Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality?
| العنوان: | Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality? |
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| المؤلفون: | Lisa Pleyer, Peter Valent, Richard Greil |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 17, Iss 7, p 1009 (2016) |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, leukemic niche, Stem cell factor, Review, immunomodulation, lcsh:Chemistry, hemic and lymphatic diseases, bone marrow stem cell niche, Stem Cell Niche, lcsh:QH301-705.5, Spectroscopy, Hematopoietic stem cell, General Medicine, Computer Science Applications, Cell biology, Haematopoiesis, Leukemia, Myeloid, Acute, medicine.anatomical_structure, epithelial-to-mesenchymal transition, Adult stem cell, Signal Transduction, Epithelial-Mesenchymal Transition, myelodysplastic syndromes (MDS), mesenchymal stem cells (MSC), Clinical uses of mesenchymal stem cells, Bone Marrow Cells, Biology, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Cancer stem cell, acute myeloid leukemia (AML), medicine, Animals, Humans, Physical and Theoretical Chemistry, Progenitor cell, Molecular Biology, neoplastic stem cells, Organic Chemistry, Mesenchymal stem cell, Mesenchymal Stem Cells, Hematopoietic Stem Cells, microenvironment, Hematopoiesis, endothelial-to-mesenchymal transition, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Myelodysplastic Syndromes |
| الوصف: | Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell disorders that have the capacity to progress to acute myeloid leukemia (AML). Accumulating evidence suggests that the altered bone marrow (BM) microenvironment in general, and in particular the components of the stem cell niche, including mesenchymal stem cells (MSCs) and their progeny, play a pivotal role in the evolution and propagation of MDS. We here present an overview of the role of MSCs in the pathogenesis of MDS, with emphasis on cellular interactions in the BM microenvironment and related stem cell niche concepts. MSCs have potent immunomodulatory capacities and communicate with diverse immune cells, but also interact with various other cellular components of the microenvironment as well as with normal and leukemic stem and progenitor cells. Moreover, compared to normal MSCs, MSCs in MDS and AML often exhibit altered gene expression profiles, an aberrant phenotype, and abnormal functional properties. These alterations supposedly contribute to the “reprogramming” of the stem cell niche into a disease-permissive microenvironment where an altered immune system, abnormal stem cell niche interactions, and an impaired growth control lead to disease progression. The current article also reviews molecular targets that play a role in such cellular interactions and possibilities to interfere with abnormal stem cell niche interactions by using specific targeted drugs. |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d706192cb65c4c7d933931308d47ddTest https://pubmed.ncbi.nlm.nih.gov/27355944Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....43d706192cb65c4c7d933931308d47dd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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