التفاصيل البيبلوغرافية
| العنوان: |
Beta-blockers in hypertensive non-insulin-dependent diabetics: Comparison between penbutolol and propranolol on metabolic control and response to insulin-induced hypoglycemia. |
| المؤلفون: |
Marengo, Claudio, Marena, Saverio, Renzetti, Anna, Mossino, Massimo, Pagano, Gianfranco |
| المصدر: |
Acta Diabetologica Latina; 1988, Vol. 25 Issue 2, p141-148, 8p |
| مستخلص: |
In a single blind randomized study the effects of a 4-week administration of propranolol (160 mg/day) and penbutolol (40 mg/day) on metabolic control and insulin-induced hypoglycemia were tested in 8 non-insulin-dependent diabetics with diastolic blood pressure between 95 and 110 mmHg. The recovery from hypoglycemia was not delayed by either drug; hypoglycemic nadir and Conard's K did not change significantly. Symptoms of hypoglycemia were inhibited to a lesser extent and pulse rate decrease was lower after penbutolol vs baseline (65±2.4 vs 77±2.4 beats/min, p<0.01) than after propranolol vs baseline (61±1.06 vs 77±2.4 beats/min p<0.001). Both drugs produced similar and significant effects on blood pressure both systolic and diastolic. There were no significant effects on fasting plasma glucose concentration, HbA, IRI, urinary C-peptide, triglycerides, total and HDL cholesterol and FFA. IRG decreased after penbutolol vs baseline 60 min after insulin injection (170±30.8 vs 125±15.4 pmol/l, p<0.05). These results indicate that the use of beta-blockers, in particular penbutolol, for mild to moderate hypertension may be considered the treatment of choice also in non-insulin-dependent diabetics at the therapeutic doses employed. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
