دورية أكاديمية
Amyloid beta plaque accumulation with longitudinal [18F]AZD4694 PET
| العنوان: | Amyloid beta plaque accumulation with longitudinal [18F]AZD4694 PET |
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| المؤلفون: | Joseph Therriault, Firoza Z. Lussier, Cécile Tissot, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Vanessa Pallen, Gleb Bezgin, Stijn Servaes, Peter Kunach, Yi‐Ting Wang, Jaime Fernandez‐Arias, Marie Vermeiren, Tharick A. Pascoal, Gassan Massarweh, Paolo Vitali, Jean‐Paul Soucy, Paramita Saha‐Chaudhuri, Serge Gauthie, Pedro Rosa‐Neto |
| المصدر: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 3, Pp n/a-n/a (2023) |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Alzheimer's disease, amyloid beta, positron emission tomography, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| الوصف: | Introduction [18F]AZD4694 is an amyloid beta (Aβ) imaging agent used in several observational studies and clinical trials. However, no studies have yet published data on longitudinal Aβ accumulation measured with [18F]AZD4694. Methods We assessed 146 individuals who were evaluated with [18F]AZD4694 at baseline and 2‐year follow‐up. We calculated annual rates of [18F]AZD4694 change for clinically defined and biomarker‐defined groups Results Cognitively unimpaired (CU) older adults displayed subtle [18F]AZD4694 standardized uptake value ratio (SUVR) accumulation over the follow‐up period. In contrast, Aβ positive CU older adults displayed higher annual [18F]AZD4694 SUVR increases. [18F]AZD4694 SUVR accumulation in Aβ positive mild cognitive impairment (MCI) and dementia was modest across the neocortex Discussion Larger increases in [18F]AZD4694 SUVR were observed in CU individuals who had abnormal amyloid positron emission tomography levels at baseline. [18F]AZD4694 can be used to monitor Aβ levels in therapeutic trials as well as clinical settings, particularly prior to initiating anti‐amyloid therapies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2352-8729 |
| العلاقة: | https://doi.org/10.1002/dad2.12391Test; https://doaj.org/toc/2352-8729Test; https://doaj.org/article/0743f6a4d88b477e9305928c3c9f2449Test |
| DOI: | 10.1002/dad2.12391 |
| الإتاحة: | https://doi.org/10.1002/dad2.12391Test https://doaj.org/article/0743f6a4d88b477e9305928c3c9f2449Test |
| رقم الانضمام: | edsbas.9E946BF7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23528729 |
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| DOI: | 10.1002/dad2.12391 |