Genetic Features of HIV-1 Integrase Sub-Subtype A6 Predominant in Russia and Predicted Susceptibility to INSTIs
| العنوان: | Genetic Features of HIV-1 Integrase Sub-Subtype A6 Predominant in Russia and Predicted Susceptibility to INSTIs |
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| المؤلفون: | Ilya Lapovok, Charles A. Boucher, Jeroen J. A. van Kampen, Pavel Baryshev, Kireev De, David A. M. C. van de Vijver, Alina Kirichenko, Dimitrios Paraskevis |
| المساهمون: | Virology |
| المصدر: | Viruses, Vol 12, Iss 838, p 838 (2020) Viruses, 12(8):838. Multidisciplinary Digital Publishing Institute (MDPI) Viruses Volume 12 Issue 8 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, Genotype, 030106 microbiology, lcsh:QR1-502, Context (language use), HIV Infections, Drug resistance, HIV Integrase, medicine.disease_cause, INSTI, Article, lcsh:Microbiology, Russia, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Virology, Drug Resistance, Viral, medicine, Prevalence, Humans, Genetic variability, HIV Integrase Inhibitors, genetic barrier, A6, Phylogeny, Genetics, Mutation, Polymorphism, Genetic, biology, virus diseases, Sequence Analysis, DNA, Integrase, phylogenetics, 030104 developmental biology, Infectious Diseases, founder effect, Cohort, biology.protein, Hiv 1 integrase, HIV-1, Female, integrase, L74I, polymorphisms, Founder effect |
| الوصف: | The increasing use of the integrase strand transfer inhibitor (INSTI) class for the treatment of HIV-infection has pointed to the importance of analyzing the features of HIV-1 subtypes for an improved understanding of viral genetic variability in the occurrence of drug resistance (DR). In this study, we have described the prevalence of INSTI DR in a Russian cohort and the genetic features of HIV-1 integrase sub-subtype A6. We included 408 HIV infected patients who were not exposed to INSTI. Drug resistance mutations (DRMs) were detected among 1.3% of ART-naï ve patients and among 2.7% of INSTI-naï ve patients. The prevalence of 12 polymorphic mutations was significantly different between sub-subtypes A6 and A1. Analysis of the genetic barriers determined two positions in which subtype A (A1 and A6) showed a higher genetic barrier (G140C and V151I) compared with subtype B, and one position in which subtypes A1 and B displayed a higher genetic barrier (L74M and L74I) than sub-subtype A6. Additionally, we confirmed that the L74I mutation was selected at the early stage of the epidemic and subsequently spread as a founder effect in Russia. Our data have added to the overall understanding of the genetic features of sub-subtype A6 in the context of drug resistance. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1999-4915 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afb5e24fc4ff9aba35f560745b1a2edTest https://www.mdpi.com/1999-4915/12/8/838Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1afb5e24fc4ff9aba35f560745b1a2ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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