المؤلفون: Simona, Schäfer, Elisa, Mallick, Louisa, Schwed, Alexandra, König, Jian, Zhao, Nicklas, Linz, Timothy Hadarsson, Bodin, Johan, Skoog, Nina, Possemis, Daphne, Ter Huurne, Anna, Zettergren, Silke, Kern, Simona, Sacuiu, Inez, Ramakers, Ingmar, Skoog, Johannes, Tröger

المساهمون: RS: MHeNs - R3 - Neuroscience, Basic Neuroscience 2, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychology 1, Psychology 2

المصدر: Journal of Alzheimer's Disease, 91(3), 1165-1171. IOS Press

مصطلحات موضوعية: Psychiatry and Mental health, Clinical Psychology, General Neuroscience, General Medicine, Geriatrics and Gerontology

الوصف: BACKGROUND: Modern prodromal Alzheimer's disease (AD) clinical trials might extend outreach to a general population, causing high screen-out rates and thereby increasing study time and costs. Thus, screening tools that cost-effectively detect mild cognitive impairment (MCI) at scale are needed.OBJECTIVE: Develop a screening algorithm that can differentiate between healthy and MCI participants in different clinically relevant populations.METHODS: Two screening algorithms based on the remote ki:e speech biomarker for cognition (ki:e SB-C) were designed on a Dutch memory clinic cohort (N = 121) and a Swedish birth cohort (N = 404). MCI classification was each evaluated on the training cohort as well as across on the unrelated validation cohort.RESULTS: The algorithms achieved a performance of AUC 0.73 and AUC 0.77 in the respective training cohorts and AUC 0.81 in the unseen validation cohort.CONCLUSION: The results indicate that a ki:e SB-C based algorithm robustly detects MCI across different cohorts and languages, which has the potential to make current trials more efficient and improve future primary health care.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309dee186fd0b3643ecb8375d6ea4d0fTest
https://doi.org/10.3233/jad-220762Test

المؤلفون: Céline Labbé, Alexandra König, Hali Lindsay, Nicklas Linz, Johannes Tröger, Philippe Robert

المصدر: Alzheimer's & Dementia. 18

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::58be6d34fa42c506653dbb6c3fbeee93Test
https://doi.org/10.1002/alz.064486Test

المؤلفون: Johan Skoog, Elisa Mallick, Timothy Hadarsson Bodin, Mario Mina, Nicklas Linz, Johannes Tröger, Ingmar Skoog

المصدر: Alzheimer's & Dementia. 18

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9e50e4564a3b9190a4c6b5b8e57b2222Test
https://doi.org/10.1002/alz.067821Test

المؤلفون: Nicklas Linz, Elisa Mallick, Mario Mina, Nina Possemis, Alexandra König, Daphne B.G. ter Huurne, Inez H.G.B. Ramakers, Johannes Tröger

المصدر: Alzheimer's & Dementia. 18

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d76b16caf1c911123fd79b740922f60eTest
https://doi.org/10.1002/alz.061600Test

المؤلفون: Sarah Gregory, John Harrison, Janna Herrmann, Matthew Hunter, Natalie Jenkins, Alexandra König, Nicklas Linz, Saturnino Luz, Elisa Mallick, Hannah Pullen, Miles Welstead, Stephen Ruhmel, Johannes Tröger, Craig W. Ritchie

مصطلحات موضوعية: Medicine, Neuroscience, Biomarkers, Health Care, Diseases, Geriatrics and Gerontology, Neurology and Neuromuscular Diseases, Aged Health Care, speech, Alzheimer's disease, cognition, acceptability, feasibility

الوصف: Introduction Digital cognitive assessments are gathering importance for the decentralized remote clinical trials of the future. Before including such assessments in clinical trials, they must be tested to confirm feasibility and acceptability with the intended participant group. This study presents usability and acceptability data from the Speech on the Phone Assessment (SPeAk) study. Methods Participants (N = 68, mean age 70.43 years, 52.9% male) provided demographic data and completed baseline and 3-month follow-up phone based assessments. The baseline visit was administered by a trained researcher and included a spontaneous speech assessment and a brief cognitive battery (immediate and delayed recall, digit span, and verbal fluency). The follow-up visit repeated the cognitive battery which was administered by an automatic phone bot. Participants were randomized to receive their cognitive test results acer the final or acer each study visit. Participants completed acceptability questionnaires electronically acer each study visit. Results There was excellent retention (98.5%), few technical issues (n = 5), and good interrater reliability. Participants rated the assessment as acceptable, confirming the ease of use of the technology and their comfort in completing cognitive tasks on the phone. Participants generally reported feeling happy to receive the results of their cognitive tests, and this disclosure did not cause participants to feel worried. Discussion The results from this usability and acceptability analysis suggest that completing this brief battery of cognitive tests via a telephone call is both acceptable and feasible in a midlife-to-older adult population in the United Kingdom, living at risk for Alzheimer's disease.

العلاقة: https://figshare.com/articles/dataset/Data_Sheet_1_Remote_data_collection_speech_analysis_in_people_at_risk_for_Alzheimer_s_disease_dementia_usability_and_acceptability_results_docx/24305929Test

الإتاحة: https://doi.org/10.3389/frdem.2023.1271156.s001Test
https://figshare.com/articles/dataset/Data_Sheet_1_Remote_data_collection_speech_analysis_in_people_at_risk_for_Alzheimer_s_disease_dementia_usability_and_acceptability_results_docx/24305929Test

المؤلفون: Alexandra König, Inez H.G.B. Ramakers, Nicklas Linz, Radia Zeghari, Philippe Robert

المصدر: Alzheimer's & Dementia. 17

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1975752bd73afb962c29c4472a5c74e1Test
https://doi.org/10.1002/alz.049766Test

المؤلفون: Alexandra König, Radia Zeghari, Rachid Guerchouche, Francois Bremond, Vincent Bultingaire, Philippe Robert, Nicklas Linz

المصدر: Alzheimer's & Dementia. 17

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4423912e3805f30f80af1fa0144f8982Test
https://doi.org/10.1002/alz.050302Test

المؤلفون: Daphne BG ter Huurne, Inez HGB Ramakers, Nicklas Linz, Alexandra König, Kai Langel, Hali Lindsay, Frans RJ Verhey, Marjolein de Vugt

المصدر: Alzheimer's & Dementia. 17

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b7c5029ff869831abb062a6ee32eb83bTest
https://doi.org/10.1002/alz.050380Test

المؤلفون: Pascale Lemoine, Philippe Robert, Vincent Bultingaire, Alexandra König, Nicklas Linz, Radia Zeghari, Rachid Guerchouche, Inez H.G.B. Ramakers

المصدر: Alzheimer's & Dementia. 16

مصطلحات موضوعية: 0303 health sciences, Telemedicine, Epidemiology, business.industry, Remote patient monitoring, Health Policy, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, Medicine, Dementia, Neurology (clinical), Medical emergency, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0cb638aff51460d2be335b03b85cdca4Test
https://doi.org/10.1002/alz.047345Test

المؤلفون: Radia Zeghari, Robert Philippe, Valeria Manera, Nicklas Linz, Rachid Guerchouche, Alexandra König

المصدر: Alzheimer's & Dementia. 15

مصطلحات موضوعية: Telemedicine, Multimedia, Epidemiology, Computer science, Health Policy, computer.software_genre, Cognitive test, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Automatic speech, Neurology (clinical), Geriatrics and Gerontology, Rural area, computer

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b66d189ac1e50ce299187f6121fb3e5aTest
https://doi.org/10.1016/j.jalz.2019.09.064Test