المؤلفون: Shweta Urva, Joshua A Levine, Karen Schneck, Cheng Cai Tang

مصطلحات موضوعية: Biochemistry, Genetics, Physiology, Pharmacology, Science Policy, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, type 2 diabetes, glycated hemoglobin, body weight, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, tirzepatide

العلاقة: https://figshare.com/articles/journal_contribution/Model-based_simulation_of_glycaemic_effect_and_body_weight_loss_when_switching_from_semaglutide_or_dulaglutide_to_once_weekly_tirzepatide/25289189Test

الإتاحة: https://doi.org/10.6084/m9.figshare.25289189.v1Test
https://figshare.com/articles/journal_contribution/Model-based_simulation_of_glycaemic_effect_and_body_weight_loss_when_switching_from_semaglutide_or_dulaglutide_to_once_weekly_tirzepatide/25289189Test

المؤلفون: Shweta Urva, Emily C Beebe, Michael A. Nauck, Charles Benson, Xuewei Cui, Tamer Coskun, Corina Loghin, Libbey S. O’Farrell, Daniel A. Briere, Axel Haupt

المصدر: Diabetes, Obesity and Metabolism. 22:1886-1891

مصطلحات موضوعية: Agonist, endocrine system, medicine.medical_specialty, Gastric emptying, medicine.drug_class, business.industry, Endocrinology, Diabetes and Metabolism, Semaglutide, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Glucagon-like peptide-1, Acetaminophen, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Internal Medicine, medicine, Dulaglutide, business, Receptor, Glucagon-like peptide 1 receptor, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::98a07224445c496000bf7c6feab8566eTest
https://doi.org/10.1111/dom.14110Test

المؤلفون: Shweta Urva, Julie S. Moyers, Krister Bokvist, Kyle W. Sloop, Jorge Alsina-Fernandez, William C. Roell, Charles Benson, Uma Kuchibhotla, David A. D'Alessio, Corina Loghin, Xuewei Cui, Tamer Coskun, Over Cabrera, Daniel A. Briere, Ruth E. Gimeno, Axel Haupt

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 18, Iss, Pp 3-14 (2018)

مصطلحات موضوعية: 0301 basic medicine, ipGTT, Intraperitoneal glucose tolerance test, LY3298176, ADA, Antidrug antibodies, Receptor agonist activity, Pharmacology, 0302 clinical medicine, Glucagon-Like Peptide 1, Medicine, OGTT, Oral glucose tolerance test, Receptor, T2DM, Type 2 diabetes mellitus, CNS, Central nervous system, ECG, Electrocardiogram, SMBG, Self-monitored blood glucose, Glucagon-like peptide-1, SAD, Single-ascending dose, LY, LY3298176, Original Article, medicine.drug, Agonist, POC, Proof-of-concept, lcsh:Internal medicine, Glucose-dependent insulinotropic polypeptide, medicine.drug_class, Incretin, 030209 endocrinology & metabolism, GLP-1 RA, Glucagon-like peptide-1 receptor agonist, Incretins, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Metabolic Diseases, PL, PPlacebo, Diabetes mellitus, Type 2 diabetes mellitus, Humans, DU, Dulaglutide, Obesity, GIP, Glucose-dependent insulinotropic polypeptide, lcsh:RC31-1245, Molecular Biology, MAD, Multiple-ascending dose, Glucagon-like peptide 1 receptor, business.industry, CI, Confidence interval, Cell Biology, medicine.disease, DIO, Diet-induced obesity, 030104 developmental biology, HS, Healthy subjects, Diabetes Mellitus, Type 2, MMRM, Mixed model for repeated measures, Dulaglutide, business, LSM, Least square mean

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ca485dc3a86e98e8a5c2fbb364cd27Test
http://europepmc.org/articles/PMC6308032Test

المؤلفون: Francis S. Willard, Mette M. Rosenkilde, David B. Wainscott, Guemalli R. Cardona, Shweta Urva, Jens J. Holst, Matthew P. Coghlan, Todd M. Suter, Megan E. Capozzi, Kyle W. Sloop, Jonathan D. Douros, Cynthia Stutsman, David A. D'Alessio, Aaron D. Showalter, Jonathan E. Campbell, Maria Buur Nordskov Gabe, Wijnand J.C. van der Velden, Paul J. Emmerson

المصدر: JCI Insight, Vol 5, Iss 17 (2020)
Willard, F S, Douros, J D, Gabe, M, Showalter, A D, Wainscott, D B, Suter, T M, Capozzi, M E, van der Velden, W J C, Stutsman, C, Cardona, G R, Urva, S, Emmerson, P J, Holst, J J, D'Alessio, D A, Coghlan, M P, Rosenkilde, M M, Campbell, J E & Sloop, K W 2020, ' Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist ', JCI insight, vol. 5, no. 17, 140532 . https://doi.org/10.1172/jci.insight.140532Test
JCI Insight

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Pharmacology, ACTIVATION, Mice, 0302 clinical medicine, Functional selectivity, Insulin, Receptor, PHARMACOLOGY, AFFINITY, Mice, Knockout, geography.geographical_feature_category, GLUCAGON-LIKE PEPTIDE-1, Chemistry, Diabetes, General Medicine, Islet, beta-Arrestin 1, 030220 oncology & carcinogenesis, Medicine, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, Research Article, Agonist, endocrine system, medicine.drug_class, DEPENDENT INSULINOTROPIC POLYPEPTIDE, Gastric Inhibitory Polypeptide, Therapeutics, Glucagon-Like Peptide-1 Receptor, Receptors, Gastrointestinal Hormone, Islets of Langerhans, 03 medical and health sciences, Diabetes mellitus, medicine, SERUM-PROTEIN BINDING, Animals, Hypoglycemic Agents, Glucagon-like peptide 1 receptor, geography, DULAGLUTIDE, IN-VITRO, medicine.disease, 030104 developmental biology, Mechanism of action, Metabolic control analysis, INHIBITORS, SEMAGLUTIDE

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624e5796daeef879f0b6faed814fb99cTest
https://doaj.org/article/03002ae150b14972b6d0c404574ecbbdTest