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1دورية أكاديمية
المؤلفون: Wauters, Lina, Versées, Wim, Kortholt, Arjan
المصدر: Wauters , L , Versées , W & Kortholt , A 2019 , ' Roco Proteins : GTPases with a Baroque Structure and Mechanism ' , International Journal of Molecular Sciences , vol. 20 , no. 1 , ijms20010147 . https://doi.org/10.3390/ijms20010147Test
مصطلحات موضوعية: Parkinson's disease, leucine-rich repeat kinase 2, Roco proteins, unconventional G-protein, GTPase mechanism, LEUCINE-RICH-REPEAT, ENVIRONMENTAL RISK-FACTORS, PARKINSONS-DISEASE, GTP-BINDING, LRRK2 GTPASE, DAP-KINASE, LEUCINE-RICH-REPEAT-KINASE-2 LRRK2, SIGNAL-TRANSDUCTION, GENE LRRK2, G-DOMAIN
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.3390/ijms20010147Test
https://hdl.handle.net/11370/5630914a-1cdd-4fa4-a55a-8539f2592c17Test
https://research.rug.nl/en/publications/5630914a-1cdd-4fa4-a55a-8539f2592c17Test
https://pure.rug.nl/ws/files/73992222/ijms_20_00147.pdfTest -
2دورية أكاديمية
المؤلفون: Deyaert, Egon, Leemans, Margaux, Singh, Ranjan Kumar, Gallardo, Rodrigo, Steyaert, Jan, Kortholt, Arjan, Lauer, Janelle, Versées, Wim
المصدر: Deyaert , E , Leemans , M , Singh , R K , Gallardo , R , Steyaert , J , Kortholt , A , Lauer , J & Versées , W 2019 , ' Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein ' , Biochemical Journal , vol. 476 , no. 1 , pp. 51-66 . https://doi.org/10.1042/BCJ20180803Test
مصطلحات موضوعية: structure, conformational dynamics, Roco proteins, Chlorobium tepidum, LRKK2, DISEASE-ASSOCIATED MUTATIONS, GTP-BINDING, LRRK2, DOMAIN, GENE, EVOLUTIONARY, REVEALS, GAPS, GEFS, RAS
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1042/BCJ20180803Test
https://hdl.handle.net/11370/9657fbae-4af3-4c34-adfd-95ad96c41fa1Test
https://research.rug.nl/en/publications/9657fbae-4af3-4c34-adfd-95ad96c41fa1Test
https://pure.rug.nl/ws/files/73865954/51.full.pdfTest -
3دورية أكاديمية
المؤلفون: Athanasopoulos, Panagiotis S, Heumann, Rolf, Kortholt, Arjan
المصدر: Athanasopoulos , P S , Heumann , R & Kortholt , A 2018 , ' The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2 ' , Biological Chemistry , vol. 399 , no. 7 , pp. 643-647 . https://doi.org/10.1515/hsz-2017-0332Test
مصطلحات موضوعية: GTPase, kinase, neuronal degeneration, Parkinson's disease, phosphatases, DISEASE-ASSOCIATED MUTATIONS, SYNAPTIC VESICLE TRAFFICKING, REPEAT KINASE 2, PARKINSONS-DISEASE, GTP-BINDING, CYTOPLASMIC LOCALIZATION, PHOSPHORYLATION, PENETRANCE, PHENOTYPE, PROTEINS
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1515/hsz-2017-0332Test
https://hdl.handle.net/11370/6482c199-7fd5-45c1-9c98-8fb4b643e7deTest
https://research.rug.nl/en/publications/6482c199-7fd5-45c1-9c98-8fb4b643e7deTest
https://pure.rug.nl/ws/files/61955616/_Biological_Chemistry_The_role_of_auto_phosphorylation_in_the_complex_activation_mechanism_of_LRRK2_1_.pdfTest -
4دورية أكاديمية
المؤلفون: Deyaert, Egon, Wauters, Lina, Guaitoli, Giambattista, Konijnenberg, Albert, Leemans, Margaux, Terheyden, Susanne, Petrovic, Arsen, Gallardo, Rodrigo, Nederveen-Schippers, Laura M, Athanasopoulos, Panagiotis S, Pots, Henderikus, Van Haastert, Peter J M, Sobott, Frank, Gloeckner, Christian Johannes, Efremov, Rouslan, Kortholt, Arjan, Versées, Wim
المصدر: Deyaert , E , Wauters , L , Guaitoli , G , Konijnenberg , A , Leemans , M , Terheyden , S , Petrovic , A , Gallardo , R , Nederveen-Schippers , L M , Athanasopoulos , P S , Pots , H , Van Haastert , P J M , Sobott , F , Gloeckner , C J , Efremov , R , Kortholt , A & Versées , W 2017 , ' A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover ' , Nature Communications , vol. 8 , ....
مصطلحات موضوعية: Parkinson's disease, LRRK2, protein conformation, transition, GTP-binding
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1038/s41467-017-01103-4Test
https://hdl.handle.net/11370/089faf34-0b0d-403a-a363-f004d4313ffaTest
https://research.rug.nl/en/publications/089faf34-0b0d-403a-a363-f004d4313ffaTest
https://pure.rug.nl/ws/files/49388691/s41467_017_01103_4.pdfTest -
5دورية أكاديمية
المصدر: Terheyden , S , Nederveen-Schippers , L M & Kortholt , A 2016 , ' The unconventional G-protein cycle of LRRK2 and Roco proteins ' , Biochemical Society Transactions , vol. 44 , no. 6 , pp. 1611-1616 . https://doi.org/10.1042/BST20160224Test
مصطلحات موضوعية: REPEAT KINASE 2, DISEASE-ASSOCIATED MUTATIONS, FAMILIAL PARKINSONS-DISEASE, GTP-BINDING, NEURONAL TOXICITY, DOMAIN, MUTANT, LEUCINE-RICH-REPEAT-KINASE-2, HYDROLYSIS, REVEALS
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1042/BST20160224Test
https://hdl.handle.net/11370/44b224c7-196d-402d-a0df-f42faaf3a727Test
https://research.rug.nl/en/publications/44b224c7-196d-402d-a0df-f42faaf3a727Test
https://pure.rug.nl/ws/files/135005902/The_unconventional_G_protein_cycle_of_LRRK2_and_Roco_proteins.pdfTest -
6دورية أكاديمية
المؤلفون: Rosenbusch, Katharina E., Kortholt, Arjan
المصدر: Rosenbusch , K E & Kortholt , A 2016 , ' Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease ' , Parkinsons disease , vol. 2016 , ID 7351985 . https://doi.org/10.1155/2016/7351985Test
مصطلحات موضوعية: KINASE 2 LRRK2, GTP-BINDING, MITOCHONDRIAL DEPOLARIZATION, NEURONAL TOXICITY, DOMAIN, PROTEIN, MUTATIONS, INHIBITORS, AUTOPHAGY, AUTOPHOSPHORYLATION
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1155/2016/7351985Test
https://hdl.handle.net/11370/4c8a323a-5680-48d7-9cc2-3889d2cc967dTest
https://research.rug.nl/en/publications/4c8a323a-5680-48d7-9cc2-3889d2cc967dTest
https://pure.rug.nl/ws/files/56014082/7351985.pdfTest -
7دورية أكاديمية
المؤلفون: Terheyden, Susanne, Ho, Franz Y., Gilsbach, Bernd K., Wittinghofer, Alfred, Kortholt, Arjan
المصدر: Terheyden , S , Ho , F Y , Gilsbach , B K , Wittinghofer , A & Kortholt , A 2015 , ' Revisiting the Roco G-protein cycle ' , Biochemical Journal , vol. 465 , no. 1 , pp. 139-147 . https://doi.org/10.1042/BJ20141095Test
مصطلحات موضوعية: dimerization, GAD, guanosine-5 '-triphosphatase (GTPase), leucine-rich-repeat kinase 2 (LRRK2), Parkinson's disease, DISEASE-ASSOCIATED MUTATIONS, FAMILIAL PARKINSONS-DISEASE, KINASE-ACTIVITY, LEUCINE-RICH-REPEAT-KINASE-2 LRRK2, GTP-BINDING, DOMAIN, MECHANISM, INSIGHTS, GENE
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1042/BJ20141095Test
https://hdl.handle.net/11370/de0ad625-c8e4-494b-94c4-10924f96eb88Test
https://research.rug.nl/en/publications/de0ad625-c8e4-494b-94c4-10924f96eb88Test
https://pure.rug.nl/ws/files/85062820/Revisiting_the_Roco_G_protein_cycle.pdfTest -
8دورية أكاديمية
المؤلفون: Kortholt, Arjan, van Egmond, Wouter N., Plak, Katarzyna, Bosgraaf, Leonard, Keizer-Gunnink, Ineke, van Haastert, Peter J. M.
المصدر: Kortholt , A , van Egmond , W N , Plak , K , Bosgraaf , L , Keizer-Gunnink , I & van Haastert , P J M 2012 , ' Multiple Regulatory Mechanisms for the Dictyostelium Roco Protein GbpC ' , The Journal of Biological Chemistry , vol. 287 , no. 4 , pp. 2749-2758 . https://doi.org/10.1074/jbc.M111.315739Test
مصطلحات موضوعية: DISEASE-ASSOCIATED MUTATIONS, PARKINSONS-DISEASE, KINASE-ACTIVITY, MYOSIN PHOSPHORYLATION, SIGNALING PATHWAY, GTP-BINDING, GRAM DOMAIN, LRRK2, CHEMOTAXIS, CGMP
الإتاحة: https://doi.org/10.1074/jbc.M111.315739Test
https://hdl.handle.net/11370/f9bd9742-5580-4da4-af28-f5626b4ea22bTest
https://research.rug.nl/en/publications/f9bd9742-5580-4da4-af28-f5626b4ea22bTest
