التفاصيل البيبلوغرافية
| العنوان: |
Do flavan-3-ols from green tea reach the human brain? |
| المؤلفون: |
Zini, Andrea, Rio, Daniele Del, Stewart, Amanda J., Mandrioli, Jessica, Merelli, Elisa, Sola, Patrizia, Nichelli, Paolo, Serafini, Mauro, Brighenti, Furio, Edwards, Christine A., Crozier, Alan |
| المصدر: |
Nutritional Neuroscience; Feb2006, Vol. 9 Issue 1/2, p57-61, 5p, 2 Charts, 1 Graph |
| مصطلحات موضوعية: |
BRAIN, GREEN tea, FLAVINS, HUMAN beings, CEREBROSPINAL fluid, CEREBRAL circulation |
| مستخلص: |
Following acute ingestion of green tea by six human subjects, HPLC-MS 2 analysis revealed that flavan-3-ol methyl, glucuronide and sulfate metabolites appeared in the bloodstream but did not pass through the blood–cerebrospinal fluid barrier. These observations emphasize the discrepancies between in vitro and in vivo evidence on the neuroprotective role of these compounds. If, as has been proposed, green tea exerts neuroprotective effects, this finding indicates that the active components are not flavan-3-ols or their metabolites. Alternatively, a systemic action may be hypothesised whereby dietary flavan-3-ols up-regulate antioxidant defences and/or reduce inflammation, the benefit of which may be effective throughout the body. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
