دورية أكاديمية
Foxp3+ follicular regulatory T cells control the germinal center response
| العنوان: | Foxp3+ follicular regulatory T cells control the germinal center response |
|---|---|
| المؤلفون: | Linterman, Michelle, Pierson, Wim, Lee, Candice, Kallies, Axel, Kawamoto, Shimpei, other, and |
| المصدر: | Nature Medicine |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2011 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| مصطلحات موضوعية: | Animals, B-Lymphocytes/*metabolism, CXCR5/metabolism, Cell Differentiation/*immunology, DNA-Binding Proteins/genetics, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Forkhead Transcription Factors/*metabolism, Germinal Center/*immunology, Humans, Immunohistochemistry, Inbred C57BL, Knockout, Membrane Proteins/metabolism, Mice, Nonparametric, Proto-Oncogene Proteins c-bcl-6, Receptors, Regulatory/*immunology/metabolism/physiology, Repressor Proteins/metabolism, Self Tolerance/*immunology, Statistics, T-Lymphocytes |
| الوصف: | Follicular helper (T FH ) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of T FH numbers maintains self tolerance. We describe a population of Foxp3 + Blimp-1 + CD4 + T cells constituting 10–25% of the CXCR5 high PD-1 high CD4 + T cells found in the germinal center after immunization with protein antigens. These follicular regulatory T (T FR ) cells share phenotypic characteristics with T FH and conventional Foxp3 + regulatory T (T reg ) cells yet are distinct from both. Similar to T FH cells, T FR cell development depends on Bcl-6, SLAM-associated protein (SAP), CD28 and B cells; however, T FR cells originate from thymic-derived Foxp3 + precursors, not naive or T FH cells. T FR cells are suppressive in vitro and limit T FH cell and germinal center B cell numbers in vivo . In the absence of T FR cells, an outgrowth of non–antigen-specific B cells in germinal centers leads to fewer antigen-specific cells. Thus, the T FH differentiation pathway is co-opted by T reg cells to control the germinal center response. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://eprints.qut.edu.au/106828/3/ukmss-35883.pdfTest; Linterman, Michelle, Pierson, Wim, Lee, Candice, Kallies, Axel, Kawamoto, Shimpei, & other, and (2011) Foxp3+ follicular regulatory T cells control the germinal center response. Nature Medicine, 17(8), pp. 975-982.; https://eprints.qut.edu.au/106828Test/; Faculty of Health; Institute of Health and Biomedical Innovation |
| الإتاحة: | https://doi.org/10.1038/nm.2425Test https://eprints.qut.edu.au/106828Test/ |
| حقوق: | free_to_read ; Consult author(s) regarding copyright matters ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.C95BF5B0 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |