دورية أكاديمية
Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma
| العنوان: | Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma |
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| المؤلفون: | Gartner Jared J, Davis Sean, Wei Xiaomu, Lin Jimmy C, Trivedi Niraj S, Teer Jamie K, Meltzer Paul S, Rosenberg Steven A, Samuels Yardena |
| المصدر: | BMC Genomics, Vol 13, Iss 1, p 505 (2012) |
| بيانات النشر: | BMC, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Biotechnology LCC:Genetics |
| مصطلحات موضوعية: | Biotechnology, TP248.13-248.65, Genetics, QH426-470 |
| الوصف: | Abstract Background Metastasis is characterized by spreading of neoplastic cells to an organ other than where they originated and is the predominant cause of death among cancer patients. This holds true for melanoma, whose incidence is increasing more rapidly than any other cancer and once disseminated has few therapeutic options. Here we performed whole exome sequencing of two sets of matched normal and metastatic tumor DNAs. Results Using stringent criteria, we evaluated the similarities and differences between the lesions. We find that in both cases, 96% of the single nucleotide variants are shared between the two metastases indicating that clonal populations gave rise to the distant metastases. Analysis of copy number variation patterns of both metastatic sets revealed a trend similar to that seen with our single nucleotide variants. Analysis of pathway enrichment on tumor sets shows commonly mutated pathways enriched between individual sets of metastases and all metastases combined. Conclusions These data provide a proof-of-concept suggesting that individual metastases may have sufficient similarity for successful targeting of driver mutations. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2164 |
| العلاقة: | http://www.biomedcentral.com/1471-2164/13/505Test; https://doaj.org/toc/1471-2164Test |
| DOI: | 10.1186/1471-2164-13-505 |
| الوصول الحر: | https://doaj.org/article/10145d502c744e8d960e6c0f6aa2168eTest |
| رقم الانضمام: | edsdoj.10145d502c744e8d960e6c0f6aa2168e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14712164 |
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| DOI: | 10.1186/1471-2164-13-505 |