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المساهمون: Imperial College Trust, Imperial College Healthcare NHS Trust, Imperial College Healthcare NHS Trust - CLRN Funding, Imperial College Healthcare NHS Trust- BRC Funding

المصدر: Blood

مصطلحات موضوعية: 0301 basic medicine, Male, Models, Molecular, Clinical Trials and Observations, Activin Receptors, Type II, DNA Mutational Analysis, ALK1, Biochemistry, Cohort Studies, 0302 clinical medicine, Genotype, Growth Differentiation Factor 2, 1102 Cardiorespiratory Medicine and Haematology, Smad4 Protein, Massive parallel sequencing, medicine.diagnostic_test, Endoglin, GENETIC-VARIATION, High-Throughput Nucleotide Sequencing, TGF-BETA, Hematology, Genomics, GENOTYPE, PREVALENCE, Phenotype, Medical genetics, ARTERIOVENOUS-MALFORMATIONS, Female, Telangiectasia, Hereditary Hemorrhagic, Life Sciences & Biomedicine, medicine.medical_specialty, Heterozygote, Immunology, Context (language use), Computational biology, Biology, HHT, 03 medical and health sciences, Human Phenotype Ontology, Genetic variation, medicine, Humans, Genetic Predisposition to Disease, Genetic Testing, Genetic Association Studies, Genetic testing, Retrospective Studies, Science & Technology, IDENTIFICATION, 1103 Clinical Sciences, Cell Biology, Sequence Analysis, DNA, 030104 developmental biology, Mutation, 1114 Paediatrics and Reproductive Medicine, JUVENILE POLYPOSIS, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67c88ac838f58210b09668375add670Test
https://europepmc.org/articles/PMC7717479Test/

4

A signaling crosstalk between BMP9 and HGF/c-met regulates mouse adult liver progenitor cell survival

المؤلفون: Nerea Lazcanoiturburu, Isabel Fabregat, Laura Almalé, María García-Álvaro, Peter ten Dijke, Rebeca Méndez, Aránzazu Sánchez, Annalisa Addante, C. Roncero, Blanca Herrera

المصدر: Cells, 9(3). MDPI
Dipòsit Digital de la UB
Universidad de Barcelona
Cells, Vol 9, Iss 3, p 752 (2020)
E-Prints Complutense. Archivo Institucional de la UCM
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Cells
Volume 9
Issue 3

مصطلحات موضوعية: 0301 basic medicine, Aging, Activin Receptors, Type II, SMAD1, Smad Proteins, Apoptosis, SMAD, ALK1, p38 Mitogen-Activated Protein Kinases, chemistry.chemical_compound, Mice, 0302 clinical medicine, Growth Differentiation Factor 2, HGF, lcsh:QH301-705.5, Biología molecular, Hepatocyte Growth Factor, Stem Cells, Malalties del fetge, apoptosis, General Medicine, Proto-Oncogene Proteins c-met, Liver regeneration, 3. Good health, Cell biology, Crosstalk (biology), Liver, 030220 oncology & carcinogenesis, p38MAPK, Hepatocyte growth factor, Mothers against decapentaplegic, medicine.drug, Signal Transduction, Bioquímica, C-Met, Cell Survival, Biology, signaling crosstalk, Bone morphogenetic protein, BMP9, Article, Cell Line, 03 medical and health sciences, hepatic oval cell, medicine, Animals, Humans, Progenitor cell, Liver diseases, Apoptosi, Enzyme Activation, 030104 developmental biology, chemistry, lcsh:Biology (General)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3aef51c14ed766ce0546c4c25e2b10Test
http://hdl.handle.net/1887/3182615Test

5

Metformin inhibits ALK1-mediated angiogenesis via activation of AMPK

المؤلفون: Hui Lin, Shanshan Jiang, Ying Ying, Ye-Guang Chen, Demetrios G. Vavvas, Takashi Ueta, Yuanyuan Wang, Zhijun Luo, Rong Wen

المصدر: Oncotarget

مصطلحات موضوعية: 0301 basic medicine, AMPK, Smad5 Protein, Angiogenesis, Activin Receptors, Type II, Angiogenesis Inhibitors, ALK1, Smad1 Protein, Neovascularization, 03 medical and health sciences, Mice, Downregulation and upregulation, medicine, Growth Differentiation Factor 2, Human Umbilical Vein Endothelial Cells, Animals, Humans, Pharmaceutical sciences, Phosphorylation, Tube formation, business.industry, Adenylate Kinase, tumor angiogenesis, Xenograft Model Antitumor Assays, Choroidal Neovascularization, Metformin, 3. Good health, Enzyme Activation, Gene Expression Regulation, Neoplastic, Growth Differentiation Factors, 030104 developmental biology, Choroidal neovascularization, Pyrimidines, Oncology, Immunology, Cancer research, Quinolines, Pyrazoles, medicine.symptom, business, medicine.drug, Research Paper

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e0f226cb6b371eea9896eb0f5b91cfTest
http://europepmc.org/articles/PMC5464828Test

6

Dual targeting of vascular endothelial growth factor and bone morphogenetic protein‐9/10 impairs tumor growth through inhibition of angiogenesis

المؤلفون: Yuichi Akatsu, Tetsuro Watabe, Kazuki Takahashi, Yasuhiro Yoshimatsu, Kohei Miyazono, Akihiro Katsura, Taishi Tomizawa

المصدر: Cancer Science

مصطلحات موضوعية: 0301 basic medicine, Vascular Endothelial Growth Factor A, Cancer Research, Angiogenesis, Activin Receptors, Type II, Recombinant Fusion Proteins, Mice, Nude, ALK1, Vascular endothelial growth inhibitor, Bone morphogenetic protein, 03 medical and health sciences, chemistry.chemical_compound, angiogenesis, Mice, 0302 clinical medicine, Pancreatic cancer, Report, Antineoplastic Combined Chemotherapy Protocols, medicine, Growth Differentiation Factor 2, Animals, Humans, Receptor, Cell Proliferation, Mice, Inbred BALB C, Vascular Endothelial Growth Factor Receptor-1, vascular endothelial growth factor, Neovascularization, Pathologic, business.industry, BMP‐9/10, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, Blockade, Immunoglobulin Fc Fragments, Vascular endothelial growth factor, Fc‐chimera, Pancreatic Neoplasms, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, Immunology, Bone Morphogenetic Proteins, Cancer research, Female, Decoy, business, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8161ca21d840639a2ec9c82867e3f1Test
http://europepmc.org/articles/PMC5276835Test

7

Compound genetically engineered mouse models of cancer reveal dual targeting of ALK1 and endoglin as a synergistic opportunity to impinge on angiogenic TGF-β signaling

المؤلفون: Jonas Sjölund, Se-Jin Lee, Sara I. Cunha, Eliane Cortez, Kristian Pietras, Matteo Bocci, Nikolas M. Eleftheriou

المصدر: Oncotarget

مصطلحات موضوعية: 0301 basic medicine, Angiogenesis, Activin Receptors, Type II, medicine.medical_treatment, GDF2, Mice, Transgenic, ALK1, BMP9, Targeted therapy, angiogenesis, 03 medical and health sciences, 0302 clinical medicine, Transforming Growth Factor beta, Growth Differentiation Factor 2, medicine, Animals, Humans, Receptor, Mice, Knockout, endoglin, Neovascularization, Pathologic, business.industry, Gene Expression Profiling, Cancer, Endoglin, targeted therapy, medicine.disease, Primary tumor, Phenotype, Tumor Burden, 3. Good health, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Pancreatic Neoplasms, Neuroendocrine Tumors, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Immunology, Cancer research, business, Activin Receptors, Type I, Research Paper, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171e57a162dbd6795e81db629253431fTest
https://doi.org/10.18632/oncotarget.12604Test

8

Regulation of the ALK1 ligands, BMP9 and BMP10

المؤلفون: Wei Li, Richard M. Salmon, Nicholas W. Morrell, He Jiang

المساهمون: Li, Wei [0000-0002-1924-3120], Morrell, Nicholas [0000-0001-5700-9792], Apollo - University of Cambridge Repository

المصدر: Biochemical Society Transactions. 44:1135-1141

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Angiogenesis, Activin Receptors, Type II, Biology, bone morphogenetic protein 9 (BMP9), Ligands, Bone morphogenetic protein, Models, Biological, Biochemistry, 03 medical and health sciences, activin receptor-like kinase 1 (ALK1), Neoplasms, Internal medicine, Growth Differentiation Factor 2, medicine, Dalantercept, Animals, Humans, Receptor, BMP receptor type II (BMPR-II), Kinase, bone morphogenetic protein 10 (BMP10), Bone morphogenetic protein 10, BMPR2, Growth Differentiation Factors, 030104 developmental biology, Endocrinology, Bone Morphogenetic Proteins, endothelial cell, Cancer research, Endothelium, Vascular, Signal transduction, signal transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff43c0660e851ee31237d0e521507e1eTest
https://doi.org/10.1042/bst20160083Test

9

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage

المؤلفون: Karen M. Lyons, Peyman Razavi, Joshua Sadik, Jongseung Baek, Noah Lopez, Hyelim Chun, Weiguang Wang, Anna Shirazyan

المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 31
Proceedings of the National Academy of Sciences of the United States of America

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d475dcf885b712e0006f3884d4e290fTest
https://escholarship.org/uc/item/2z80b5chTest

10

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis

المؤلفون: Kerr, G, Sheldon, H, Chaikuad, A, Alfano, I, von Delft, F, Bullock, A, Harris, A

المصدر: Angiogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bff0fbc56ae735f7f323b50f349780f0Test
http://europepmc.org/articles/PMC4363482Test

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