دورية أكاديمية
Proglucagon peptide secretion profiles in type 2 diabetes before and after bariatric surgery: 1-year prospective study
| العنوان: | Proglucagon peptide secretion profiles in type 2 diabetes before and after bariatric surgery: 1-year prospective study |
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| المؤلفون: | Alexiadou, K, Cuenco, J, Howard, J, Albrechtsen, NJW, Ilesanmi, I, Kamocka, A, Tharakan, G, Behary, P, Bech, PR, Ahmed, AR, Purkayastha, S, Wheller, R, Fleuret, M, Holst, JJ, Bloom, SR, Khoo, B, Tan, TM-M |
| المساهمون: | National Institute for Health Research |
| المصدر: | 10 ; 1 |
| بيانات النشر: | BMJ Publishing Group |
| سنة النشر: | 2020 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, glucagon, glucagon-like peptide-1 (GLP-1), obesity, bariatric surgery, Y GASTRIC BYPASS, BETA-CELL FUNCTION, GLUCAGON-LIKE PEPTIDE-1, WEIGHT-LOSS, RECEPTOR ANTAGONIST, GLUCOSE-TOLERANCE, OXYNTOMODULIN, GLICENTIN, HORMONES, GLP-1, 1103 Clinical Sciences |
| الوصف: | Introduction Hyperglucagonemia is a key pathophysiological driver of type 2 diabetes. Although Roux-en-Y gastric bypass (RYGB) is a highly effective treatment for diabetes, it is presently unclear how surgery alters glucagon physiology. The aim of this study was to characterize the behavior of proglucagon-derived peptide (glucagon, glucagon-like peptide-1 (GLP-1), oxyntomodulin, glicentin) secretion after RYGB surgery. Research design and methods Prospective study of 19 patients with obesity and pre-diabetes/diabetes undergoing RYGB. We assessed the glucose, insulin, GLP-1, glucose-dependent insulinotropic peptide (GIP), oxyntomodulin, glicentin and glucagon responses to a mixed-meal test (MMT) before and 1, 3 and 12 months after surgery. Glucagon was measured using a Mercodia glucagon ELISA using the ‘Alternative’ improved specificity protocol, which was validated against a reference liquid chromatography combined with mass spectrometry method. Results After RYGB, there were early improvements in fasting glucose and glucose tolerance and the insulin response to MMT was accelerated and amplified, in parallel to significant increases in postprandial GLP-1, oxyntomodulin and glicentin secretion. There was a significant decrease in fasting glucagon levels at the later time points of 3 and 12 months after surgery. Glucagon was secreted in response to the MMT preoperatively and postoperatively in all patients and there was no significant change in this postprandial secretion. There was no significant change in GIP secretion. Conclusions There is a clear difference in the dynamics of secretion of proglucagon peptides after RYGB. The reduction in fasting glucagon secretion may be one of the mechanisms driving later improvements in glycemia after RYGB. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2052-4897 |
| العلاقة: | BMJ Open Diabetes Research and Care; http://hdl.handle.net/10044/1/82366Test; EME/13/121/07 |
| DOI: | 10.1136/bmjdrc-2019-001076 |
| الإتاحة: | https://doi.org/10.1136/bmjdrc-2019-001076Test http://hdl.handle.net/10044/1/82366Test |
| حقوق: | © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0Test/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0Test/. ; http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.3E9679D6 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20524897 |
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| DOI: | 10.1136/bmjdrc-2019-001076 |