التفاصيل البيبلوغرافية
| العنوان: |
Epigenome Regulation by Dynamic Nucleosome Unwrapping. |
| المؤلفون: |
Brahma, Sandipan1 (AUTHOR), Henikoff, Steven1,2 (AUTHOR) steveh@fhcrc.org |
| المصدر: |
Trends in Biochemical Sciences. Jan2020, Vol. 45 Issue 1, p13-26. 14p. |
| مصطلحات موضوعية: |
*TRANSCRIPTION factors, *DNA-protein interactions, *HISTONES, *GENETIC regulation, *CHROMATIN, *EPIGENOMICS, *GOVERNMENT regulation |
| مستخلص: |
Gene regulation in eukaryotes requires the controlled access of sequence-specific transcription factors (TFs) to their sites in a chromatin landscape dominated by nucleosomes. Nucleosomes are refractory to TF binding, and often must be removed from regulatory regions. Recent genomic studies together with in vitro measurements suggest that the nucleosome barrier to TF binding is modulated by dynamic nucleosome unwrapping governed by ATP-dependent chromatin remodelers. Genome-wide occupancy and the regulation of subnucleosomal intermediates have gained recent attention with the application of high-resolution approaches for precision mapping of protein–DNA interactions. We summarize here recent findings on nucleosome substructures and TF binding dynamics, and highlight how unwrapped nucleosomal intermediates provide a novel signature of active chromatin. High-resolution mapping uncovers dynamically unwrapped nucleosomes at regulatory regions. Dynamic nucleosome unwrapping is a general feature of transcriptional regulation. ATP-dependent chromatin remodelers catalyze nucleosome unwrapping that may facilitate transcription factor binding. Unwrapped nucleosomal intermediates provide a novel physical signature of active chromatin. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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