دورية أكاديمية
Culturomics Discloses Anti-Tubercular Enterococci Exclusive of Pulmonary Tuberculosis: A Preliminary Report
| العنوان: | Culturomics Discloses Anti-Tubercular Enterococci Exclusive of Pulmonary Tuberculosis: A Preliminary Report |
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| المؤلفون: | Fellag, Mustapha, Gouba, Nina, Bedotto, Marielle, Sakana, Moussa, Zingue, Dezemon, Tarnagda, Zekiba, Million, Matthieu, Drancourt, Michel |
| المساهمون: | Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), University Nazi Boni, Burkina Faso, Institut de Recherche en Sciences de la Santé Bobo Dioulasso (INSSA), Université Nazi Boni (Bobo-Dioulasso) (UNB), ANR-10-IAHU-0003,Méditerranée Infection,I.H.U. Méditerranée Infection(2010) |
| المصدر: | ISSN: 2076-2607 ; Microorganisms ; https://amu.hal.science/hal-03149701Test ; Microorganisms, 2020, 8 (10), ⟨10.3390/microorganisms8101544⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2020 |
| المجموعة: | Aix-Marseille Université: HAL |
| مصطلحات موضوعية: | gut microbiota, tuberculosis, Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium canettii, Enterococcus mundtii, Enterococcus casseliflavus, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Mycobacterium tuberculosis causes pulmonary tuberculosis, a deadly infection of which the clinical expression and prognosis are not fully understood at the individual level, apart from genetic susceptibility traits. We investigated whether individual gut microbiota may correlate with pulmonary tuberculosis status. Culturomics investigations of gut microbiota in two pulmonary tuberculosis patients and two controls in Burkina Faso found 60 different bacterial species in patients and 97 in controls, including 45 in common. Further analysis of the results at the individual level indicated seven bacteria, including Enterococcus mundtii and Enterococcus casseliflavus, which were exclusively cultured in controls. Blind quantitative PCR-based exploration of faeces samples in two cohorts in Burkina Faso and in France confirmed a nonsignificant association of E. mundtii and E. casseliflavus with controls. Further in vitro explorations found four E. mundtii and E. casseliflavus strains inhibiting the growth of M. tuberculosis strains representative of four different lineages as well as Mycobacterium africanum, Mycobacterium canettii, and Mycobacterium bovis, in an inoculum-dependent manner. Heat-killed E. mundtii or E. casseliflavus were ineffective. These unprecedented observations of direct interactions between gut E. mundtii and E. casseliflavus with M. tuberculosis complex mycobacteria suggest that gut microbiota may modulate the expression of pulmonary tuberculosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03149701; https://amu.hal.science/hal-03149701Test; https://amu.hal.science/hal-03149701/documentTest; https://amu.hal.science/hal-03149701/file/microorganisms-08-01544.pdfTest; PUBMEDCENTRAL: PMC7599504 |
| DOI: | 10.3390/microorganisms8101544 |
| الإتاحة: | https://doi.org/10.3390/microorganisms8101544Test https://amu.hal.science/hal-03149701Test https://amu.hal.science/hal-03149701/documentTest https://amu.hal.science/hal-03149701/file/microorganisms-08-01544.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.D32B829A |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/microorganisms8101544 |
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