Učinak hipertireoze i antitiroidne terapije na koštanu gustoću - patofiziološki mehanizmi te kliničko značenje
| العنوان: | Učinak hipertireoze i antitiroidne terapije na koštanu gustoću - patofiziološki mehanizmi te kliničko značenje |
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| المؤلفون: | Mudri, Dunja, Kizivat, Tomislav, Smolić, Martina, Mihaljević, Ivica, Smolić, Robert, Raguž Lučić, Nikola, Bilić-Ćurčić, Ines |
| المصدر: | Acta clinica Croatica Volume 61. Issue 3 |
| بيانات النشر: | Sestre Milosrdnice University hospital and Institute of Clinical Medical Research, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Graves’ disease, Bone Mineral Density, Wnt Signaling Pathway, Sclerostin, Dickkopf 1, Gravesova bolest, koštana gustoća, Wnt signalni put, sklerostin, dickkopf 1 |
| الوصف: | Graves’ disease is an autoimmune disease characterized by excessive thyroid hormone production. One of the consequences of that state can be a decrease in bone mineral density (BMD). Graves’ disease is often treated with antithyroid drugs (ATD) as first line therapy, which can lead to disease remission. Moreover, recent data show that improvement in BMD can be expected. However, vitamin D deficiency can coexist along with Graves’ disease, which is also involved in the process of bone remodeling. It is still not known whether lower values of vitamin D can contribute to onset of Graves’ disease and if its supplementation might be helpful in therapy for hyperthyroidism. In the past couple of decades, osteopenia and osteoporosis have become a major health burden not only in post-menopausal women but also as a result of other diseases, leading to extensive research into various pathophysiological mechanisms responsible for bone remodeling. The Wnt (wingless integrated) signaling pathway is a very important factor in bone homeostasis, especially the canonical pathway. Present data indicate that stimulation of the Wnt pathway leads to bone mass increase and, in contrast, its inhibition leads to bone mass decrease. Hence, inhibitors of the canonical Wnt pathway became the focus of interest, in particular sclerostin and dickkopf 1 (DKK1). Hyperthyroidism and osteopenia/osteoporosis are quite common today and can coexist together or as separate entities. In this article, we aimed to give an overview of possible associations and potential mutual pathophysiological mechanisms. Gravesova bolest je autoimuna bolest karakterizirana prevelikom proizvodnjom hormona štitnjače. Jedna od posljedica toga stanja može biti sniženje mineralne gustoće kosti. Liječi se antitireoidnim lijekovima kao prvim izborom čime se može postići remisija bolesti. Postizanjem remisije, može se očekivati i poboljšanje mineralne gustoće kosti. No, uz Gravesovu bolest, može postojati i snižena vrijednost vitamina D koji je također važana za procese pregradnje kosti. Još je uvijek otvoreno pitanje mou li snižene vrijednosti vitamina D pridonijeti nastanku Gravesove bolesti i da li bi njegova supstitucija mogla pomoći u liječenju hipertireoze. Kako je smanjena mineralna gustoća kosti danas rasprostranjena širom svijeta, u prošlim desetljećima počeo se istraživati Wnt put. Ovaj put vrlo je važan za homeostazu kosti, osobito njegov dio koji se naziva kanonički put u kojem sudjeluju i sklerostin i dickkopf 1 kao inhibitori. Svi spomenuti čimbenici, odnosno stanja, danas su učestala i mogu postojati zajedno i odvojeno. Ovim člankom pokušali smo dati pregled moguće veze između njih. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1333-9451 0353-9466 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=od_______951::d9d9e089cd4efc4d421357eec9eaabc8Test https://hrcak.srce.hr/296156Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.od.......951..d9d9e089cd4efc4d421357eec9eaabc8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13339451 03539466 |
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