المؤلفون: Bancroft, EK, Page, EC, Castro, E, Lilja, H, Vickers, A, Sjoberg, D, Assel, M, Foster, CS, Mitchell, G, Drew, K, Mæhle, L, Axcrona, K, Evans, DG, Bulman, B, Eccles, D, McBride, D, van Asperen, C, Vasen, H, Kiemeney, LA, Ringelberg, J, Cybulski, C, Wokolorczyk, D, Selkirk, C, Hulick, PJ, Bojesen, A, Skytte, A-B, Lam, J, Taylor, L, Oldenburg, R, Cremers, R, Verhaegh, G, van Zelst-Stams, WA, Oosterwijk, JC, Blanco, I, Salinas, M, Cook, J, Rosario, DJ, Buys, S, Conner, T, Ausems, MG, Ong, K-R, Hoffman, J, Domchek, S, Powers, J, Teixeira, MR, Maia, S, Foulkes, WD, Taherian, N, Ruijs, M, Helderman-van den Enden, AT, Izatt, L, Davidson, R, Adank, MA, Walker, L, Schmutzler, R, Tucker, K, Kirk, J, Hodgson, S, Harris, M, Douglas, F, Lindeman, GJ, Zgajnar, J, Tischkowitz, M, Clowes, VE, Susman, R, Ramón y Cajal, T, Patcher, N, Gadea, N, Spigelman, A, van Os, T, Liljegren, A, Side, L, Brewer, C, Brady, AF, Donaldson, A, Stefansdottir, V, Friedman, E, Chen-Shtoyerman, R, Amor, DJ, Copakova, L, Barwell, J, Giri, VN, Murthy, V, Nicolai, N, Teo, S-H, Greenhalgh, L, Strom, S, Henderson, A, McGrath, J, Gallagher, D, Aaronson, N, Ardern-Jones, A, Bangma, C, Dearnaley, D, Costello, P, Eyfjord, J, Rothwell, J, Falconer, A, Gronberg, H, Hamdy, FC, Johannsson, O, Khoo, V, Kote-Jarai, Z, Lubinski, J, Axcrona, U, Melia, J, McKinley, J, Mitra, AV, Moynihan, C, Rennert, G, Suri, M, Wilson, P, Killick, E, IMPACT Collaborators, Moss, S, Eeles, RA

المساهمون: Dearnaley, David, Kote-Jarai, Zsofia, Eeles, Rosalind

مصطلحات موضوعية: IMPACT Collaborators, Prostate, Humans, Prostatic Neoplasms, Genetic Predisposition to Disease, Prostate-Specific Antigen, Biopsy, Predictive Value of Tests, Genotype, Mutation, Genes, BRCA1, BRCA2, Patient Selection, Adult, Aged, Middle Aged, Male, Early Detection of Cancer

الوصف: BACKGROUND: Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls) is an international consortium of 62 centres in 20 countries evaluating the use of targeted PCa screening in men with BRCA1/2 mutations. OBJECTIVE: To report the first year's screening results for all men at enrollment in the study. DESIGN, SETTING AND PARTICIPANTS: We recruited men aged 40-69 yr with germline BRCA1/2 mutations and a control group of men who have tested negative for a pathogenic BRCA1 or BRCA2 mutation known to be present in their families. All men underwent prostate-specific antigen (PSA) testing at enrollment, and those men with PSA >3 ng/ml were offered prostate biopsy. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: PSA levels, PCa incidence, and tumour characteristics were evaluated. The Fisher exact test was used to compare the number of PCa cases among groups and the differences among disease types. RESULTS AND LIMITATIONS: We recruited 2481 men (791 BRCA1 carriers, 531 BRCA1 controls; 731 BRCA2 carriers, 428 BRCA2 controls). A total of 199 men (8%) presented with PSA >3.0 ng/ml, 162 biopsies were performed, and 59 PCas were diagnosed (18 BRCA1 carriers, 10 BRCA1 controls; 24 BRCA2 carriers, 7 BRCA2 controls); 66% of the tumours were classified as intermediate- or high-risk disease. The positive predictive value (PPV) for biopsy using a PSA threshold of 3.0 ng/ml in BRCA2 mutation carriers was 48%-double the PPV reported in population screening studies. A significant difference in detecting intermediate- or high-risk disease was observed in BRCA2 carriers. Ninety-five percent of the men were white, thus the results cannot be generalised to all ethnic groups. CONCLUSIONS: The IMPACT screening network will be useful for targeted PCa screening studies in ...

وصف الملف: Print-Electronic; 499; application/pdf

العلاقة: European urology, 2014, 66 (3), pp. 489 - 499; https://repository.icr.ac.uk/handle/internal/3954Test

الإتاحة: https://doi.org/10.1016/j.eururo.2014.01.003Test
https://repository.icr.ac.uk/handle/internal/3954Test

المؤلفون: Bancroft, E. K., Page, E. C., Castro, E., Lilja, H., Vickers, A., Sjoberg, D., Assel, M., Foster, C. S., Mitchell, G., Drew, K., Mæhle, L., Axcrona, K., Evans, D. G., Bulman, B., Eccles, D., McBride, D., van Asperen, C., Vasen, H., Kiemeney, L. A., Ringelberg, J., Cybulski, C., Wokolorczyk, D., Selkirk, C., Hulick, P. J., Bojesen, A., Skytte, A. B., Lam, J., Taylor, L., Oldenburg, R., Cremers, R., Verhaegh, G., van Zelst-Stams, W. A., Oosterwijk, J. C., Blanco, I., Salinas, M., Cook, J., Rosario, D. J., Buys, S., Conner, T., Ausems, M. G., Ong, K. R., Hoffman, J., Domchek, S., Powers, J., Teixeira, M. R., Maia, S., Foulkes, W. D., Taherian, N., Ruijs, M., Helderman-van den Enden, A. T., Izatt, L., Davidson, R., Adank, M. A., Walker, L., Schmutzler, R., Tucker, K., Kirk, J., Hodgson, S., Harris, M., Douglas, F., Lindeman, G. J., Zgajnar, J., Tischkowitz, M., Clowes, V. E., Susman, R., Ramón y Cajal, T., Patcher, N., Gadea, N., Spigelman, A., van Os, T., Liljegren, A., Side, L., Brewer, C., Brady, A. F., Donaldson, A., Stefansdottir, V., Friedman, E., Chen-Shtoyerman, R., Amor, D. J., Copakova, L., Barwell, Julian, Giri, V. N., Murthy, V., Nicolai, N., Teo, S. H., Greenhalgh, L., Strom, S., Henderson, A., McGrath, J., Gallagher, D., Aaronson, N., Ardern-Jones, A., Bangma, C., Dearnaley, D., Costello, P., Eyfjord, J., Rothwell, J., Falconer, A., Gronberg, H., Hamdy, F. C., Johannsson, O., Khoo, V., Kote-Jarai, Z., Lubinski, J., Axcrona, U., Melia, J., McKinley, J., Mitra, A. V., Moynihan, C., Rennert, G., Suri, M., Wilson, P., Killick, E., IMPACT Collaborators, Moss, S., Eeles, R. A.

مصطلحات موضوعية: BRCA1, BRCA2, Prostate cancer, Prostate-specific antigen, Targeted screening, Adult, Aged, Biopsy, Early Detection of Cancer, Genes, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Mutation, Patient Selection, Predictive Value of Tests, Prostate, Prostatic Neoplasms

الوصف: Supplementary data associated with this article can be found, in the online version, at http://dx.doi.org/10.1016/j.eururo.2014.01.003Test. ; BACKGROUND: Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls) is an international consortium of 62 centres in 20 countries evaluating the use of targeted PCa screening in men with BRCA1/2 mutations. OBJECTIVE: To report the first year's screening results for all men at enrollment in the study. DESIGN, SETTING AND PARTICIPANTS: We recruited men aged 40-69 yr with germline BRCA1/2 mutations and a control group of men who have tested negative for a pathogenic BRCA1 or BRCA2 mutation known to be present in their families. All men underwent prostate-specific antigen (PSA) testing at enrollment, and those men with PSA >3 ng/ml were offered prostate biopsy. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: PSA levels, PCa incidence, and tumour characteristics were evaluated. The Fisher exact test was used to compare the number of PCa cases among groups and the differences among disease types. RESULTS AND LIMITATIONS: We recruited 2481 men (791 BRCA1 carriers, 531 BRCA1 controls; 731 BRCA2 carriers, 428 BRCA2 controls). A total of 199 men (8%) presented with PSA >3.0 ng/ml, 162 biopsies were performed, and 59 PCas were diagnosed (18 BRCA1 carriers, 10 BRCA1 controls; 24 BRCA2 carriers, 7 BRCA2 controls); 66% of the tumours were classified as intermediate- or high-risk disease. The positive predictive value (PPV) for biopsy using a PSA threshold of 3.0 ng/ml in BRCA2 mutation carriers was 48%-double the PPV reported in population screening studies. A significant difference in detecting intermediate- or high-risk disease was observed in BRCA2 carriers. Ninety-five percent of the men were white, thus the results ...

العلاقة: http://www.ncbi.nlm.nih.gov/pubmed/24484606Test; European Urology, 2014, 66 (3), pp. 489-499; http://www.sciencedirect.com/science/article/pii/S0302283814000049Test; http://hdl.handle.net/2381/39201Test; S0302-2838(14)00004-9

الإتاحة: https://doi.org/10.1016/j.eururo.2014.01.003Test
http://www.sciencedirect.com/science/article/pii/S0302283814000049Test
http://hdl.handle.net/2381/39201Test