Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy.

التفاصيل البيبلوغرافية
العنوان:	Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy.
المؤلفون:	Ollila, H.M., Sharon, E., Lin, L., Sinnott-Armstrong, N., Ambati, A., Yogeshwar, S.M., Hillary, R.P., Jolanki, O., Faraco, J., Einen, M., Luo, G., Zhang, J., Han, F., Yan, H., Dong, X.S., Li, J., Hong, S.C., Kim, T.W., Dauvilliers, Y., Barateau, L., Lammers, G.J., Fronczek, R., Mayer, G., Santamaria, J., Arnulf, I., Knudsen-Heier, S., Bredahl, MKL, Thorsby, P.M., Plazzi, G., Pizza, F., Moresco, M., Crowe, C., Van den Eeden, S.K., Lecendreux, M., Bourgin, P., Kanbayashi, T., Martínez-Orozco, F.J., Peraita-Adrados, R., Benetó, A., Montplaisir, J., Desautels, A., Huang, Y.S., Jennum, P., Nevsimalova, S., Kemlink, D., Iranzo, A., Overeem, S., Wierzbicka, A., Geisler, P., Sonka, K., Honda, M., Högl, B., Stefani, A., Coelho, F.M., Mantovani, V., Feketeova, E., Wadelius, M., Eriksson, N., Smedje, H., Hallberg, P., Hesla, P.E., Rye, D., Pelin, Z., Ferini-Strambi, L., Bassetti, C.L., Mathis, J., Khatami, R., Aran, A., Nampoothiri, S., Olsson, T., Kockum, I., Partinen, M., Perola, M., Kornum, B.R., Rueger, S., Winkelmann, J., Miyagawa, T., Toyoda, H., Khor, S.S., Shimada, M., Tokunaga, K., Rivas, M., Pritchard, J.K., Risch, N., Kutalik, Z., O'Hara, R., Hallmayer, J., Ye, C.J., Mignot, E.J.
المساهمون:	FinnGen, Als, T.D., Ziemann, A., Abbasi, A., Lehtonen, A., Lertratanakul, A., Riley-Gillis, B., Rahimov, F., Jacob, H., Waring, J., Liu, M., Smaoui, N., Popovic, R., Platt, A., Matakidou, A., Challis, B., Paul, D., Lassi, G., Tachmazidou, I., Hakanen, A., Schleutker, J., Pitkänen, N., Terho, P., Virolainen, P., Mannermaa, A., Kosma, V.M., Chen, C.Y., Runz, H., John, S., Lahdenperä, S., Loomis, S., Eaton, S., Okafo, G., Salminen-Mankonen, H., Jung, M., Lawless, N., Ding, Z., Maranville, J., Hochfeld, M., Plenge, R., Biswas, S., Kanai, M., Maasha, M., Zhou, W., Tuovila, O., Pakkanen, R., Laukkanen, J., Kuopio, T., Aittomäki, K., Mäkitie, A., Pujol, N., Laisk, T., Aalto-Setälä, K., Mäkelä, J., Hautalahti, M., Smith, S., Southerington, T., Kangasniemi, E., Palin, H., Kähönen, M., Siltanen, S., Laitinen, T., Vaura, F., Suvisaari, J., Niiranen, T., Salomaa, V., Partanen, J., Arvas, M., Ritari, J., Hyvärinen, K., Choy, D., Teng, E., Strauss, E., Chen, H., Schutzman, J., Hunkapiller, J., McCarthy, M., Bowers, N., Pendergrass, R., Lu, T., Chu, A., Kulkarni, D., Xu, F., Betts, J., Eicher, J., Gordillo, J.E., Addis, L., McCarthy, L., Mishra, R., Kumar, J., Ehm, M.G., Auro, K., Pulford, D., Pitkäranta, A., Loukola, A., Punkka, E., Linna, M.M., Carpén, O., Raivio, T.
المصدر:	Nature communications, vol. 14, no. 1, pp. 2709
سنة النشر:	2023
المجموعة:	Université de Lausanne (UNIL): Serval - Serveur académique lausannois
مصطلحات موضوعية:	Humans, Autoimmunity/genetics, Influenza, Human/epidemiology, Human/genetics, Influenza A Virus, H1N1 Subtype/genetics, Autoimmune Diseases/epidemiology, Autoimmune Diseases/genetics, Influenza Vaccines/adverse effects, Narcolepsy/chemically induced, Narcolepsy/genetics
الوصف:	Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB103:01 and DPB104:02) and discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant signals at TRA and DQB106:02 loci were found in 245 vaccination-related cases, who also shared polygenic risk. T cell receptor associations in NT1 modulated TRAJ24, TRAJ28 and TRBV4-2 chain-usage. Partitioned heritability and immune cell enrichment analyses found genetic signals to be driven by dendritic and helper T cells. Lastly comorbidity analysis using data from FinnGen, suggests shared effects between NT1 and other autoimmune diseases. NT1 genetic variants shape autoimmunity and response to environmental triggers, including influenza A infection and immunization with Pandemrix®.
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	application/pdf
اللغة:	English
تدمد:	2041-1723
العلاقة:	info:eu-repo/semantics/altIdentifier/pmid/37188663; info:eu-repo/semantics/altIdentifier/eissn/2041-1723; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_57D392F74F523; https://serval.unil.ch/notice/serval:BIB_57D392F74F52Test; urn:issn:2041-1723; https://serval.unil.ch/resource/serval:BIB_57D392F74F52.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_57D392F74F523Test
DOI:	10.1038/s41467-023-36120-z
الإتاحة:	https://doi.org/10.1038/s41467-023-36120-zTest https://serval.unil.ch/notice/serval:BIB_57D392F74F52Test https://serval.unil.ch/resource/serval:BIB_57D392F74F52.P001/REF.pdfTest http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_57D392F74F523Test
حقوق:	info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام:	edsbas.8271E80C
قاعدة البيانات:	BASE

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الوصف
تدمد:	20411723
DOI:	10.1038/s41467-023-36120-z