المؤلفون: Melissa A. Marton, Joshua Gould, Alykhan F. Shamji, Levi A. Garraway, Andrew L. Kung, Yan Ling Zhang, Wendy Winckler, Kenneth N. Ross, Pablo Tamayo, Stuart L. Schreiber, Griselda Metta Yvone, Michelle Palmer, Todd R. Golub, Aristotle M. Mannan, Andrew Crenshaw, Aviad Tsherniak, Bang Wong, Michael Foley, Barbara A. Weir, Channing Yu, Bradley Taylor

المصدر: Nature biotechnology
Nature biotechnology, vol 34, iss 4

مصطلحات موضوعية: 0301 basic medicine, Genotyping Techniques, Phenotypic screening, Drug Resistance, Biomedical Engineering, Bioengineering, Computational biology, Biology, Applied Microbiology and Biotechnology, Article, Cell Line, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Cell Line, Tumor, Neoplasms, Genotype, medicine, Animals, DNA Barcoding, Taxonomic, Humans, Tumor, Taxonomic, High-Throughput Nucleotide Sequencing, Cancer, medicine.disease, Small molecule, Molecular biology, DNA Barcoding, 3. Good health, 030104 developmental biology, Cell killing, Drug Resistance, Neoplasm, Cell culture, 030220 oncology & carcinogenesis, Neoplasm, Molecular Medicine, Erlotinib, Biotechnology, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d42661725f8e3900a3bb52d9babac5Test
https://doi.org/10.1038/nbt.3460Test

المؤلفون: Kathy Stirrups, Inga Prokopenko, Jeanette Erdmann, Jun Ding, Serena Sanna, Patricia B. Munroe, Ramaiah Nagaraja, Antonella Mulas, Christian Fuchsberger, Cameron D. Palmer, Simon C. Potter, Ruth J. F. Loos, Nicole Soranzo, Tuomas O. Kilpeläinen, Michael Boehnke, Sekar Kathiresan, Francesco Cucca, David Altshuler, Hyun Min Kang, Melissa Parkin, Neil Robertson, Heribert Schunkert, Timothy M. Frayling, Gonçalo R. Abecasis, Arne Pfeufer, Toby Johnson, Joshua C. Randall, Mark I. McCarthy, Joel N. Hirschhorn, Nilesh J. Samani, Anne U. Jackson, Tanya M. Teslovich, Eleanor Wheeler, Benjamin F. Voight, Yun Li, Carlo Sidore, Panagiotis Deloukas, N P Burtt, Nigel W. Rayner, Richa Saxena, Peter S. Chines, Jared Maguire, Wendy Winckler, Cecilia M. Lindgren, Andrew P. Morris, Iris M. Heid, Christopher Newton-Cheh, Inês Barroso, Elizabeth K. Speliotes

المصدر: PLoS Genet. 8:e1002793 (2012)
PLoS Genetics, Vol 8, Iss 8, p e1002793 (2012)
PLoS Genetics

مصطلحات موضوعية: Cancer Research, Genotyping Techniques, Genome-wide association study, 030204 cardiovascular system & hematology, QH426-470, Cardiovascular, 0302 clinical medicine, Endocrinology, Gene Frequency, Genetics (clinical), Oligonucleotide Array Sequence Analysis, 2. Zero hunger, Genetics, 0303 health sciences, Anthropometry, Statistics, 3. Good health, Phenotype, Cardiovascular Diseases, Medicine, Research Article, Genotype, Quantitative Trait Loci, Genomics, Single-nucleotide polymorphism, Quantitative trait locus, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, SNP, Humans, Metabolomics, Molecular Biology, Genotyping, Ecology, Evolution, Behavior and Systematics, Alleles, 030304 developmental biology, Genetic association, Diabetic Endocrinology, 0604 Genetics, Genome, Human, Human Genetics, Diabetes Mellitus Type 2, Diabetes Mellitus, Type 2, Metabolic Disorders, Mathematics, Genome-Wide Association Study, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b37c5626e6089342d54f61300353c4Test
https://ora.ox.ac.uk/objects/uuid:00d09741-e53b-4d8b-9852-aae6b9fc0ab7Test

المؤلفون: Mehran Taherian, Debra Bradbury, Emmanouil T. Dermitzakis, Manuel A. Rivas, Deborah C. Mash, Ayellet V. Segrè, Luan Lin, Ping Guan, Kimberly Ramsey, Mary Barcus, Deborah Colantuoni, Xiaoquan Wen, Julian Maller, Ferran Reverter, Laura A. Siminoff, Bryan Gillard, Dana R. Valley, Gen Li, Jeffery P. Struewing, Philip A. Branton, Roderic Guigó, Nancy Roche, Charles Shive, Christopher Choi, Johnell Fleming, Timothée Flutre, Latarsha J. Carithers, Taylor Young, Anuar Konkashbaev, Matthew Stephens, Daniel G. MacArthur, Rick Hasz, Mark I. McCarthy, Joel N. Hirschhorn, Sara Mostafavi, Lucas D. Ward, Amanda Brown, Ki Sung Um, Manolis Kellis, Robin Burges, Eric R. Gamazon, Heather M. Traino, Gary F. Temple, Karna Robinson, Leslie H. Sobin, Daphne Koller, Halit Ongen, Bernadette Mestichelli, John T. Lonsdale, Kimberly M. Valentino, Ellen Gelfand, David Tabor, Taru Tukiainen, Mike Salvatore, Gary Walters, Susan L. Sullivan, Jason Bridge, Carolyn C. Compton, Kenneth W. Hambright, Joy T. Boyer, Bin Zhang, Anita H. Undale, Michael Sammeth, Helen M. Moore, Nancy J. Cox, Andrey A. Shabalin, Kenyon Erickson, Nicole C. Lockhart, Gad Getz, Pushpa Hariharan, Benjamin Iriarte, Jakob M. Goldmann, Pouya Kheradpour, John Syron, Jimmie B. Vaught, Jun Zhu, Hae Kyung Im, Jean Monlong, John Seleski, Marta Melé, Edmund Lo, Yvonne Marcus, Pedro G. Ferreira, Stephen A. Buia, Liqun Qi, Greg E. Korzeniewski, Michael T. Moser, Ivan Rusyn, Andrew B. Nobel, Casandra A. Trowbridge, Timothy J. Sullivan, Chunrong Lu, Barbara A. Foster, Laura Barker, Jun Liu, Shenpei Wu, Anna M. Smith, Joanne P. Demchok, Dan L. Nicolae, Jeffrey A. Thomas, Jonathan K. Pritchard, Sherilyn Sawyer, Fred A. Wright, Wendy Winckler, Angela Britton, Zhidong Tu, Jorge Tejada, David S. DeLuca, Yi-Hui Zhou, Roger Little, Jeffrey McLean, Simona Volpi, Tõnu Esko, Kristin G. Ardlie, Monkol Lek, Daniel C. Rohrer, Susan E. Koester, Harold Magazine, Mark Miklos, Quan Long, Jialiang Yang, Cameron D. Palmer, Maghboeba Mosavel, Scott D. Jewell, Tuuli Lappalainen, Alexis Battle, Ellen Karasik, Margaret J. Basile, Saboor Shad, Denee Tidwell, Yan Meng, Chana A. Rabiner, Tao Huang

المساهمون: Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro), NIH, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)

المصدر: Science
Science, American Association for the Advancement of Science, 2015, 348 (6235), pp.648-660. ⟨10.1126/science.1262110⟩

مصطلحات موضوعية: RNA, Untranslated, Genotype, RNA Splicing, [SDV]Life Sciences [q-bio], Quantitative Trait Loci, Blood Pressure, Pilot Projects, Quantitative trait locus, Biology, Expression quantitative trait loci, eQTL, Article, Human disease, Genotype-Tissue Expression, Genetic variation, Humans, Disease, Gene Regulatory Networks, Alleles, Biomedicine, Genetics, Regulation of gene expression, Multidisciplinary, Genome, Human, Sequence Analysis, RNA, business.industry, GTPase-Activating Proteins, Genetic Variation, Tibial Arteries, Gene Expression Regulation, Organ Specificity, Multigene Family, Transcriptome, business, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4415d157f3f793e92cd1f5af60e0bbTest
https://hal.archives-ouvertes.fr/hal-01157916Test

المؤلفون: Noël P. Burtt, Camilla Cervin, Peter Almgren, Joel N. Hirschhorn, Thomas J. Hudson, Tiinamaija Tuomi, Daniel Gaudet, Kristin G. Ardlie, Leif Groop, Maria Sun, Mark J. Daly, Wendy Winckler, Paul I.W. de Bakker, Johan Holmkvist, David Altshuler

المصدر: Diabetes. 54:2336-2342

مصطلحات موضوعية: Genotype, Endocrinology, Diabetes and Metabolism, Mutation, Missense, Single-nucleotide polymorphism, Type 2 diabetes, Biology, Polymorphism, Single Nucleotide, Odds Ratio, Internal Medicine, medicine, Humans, Genetic Predisposition to Disease, Hepatocyte Nuclear Factor 1-alpha, Genotyping, Genetic association, Genetics, Haplotype, Case-control study, Nuclear Proteins, Odds ratio, medicine.disease, DNA-Binding Proteins, Diabetes Mellitus, Type 2, Haplotypes, Case-Control Studies, Hepatocyte Nuclear Factor 1, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2e4fb3693dcf3d1ae1545a0f02f452Test
https://doi.org/10.2337/diabetes.54.8.2336Test

المؤلفون: Mark J. Daly, Daniel Gaudet, Robert R. Graham, Thomas J. Hudson, Peter Almgren, David Altshuler, Wendy Winckler, Leif Groop, Kristin G. Ardlie, Paul I.W. de Bakker, Tiinamaija Tuomi, Joel N. Hirschhorn, Maria Sun

المصدر: Diabetes. 54:886-892

مصطلحات موضوعية: Adult, Linkage disequilibrium, Genotype, Endocrinology, Diabetes and Metabolism, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Risk Factors, Odds Ratio, Internal Medicine, Humans, SNP, Genetic Predisposition to Disease, Risk factor, Promoter Regions, Genetic, Genotyping, Genetics, Haplotype, Chromosome Mapping, Odds ratio, Middle Aged, Phosphoproteins, DNA-Binding Proteins, Diabetes Mellitus, Type 2, Hepatocyte Nuclear Factor 4, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f53b069ee6a490fbddff4debf0c1faTest
https://doi.org/10.2337/diabetes.54.3.886Test

المؤلفون: Christopher J. Groves, Mark I. McCarthy, Anette P. Gjesing, Wendy Winckler, Bahram Jafar-Mohammadi, Torben Hansen, Heather M. Stringham, Andrew T. Hattersley, Anna L. Gloyn, Francis S. Collins, Blanca M. Herrera, David Altshuler, Andrew P. Morris, Michael N. Weedon, Alex S. F. Doney, Torsten Lauritzen, Amy J. Swift, Johanna Kuusisto, Michael Boehnke, Andrew D. Morris, Colin N. A. Palmer, Markku Laakso, Oluf Pedersen, Timothy M. Frayling

المصدر: Jafar-Mohammadi, B, Groves, C J, Gjesing, A P, Herrera, B M, Winckler, W, Stringham, H M, Morris, A P, Lauritzen, T, Doney, A S F, Morris, A D, Weedon, M N, Swift, A J, Kuusisto, J, Laakso, M, Altshuler, D, Hattersley, A T, Collins, F S, Boehnke, M, Hansen, T, Pedersen, O, Palmer, C N A, Frayling, T M, Gloyn, A L, McCarthy, M I & DIAGRAM Consortium 2011, ' A role for coding functional variants in HNF4A in type 2 diabetes susceptibility ', Diabetologia, vol. 54, no. 1, pp. 111-9 . https://doi.org/10.1007/s00125-010-1916-4Test

مصطلحات موضوعية: Adult, Male, Genotype, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Biology, Article, Internal Medicine, medicine, Humans, Genetic Predisposition to Disease, Gene, Aged, Genetic association, Genetics, Middle Aged, medicine.disease, Minor allele frequency, Hepatocyte nuclear factors, Diabetes Mellitus, Type 2, Hepatocyte Nuclear Factor 4, Hepatocyte nuclear factor 4, Mutation, Female, TCF7L2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc687bdebfc930d1df7baafd89207930Test
http://ora.ox.ac.uk/objects/uuid:705b6c24-3638-4e8a-a1f0-2099d4d1cbabTest

المؤلفون: Margaret Morgan, George M. Weinstock, Mark A. Watson, Harold E. Varmus, Valerie W. Rusch, Megan Hanna, Qunyuan Zhang, Ingrid B. Borecki, Carrie Sougnez, Neal I. Lindeman, James T. Robinson, Marc Ladanyi, Stephen R. Broderick, Alex H. Ramos, Levi A. Garraway, Michael A. Province, Mark G. Kris, William Pao, Margaret R. Spitz, John Douglas Mcpherson, Richard A. Gibbs, John R. Osborne, Sven Perner, Eric S. Lander, Laura A. Johnson, Bruce E. Johnson, David G. Beer, Jack A. Roth, Richard K. Wilson, John D. Minna, William D. Travis, Andrew C. Chang, Adi F. Gazdar, David A. Wheeler, William M. Lin, David Twomey, Barbara A. Weir, Frances A. Shepherd, Heidi Greulich, Derek Y. Chiang, Rameen Beroukhim, Jeonghee Cho, Li Ding, Gad Getz, Mark Nadel, Mitsuo Sato, Mark B. Orringer, Roman K. Thomas, Stacey Gabriel, Maureen F. Zakowski, Lucian R. Chirieac, Matthew Meyerson, Brad Ozenberger, Yoshitaka Fujii, Justine A. Barletta, Akihiko Yoshizawa, Ignacio I. Wistuba, Ming-Sound Tsao, Aldi T. Kraja, Michele S. Woo, Mark A. Rubin, Hidefumi Sasaki, Roel G.W. Verhaak, Soyoung Yu, Wendy Winckler, Alex E. Lash, Thomas J. Giordano, Kinjal Shah, Ling Lin, Elaine R. Mardis

مصطلحات موضوعية: Lung Neoplasms, Genotype, Thyroid Nuclear Factor 1, Loss of Heterozygosity, Single-nucleotide polymorphism, Adenocarcinoma, Polymorphism, Single Nucleotide, Proto-Oncogene Mas, Article, Loss of heterozygosity, Cell Line, Tumor, Neoplasms, Gene duplication, medicine, Humans, Lung cancer, Genetics, Chromosomes, Human, Pair 14, Multidisciplinary, biology, Genome, Human, Gene Amplification, Intracellular Signaling Peptides and Proteins, Cancer, Nuclear Proteins, Genomics, medicine.disease, biology.protein, Cancer research, Human genome, RNA Interference, Chromosome Deletion, NK2 homeobox 1, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1feb379228a55ead04e0196cea71abTest
https://europepmc.org/articles/PMC2538683Test/

المؤلفون: Mark I. McCarthy, Joel N. Hirschhorn, Daniel Gaudet, Kristina Bengtsson Boström, Michael N. Weedon, Shaun Purcell, Peter Almgren, Robert R. Graham, Steven A. McCarroll, Mark Walker, Leif Groop, Wendy Winckler, Tiinamaija Tuomi, Mark J. Daly, Graham A. Hitman, Andrew T. Hattersley, David Altshuler, Timothy M. Frayling, Kristin G. Ardlie

المصدر: Diabetes. 56(3)

مصطلحات موضوعية: Male, Linkage disequilibrium, Genotype, Endocrinology, Diabetes and Metabolism, Single-nucleotide polymorphism, Type 2 diabetes, Biology, Polymorphism, Single Nucleotide, Maturity onset diabetes of the young, Linkage Disequilibrium, Polymorphism (computer science), Glucokinase, Internal Medicine, medicine, Basic Helix-Loop-Helix Transcription Factors, Humans, Genetic Predisposition to Disease, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 1-beta, Genetics, Homeodomain Proteins, Genetic Variation, medicine.disease, Human genetics, Diabetes Mellitus, Type 2, Hepatocyte Nuclear Factor 4, Trans-Activators, Female, Common disease-common variant

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48810fbda7a45e94a58cd62347ecc42Test
http://ora.ox.ac.uk/objects/uuid:8bc7838c-1aba-4192-92a0-519060a7d8aeTest

المؤلفون: William J. Catalona, Holger Moch, Alissa C. Baker, Liuda Ziaugra, Jonathan A. Fletcher, Kinjal Shah, Jeffrey C. Lee, John D. Minna, Meng Wang, Kirsten D. Mertz, Hidefumi Sasaki, Frederic J. Kaye, Rick Nicoletti, Caroline Emery, Ralph M. Debiasi, Massimo Loda, F. Stephen Hodi, Wendy Winckler, Stan F. Nelson, Meenhard Herlyn, William M. Lin, Luc Girard, Paul S. Mischel, Ingo K. Mellinghoff, Stephan N. Wagner, George D. Demetri, Kenneth C. Anderson, Glenn Dranoff, Thomas Zander, Sabina Signoretti, Mark A. Rubin, Linda M. Liau, Adi F. Gazdar, Timothy F. Cloughesy, Matthew Meyerson, Mary Goyette, Kwok-Kin Wong, Whei Feng, Rameen Beroukhim, Stacey Gabriel, Jordi Barretina, Laura E. MacConnaill, Kuntal Majmudar, Levi A. Garraway, William R. Sellers, Scott A. Armstrong, Michael Peyton, Reinhard Dummer, Amit Dutt, Charlie Hatton, Heidi Greulich, Roman K. Thomas, Thomas LaFramboise

المصدر: Nature genetics. 39(3)

مصطلحات موضوعية: Genetics, Mutation, Oncogene, Genotype, Genome, Human, Gene Expression Profiling, DNA Mutational Analysis, Cancer, Tumor initiation, Oncogenes, Biology, medicine.disease_cause, medicine.disease, Gene expression profiling, Neoplasms, medicine, Humans, Gene, Genotyping

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2567b319db4c1adfbf38fd3c5c60d386Test
https://pubmed.ncbi.nlm.nih.gov/17325673Test

المؤلفون: Peter Donnelly, David Altshuler, Ronald E. Bontrop, Robert C. Onofrio, Stacey Gabriel, Gilean McVean, Gavin J. McDonald, Daniel J. Richter, Wendy Winckler, David Reich, Simon Myers

المصدر: Science (New York, N.Y.). 308(5718)

مصطلحات موضوعية: Genotype, Pan troglodytes, Recombination rate, Locus (genetics), Biology, Polymorphism, Single Nucleotide, DNA sequencing, Linkage Disequilibrium, Evolution, Molecular, chemistry.chemical_compound, HLA Antigens, Sequence Homology, Nucleic Acid, Animals, Chromosomes, Human, Humans, PRDM9, Alleles, Genetics, Recombination, Genetic, Multidisciplinary, Genome, Base Sequence, Genome, Human, Chromosome Mapping, Chromosomes, Mammalian, Markov Chains, Globins, chemistry, Haplotypes, Evolutionary biology, Monte Carlo Method, Statistical evidence, Recombination, DNA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac09c780ad75de3279cbd8b4f49bb103Test
https://pubmed.ncbi.nlm.nih.gov/15802591Test