al. Clinicopathological study of 13 cases of squamous cell carcinoma complicating hidradenitis suppurativa. Dermatology. 2010; 220 ( 2 ): 147 - 153.; Lee CN, Chen W, Hsu CK, Weng TT, Lee JY, Yang CC. Dissecting folliculitis (dissecting cellulitis) of the scalp: a 66- patient case series and proposal of classification. J Dtsch Dermatol Ges. 2018; 16 ( 10 ): 1219 - 1226.; Badaoui A, Reygagne P, Cavelier- Balloy B, et al. Dissecting cellulitis of the scalp: a retrospective study of 51 patients and review of literature. Br J Dermatol. 2016; 174 ( 2 ): 421 - 423.; BrÄ niÅ teanu DE, Molodoi A, Ciobanu D, et al. The importance of histopathologic aspects in the diagnosis of dissecting cellulitis of the scalp. Rom J Morphol Embryol. 2009; 50 ( 4 ): 719 - 724.; Deckers IE, Benhadou F, Koldijk MJ, et al. Inflammatory bowel disease is associated with hidradenitis suppurativa: results from a multicenter cross- sectional study. J Am Acad Dermatol. 2017; 76 ( 1 ): 49 - 53.; Jørgensen AH, Thomsen SF, Karmisholt KE, Ring HC. Clinical, microbiological, immunological and imaging characteristics of tunnels and fistulas in hidradenitis suppurativa and Crohn- s disease. Exp Dermatol. 2020; 29 ( 2 ): 118 - 123.; Tozer PJ, Lung P, Lobo AJ, et al. Pathogenesis of Crohn’s perianal fistula- understanding factors impacting on success and failure of treatment strategies. Aliment Pharm Ther. 2018; 48 ( 3 ): 260 - 269.; Frew JW, Hawkes JE, Krueger JG. A systematic review and critical evaluation of inflammatory cytokine associations in hidradenitis suppurativa. F1000 Res. 2018; 7: 1930.; Schlapbach C, Hänni T, Yawalkar N, Hunger RE. Expression of the IL- 23/Th17 pathway in lesions of hidradenitis suppurativa. J Am Acad Dermatol. 2011; 65 ( 4 ): 790 - 798.; Lima AL, Karl I, Giner T, et al. Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa. Br J Dermatol. 2016; 174 ( 3 ): 514 - 521.; Burgess DJ. Spatial transcriptomics coming of age. Nat Rev Genet. 2019; 20 ( 6 ): 317.; Saha S, Matthews DA, Bessant C. High throughput discovery of protein variants using proteomics informed by transcriptomics. Nucleic Acids Res. 2018; 46 ( 10 ): 4893 - 4902.; Theut Riis P, Thorlacius LR, Jemec GB. Investigational drugs in clinical trials for hidradenitis suppurativa. Expert Opin Investig Drug. 2018; 27 ( 1 ): 43 - 53.; Kimball AB, Okun MM, Williams DA, et al. Two phase 3 trials of adalimumab for hidradenitis suppurativa. N Engl J Med. 2016; 375 ( 5 ): 422 - 434.; Ring HC, Sigsgaard V, Thorsen J, et al. The microbiome of tunnels in hidradenitis suppurativa patients. J Euro Acad Dermatol and Venereol. 2019; 33 ( 9 ): 1775 - 1780.; Chen WT, Chi CC. Association of hidradenitis suppurativa with inflammatory bowel disease: A systematic review and meta- analysis. JAMA Dermatol. 2019; 155 ( 9 ): 1022 - 1027.; Hoffman LK, Ghias MH, Garg A, Hamzavi IH, Alavi A, Lowes MA. Major gaps in understanding and treatment of hidradenitis suppurativa. Semin Cutan Med Surg. 2017; 36 ( 2 ): 86 - 92.; Ralf Paus L, Kurzen H, Kurokawa I, et al. What causes hidradenitis suppurativa? Exp Dermatol. 2008; 17 ( 5 ): 455 - 456.; Alikhan A, Lynch PJ, Eisen DB. Hidradenitis suppurativa: a comprehensive review. J Am Acad Dermatol. 2009; 60 ( 4 ): 539 - 561.; Yu Ca C- W, Cook MG. Hidradenitis suppurativa: a disease of follicular epithelium, rather than apocrine glands. Br J of Dermatol. 1990; 122 ( 6 ): 763 - 769.; Prens E, Deckers I. Pathophysiology of hidradenitis suppurativa: an update. J Am Acad Dermatol. 2015; 73 ( 5 ): S8 - S11.; Sellheyer K, Krahl D. - Hidradenitis suppurativa- is acne inversa! An appeal to (finally) abandon a misnomer. Int J Dermatol. 2004; 7: 535 - 540.; Laffert MV, Helmbold P, Wohlrab J, Fiedler E, Stadie V, Marsch WC. Hidradenitis suppurativa (acne inversa): early inflammatory events at terminal follicles and at interfollicular epidermis. Exp Dermatol. 2010; 19 ( 6 ): 533 - 537.; Pink A, Anzengruber F, Navarini AA. Acne and hidradenitis suppurativa. Br J Dermatol. 2018; 178 ( 3 ): 619 - 631.; Chen W, Plewig G. Should hidradenitis suppurativa/acne inversa best be renamed as - dissecting terminal hair folliculitis- ? Exp Dermatol. 2017; 26 ( 6 ): 544 - 547.; Boer J, Weltevreden EF. Hidradenitis suppurativa or acne inversa. A clinicopathological study of early lesions. Br J Dermatol. 1996; 135 ( 5 ): 721 - 725.; Danby FW, Jemec GB, Marsch WC, Von Laffert M. Preliminary findings suggest hidradenitis suppurativa may be due to defective follicular support. Br J Dermatol. 2013; 168 ( 5 ): 1034 - 1039.; Fismen S, Ingvarsson G, Moseng D, et al. A clinical- pathological review of hidradenitis suppurativa: using immunohistochemistry one disease becomes two. Apmis. 2012; 120 ( 6 ): 433 - 440.; Jemec GB, Hansen U. Histology of hidradenitis suppurativa. J Am Acad Dermatol. 1996; 34 ( 6 ): 994 - 999.; Jemec GB, Thomsen BM, Hansen U. The homogeneity of hidradenitis suppurativa lesions: a histological study of intra- individual variation. APMIS. 1997; 105 ( 1- 6 ): 378 - 383.; Kamp S, Fiehn AM, Stenderup K, et al. Hidradenitis suppurativa: a disease of the absent sebaceous gland? Sebaceous gland number and volume are significantly reduced in uninvolved hair follicles from patients with hidradenitis suppurativa. Br J Dermatol. 2011; 164 ( 5 ): 1017 - 1022.; Kurokawa I, Nishijima S, Kusumoto K, Senzaki H, Shikata N, Tsubura A. Immunohistochemical study of cytokeratins in hidradenitis suppurativa (acne inversa). Int J Med Res. 2002; 30 ( 2 ): 131 - 136.; Kurzen H, Jung EG, Hartschuh W, Moll I, Franke WW, Moll R. Forms of epithelial differentiation of draining sinus in acne inversa (hidradenitis suppurativa). Br J Dermatol. 1999; 141 ( 2 ): 231 - 239.; Lafferty MV, Helmbold P, Wohlrab J, Fiedler E, Stadie V, Marsch WC. Hidradenitis suppurativa (acne inversa): early inflammatory events at terminal follicles and at interfollicular epidermis. Exp Dermatol. 2010; 19 ( 6 ): 533 - 537.; Saunte DM, Jemec GB. Hidradenitis suppurativa: advances in diagnosis and treatment. JAMA. 2017; 318 ( 20 ): 2019 - 2032.; Van der Zee HH, De Ruiter L, Boer J, et al. Alterations in leucocyte subsets and histomorphology in normal- appearing perilesional skin and early and chronic hidradenitis suppurativa lesions. Br J Dermatol. 2012; 166 ( 1 ): 98 - 106.; van der Zee HH, Laman JD, Boer J, Prens EP. Hidradenitis suppurativa: viewpoint on clinical phenotyping, pathogenesis and novel treatments. Exp Dermatol. 2012; 21 ( 10 ): 735 - 739.; von Laffert M, Stadie V, Wohlrab J, Marsch WC. Hidradenitis suppurativa/acne inversa: bilocated epithelial hyperplasia with very different sequelae. Br J Dermatol. 2011; 164 ( 2 ): 367 - 371.; Vossen AR, van der Zee HH, Prens EP. Hidradenitis Suppurativa: a systematic review integrating inflammatory pathways into a cohesive pathogenic model. Front Immunol. 2018; 9: 1 - 12.; Kurokawa I, Jemec GB, et al. What causes hidradenitis suppurativa? Viewpoint 4. Exp Dermatol. 2008; 17 ( 5 ): 462 - 465.; Smith MK, Nicholson CL, Parks- Miller A, Hamzavi IH. Hidradenitis suppurativa: an update on connecting the tracts. F1000Res. 2017; 6: 1272.; Boer J, Jemec GB. Mechanical stress and the development of pseudo- comedones and tunnels in Hidradenitis suppurativa/Acne inversa. Exp Dermatol. 2016; 25 ( 5 ): 396 - 397.; Gniadecki R, Jemec GB. Lipid raft- enriched stem cell- like keratinocytes in the epidermis, hair follicles and sinus tracts in hidradenitis suppurativa. Exp Dermatol. 2004; 13 ( 6 ): 361 - 363.; Frew JW, Navrazhina K, Marohn M, Lu CP, Krueger JG. Contribution of fibroblasts to tunnel formation and inflammation in hidradenitis suppurativa/Acne Inversa. Exp Dermatol. 2019; 28 ( 8 ): 1 - 6.; Freysz M, Jemec GB, Lipsker D. A systematic review of terms used to describe hidradenitis suppurativa. Br J Dermatol. 2015; 173 ( 5 ): 1298 - 1300.; Otberg N, Richter H, Schaefer H, Blume- Peytavi U, Sterry W, Lademann J. Variations of hair follicle size and distribution in different body sites. J Invest Dermatol. 2004; 122 ( 1 ): 14 - 19.; Vogt A, Hadam S, Heiderhoff M, et al. Morphometry of human terminal and vellus hair follicles. Exp Dermatol. 2007; 16 ( 11 ): 946 - 950.; Lu C, Fuchs E. Sweat gland progenitors in development, homeostasis, and wound repair. Cold Spring Harb. Perspect Med. 2014; 4 ( 2 ): a015222.

الإتاحة: https://doi.org/10.1111/exd.14273Test
https://hdl.handle.net/2027.42/168326Test

المؤلفون: Mathur, Anubhav N., Zirak, Bahar, Boothby, Ian C., Tan, Madge, Cohen, Jarish N., Mauro, Thea M., Mehta, Pooja, Lowe, Margaret, Abbas, Abul K., Ali, Niwa, Rosenblum, Michael D.

مصطلحات موضوعية: Chemokine CXCL5, integumentary system, Stem Cells, Interleukin-17, Cell Differentiation, Epithelial Cells, T-Lymphocytes, Regulatory, Article, Mice, Inbred C57BL, Mice, Epidermal Cells, Animals, Regeneration, Epidermis, Hair Follicle, Hair

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::bad0febc56455e7f13a7cb587758726fTest
https://europepmc.org/articles/PMC6507428Test/

المؤلفون: Rosenblum, Michael D.¹, Olasz, Edit B.², Yancey, Kim B.², Woodliff, Jeffrey E.¹, Lazarova, Zelmira², Gerber, Kimberly A.¹, Truitt, Robert L.¹ rtruitt@mcw.edu

المصدر: Journal of Investigative Dermatology. Nov2004, Vol. 123 Issue 5, p880-887. 8p.

مصطلحات موضوعية: *DERMATOLOGY, *EPITHELIUM, *EPITHELIAL cells, *HAIR follicles, *HLA histocompatibility antigens, *ANTIGENS