SIRT1 (rs3740051) role in pituitary adenoma development
| العنوان: | SIRT1 (rs3740051) role in pituitary adenoma development |
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| المؤلفون: | Greta Morkunaite, Loresa Kriauciuniene, Rasa Liutkeviciene, Brigita Glebauskiene, Alvita Vilkeviciute |
| المصدر: | BMC Medical Genetics, Vol 20, Iss 1, Pp 1-7 (2019) BMC Medical Genetics BMC medical genetics, London : BioMed Central, 2019, vol. 20, no. 1, 185, p. 1-7 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adenoma, Adult, Male, 0301 basic medicine, lcsh:Internal medicine, medicine.medical_specialty, Genotype, lcsh:QH426-470, Pituitary neoplasm, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Sirtuin 1, Recurrence, Pituitary adenoma, Internal medicine, Genetics, medicine, Humans, Neoplasm Invasiveness, Pituitary Neoplasms, Allele, lcsh:RC31-1245, 616.432-006.55 [udc], Genotyping, Alleles, Genetics (clinical), Aged, rs3740051) gene polymorphisms, business.industry, Haplotype, Pituitary neoplasms, genetics, Polymorphism, genetic, Middle Aged, medicine.disease, Invasiveness, Pituitary Hormones, lcsh:Genetics, 030104 developmental biology, Case-Control Studies, 030220 oncology & carcinogenesis, SIRT1 (rs4746720, Female, business, Research Article |
| الوصف: | Background Our purpose was to determine if SIRT1 (rs4746720, rs3740051) genotypes have an influence on the development of pituitary adenoma (PA). Methods The study group included 142 patients with pituitary adenoma (PA) and the control group consisted of 826 healthy people. The genotyping of SIRT1 (rs4746720, rs3740051) was carried out using the real-time polymerase chain reaction method. Results Statistically significant results were obtained in the analysis of SIRT1 rs3740051. Significant differences in genotype (G/G, G/A, A/A) distribution were obtained comparing patients with PA without recurrence and PA with recurrence (0, 17.9, 82.1% vs. 6.7, 6.7, 86.7%, respectively, p = 0.022). Also, statistically significant differences were observed when comparing the genotype (G/G, G/A, A/A) distribution in the non-invasive PA group and the invasive PA group (3.4, 25.9, 70.7% vs. 0, 8.3, 91.7%, respectively, p = 0.003), and allele G was less frequently observed in invasive PA, than in non-invasive PA (4.2% vs. 16.4%, p p = 0.007) and each allele A (OR = 0.229; 95% CI:0.091–0.575; p = 0.002) were associated with lower odds of occurring an invasive PA. Conclusions Our study revealed that SIRT1 rs3740051 is associated with PA recurrence and invasiveness. The haplotype containing alleles C-A in rs12778366-rs3740051 was found to be associated with increased odds of PA development as well. |
| وصف الملف: | application/pdf |
| تدمد: | 1471-2350 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd94f46dc223c760d23c524e643958aTest https://doi.org/10.1186/s12881-019-0892-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8fd94f46dc223c760d23c524e643958a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712350 |
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