التفاصيل البيبلوغرافية
| العنوان: |
Distribution of autoantibodies to glutamic acid decarboxylase across the spectrum of diabetes mellitus seen in South Africa. |
| المؤلفون: |
Panz, V. R.1, Kalk, W. J.2, Zouvanis, M.1, Joffe, B. I.1 |
| المصدر: |
Diabetic Medicine. Jul2000, Vol. 17 Issue 7, p524-527. 4p. |
| مصطلحات موضوعية: |
*GLUTAMATE decarboxylase, *IMMUNOGLOBULINS, *DIABETES, *TYPE 2 diabetes |
| مصطلحات جغرافية: |
SOUTH Africa |
| مستخلص: |
SUMMARY Aims This study investigated the association between glutamic acid decarb- oxylase antibodies (GAD-AB) and Type 1, Type 2, pancreatic and lipoatrophic diabetes mellitus (DM) in South African patients. Methods Four groups were selected: group A, 100 Black Type 1 DM patients (age at onset < 35 years, body mass index (BMI) < 27 kg/m2 and insulin dependent within 1 year of presentation); group B, 80 Black Type 2 DM patients (age at onset > 35 years, BMI > 27 kg/m2 and controlled on oral hypoglycaemic agents for at least 1 year after presentation); group C, 10 patients of varying ethnicity with DM or impaired glucose tolerance secondary to chronic pancreatitis; group D, five patients of varying ethnicity with DM associated with total lipodystrophy. Fifty healthy Black control subjects were also studied (group E). Serum GAD-AB and random C-peptide levels were measured by radioimmunoassay. Results Mean C-peptide concentration was significantly lower in Type 1 DM patients than Type 2 DM patients (P < 0.00001). Forty-four patients with Type 1 DM were GAD-AB-positive compared to two patients with Type 2 DM. Two control subjects were also GAD-AB-positive. No patient in the other groups had a titre > 1 U/ml. Type 1 DM patients who were GAD-AB-positive did not differ from those who were GAD-AB-negative for age at onset, duration of DM or C-peptide concentrations. Conclusions Auto-immune beta-cell destruction has an important role in the pathogenesis of Type 1 DM amongst African patients. However, Type 2 African DM patients and other diabetes subtypes are largely GAD-AB-negative. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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