المؤلفون: Johnson, Kara L, Qi, Zhijie, Yan, Zhangming, Wen, Xingzhao, Nguyen, Tri C, Zaleta-Rivera, Kathia, Chen, Chien-Ju, Fan, Xiaochen, Sriram, Kiran, Wan, Xueyi, Chen, Zhen Bouman, Zhong, Sheng

المصدر: Molecular Cell. 81(19)

مصطلحات موضوعية: Biological Sciences, Bioinformatics and Computational Biology, Genetics, Human Genome, 2.1 Biological and endogenous factors, Aetiology, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Computational Biology, Databases, Genetic, Female, Gene Expression Profiling, Genes, Lethal, HEK293 Cells, Human Umbilical Vein Endothelial Cells, Humans, Jurkat Cells, Karyopherins, Kidney, Male, Nuclear Matrix-Associated Proteins, Poly (ADP-Ribose) Polymerase-1, Protein Interaction Mapping, Protein Interaction Maps, Proteins, RNA-Binding Proteins, RNA-Seq, Receptors, Cytoplasmic and Nuclear, Software, T-Lymphocytes, Transcription Factors, Transcriptome, beta Karyopherins, Co-immunoprecipitation, Network, PARP1, PROPER-seq, Protein structure, Protein-protein interaction, Proximity ligation assay, SMART-display, Sequencing, Synthetic lethal, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/15c1z1rbTest

المؤلفون: Walker, Janek S, Hing, Zachary A, Harrington, Bonnie, Baumhardt, Jordan, Ozer, Hatice Gulcin, Lehman, Amy, Giacopelli, Brian, Beaver, Larry, Williams, Katie, Skinner, Jordan N, Cempre, Casey B, Sun, Qingxiang, Shacham, Sharon, Stromberg, Benjamin R, Summers, Matthew K, Abruzzo, Lynne V, Rassenti, Laura, Kipps, Thomas J, Parikh, Sameer, Kay, Neil E, Rogers, Kerry A, Woyach, Jennifer A, Coppola, Vincenzo, Chook, Yuh Min, Oakes, Christopher, Byrd, John C, Lapalombella, Rosa

المصدر: Journal of Hematology & Oncology. 14(1)

مصطلحات موضوعية: Rare Diseases, Lymphoma, Cancer, Genetics, Hematology, 2.1 Biological and endogenous factors, Aetiology, Animals, Epigenesis, Genetic, Female, Gene Expression Regulation, Leukemic, Humans, Karyopherins, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Mice, Inbred C57BL, Models, Molecular, Mutation, Receptors, Cytoplasmic and Nuclear, Retrospective Studies, Transcriptome, XPO1, Chronic lymphocytic leukemia, Mouse model, Selinexor, Sines, Expression profiling, Mutation analysis, Cardiorespiratory Medicine and Haematology, Oncology and Carcinogenesis

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9jv0q230Test

المؤلفون: Duncan-Lewis, Christopher, Hartenian, Ella, King, Valeria, Glaunsinger, Britt A

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Genetics, Generic health relevance, Active Transport, Cell Nucleus, Antineoplastic Agents, Apoptosis, Cytoplasm, Feedback, Physiological, Gene Expression Regulation, Neoplastic, HCT116 Cells, HEK293 Cells, HeLa Cells, Humans, Neoplasms, RNA Polymerase II, RNA Stability, RNA, Messenger, RNA, Neoplasm, Time Factors, Transcription, Genetic, alpha Karyopherins, beta Karyopherins, Hela Cells, PNPT1, RNA decay, RNA polymerase II, apoptosis, cell biology, chromosomes, dis3l2, feedback, gene expression, human, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7dh0t873Test

المؤلفون: Zhang, Lianjun, Nguyen, Le Xuan Truong, Chen, Ying-Chieh, Wu, Dijiong, Cook, Guerry J, Hoang, Dinh Hoa, Brewer, Casey J, He, Xin, Dong, Haojie, Li, Shu, Li, Man, Zhao, Dandan, Qi, Jing, Hua, Wei-Kai, Cai, Qi, Carnahan, Emily, Chen, Wei, Wu, Xiwei, Swiderski, Piotr, Rockne, Russell C, Kortylewski, Marcin, Li, Ling, Zhang, Bin, Marcucci, Guido, Kuo, Ya-Huei

المصدر: Nature Communications. 12(1)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Pediatric, Pediatric Cancer, Rare Diseases, Cancer, Biotechnology, Childhood Leukemia, Stem Cell Research, Hematology, Pediatric Research Initiative, Genetics, 2.1 Biological and endogenous factors, Aetiology, Animals, Antineoplastic Agents, Calcium-Binding Proteins, Cell Cycle Proteins, Cell Survival, Chromosome Inversion, Chromosomes, Human, Pair 16, EGF Family of Proteins, GATA2 Transcription Factor, Guanine Nucleotide Exchange Factors, Histone Deacetylases, Humans, Karyopherins, Leukemia, Myeloid, Acute, Mice, MicroRNAs, Molecular Targeted Therapy, Myeloid Progenitor Cells, Neoplastic Stem Cells, Nuclear Proteins, Oncogene Proteins, Fusion, Repressor Proteins, Xenograft Model Antitumor Assays, ran GTP-Binding Protein

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4xm3c5w5Test

المؤلفون: Squires, Katherine E, Gerber, Kyle J, Tillman, Matthew C, Lustberg, Daniel J, Montañez-Miranda, Carolina, Zhao, Meilan, Ramineni, Suneela, Scharer, Christopher D, Saha, Ramendra N, Shu, Feng-Jue, Schroeder, Jason P, Ortlund, Eric A, Weinshenker, David, Dudek, Serena M, Hepler, John R

مصطلحات موضوعية: Basic Behavioral and Social Science, Neurosciences, Behavioral and Social Science, Genetics, 2.1 Biological and endogenous factors, Underpinning research, Aetiology, 1.1 Normal biological development and functioning, Neurological, Animals, Cell Nucleus, Hippocampus, Humans, Karyopherins, Long-Term Potentiation, Mice, Mutation, Neuronal Plasticity, Neurons, Protein Transport, RGS Proteins, Receptors, Cytoplasmic and Nuclear, Signal Transduction, Spatial Learning, G protein, dendritic spine, genetic polymorphism, hippocampus, human genetics, neuron, nuclear receptor, nuclear translocation, regulator of G protein signaling, synaptic plasticity, Chemical Sciences, Biological Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7xb4h01sTest

المؤلفون: Kater, Arnon P, Wu, Jenny Qun, Kipps, Thomas, Eichhorst, Barbara, Hillmen, Peter, D’Rozario, James, Assouline, Sarit, Owen, Carolyn, Robak, Tadeusz, de la Serna, Javier, Jaeger, Ulrich, Cartron, Guillaume, Montillo, Marco, Dubois, Julie, Eldering, Eric, Mellink, Clemens, Van Der Kevie-Kersemaekers, Anne-Marie, Kim, Su Young, Chyla, Brenda, Punnoose, Elizabeth, Bolen, Christopher R, Assaf, Zoe June, Jiang, Yanwen, Wang, Jue, Lefebure, Marcus, Boyer, Michelle, Humphrey, Kathryn, Seymour, John F

المصدر: Journal of Clinical Oncology. 38(34)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Hematology, Clinical Research, Clinical Trials and Supportive Activities, Cancer, Lymphoma, Genetics, Rare Diseases, Good Health and Well Being, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Bridged Bicyclo Compounds, Heterocyclic, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Karyopherins, Leukemia, Lymphocytic, Chronic, B-Cell, Mutation, Progression-Free Survival, Proto-Oncogene Proteins B-raf, Receptor, Notch1, Receptors, Cytoplasmic and Nuclear, Rituximab, Sulfonamides, Treatment Outcome, Tumor Suppressor Protein p53, Clinical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7sh116tcTest

المؤلفون: Bick, Alexander G, Weinstock, Joshua S, Nandakumar, Satish K, Fulco, Charles P, Bao, Erik L, Zekavat, Seyedeh M, Szeto, Mindy D, Liao, Xiaotian, Leventhal, Matthew J, Nasser, Joseph, Chang, Kyle, Laurie, Cecelia, Burugula, Bala Bharathi, Gibson, Christopher J, Niroula, Abhishek, Lin, Amy E, Taub, Margaret A, Aguet, Francois, Ardlie, Kristin, Mitchell, Braxton D, Barnes, Kathleen C, Moscati, Arden, Fornage, Myriam, Redline, Susan, Psaty, Bruce M, Silverman, Edwin K, Weiss, Scott T, Palmer, Nicholette D, Vasan, Ramachandran S, Burchard, Esteban G, Kardia, Sharon LR, He, Jiang, Kaplan, Robert C, Smith, Nicholas L, Arnett, Donna K, Schwartz, David A, Correa, Adolfo, de Andrade, Mariza, Guo, Xiuqing, Konkle, Barbara A, Custer, Brian, Peralta, Juan M, Gui, Hongsheng, Meyers, Deborah A, McGarvey, Stephen T, Chen, Ida Yii-Der, Shoemaker, M Benjamin, Peyser, Patricia A, Broome, Jai G, Gogarten, Stephanie M, Wang, Fei Fei, Wong, Quenna, Montasser, May E, Daya, Michelle, Kenny, Eimear E, North, Kari E, Launer, Lenore J, Cade, Brian E, Bis, Joshua C, Cho, Michael H, Lasky-Su, Jessica, Bowden, Donald W, Cupples, L Adrienne, Mak, Angel CY, Becker, Lewis C, Smith, Jennifer A, Kelly, Tanika N, Aslibekyan, Stella, Heckbert, Susan R, Tiwari, Hemant K, Yang, Ivana V, Heit, John A, Lubitz, Steven A, Johnsen, Jill M, Curran, Joanne E, Wenzel, Sally E, Weeks, Daniel E, Rao, Dabeeru C, Darbar, Dawood, Moon, Jee-Young, Tracy, Russell P, Buth, Erin J, Rafaels, Nicholas, Loos, Ruth JF, Durda, Peter, Liu, Yongmei, Hou, Lifang, Lee, Jiwon, Kachroo, Priyadarshini, Freedman, Barry I, Levy, Daniel, Bielak, Lawrence F, Hixson, James E, Floyd, James S, Whitsel, Eric A, Ellinor, Patrick T, Irvin, Marguerite R, Fingerlin, Tasha E, Raffield, Laura M, Armasu, Sebastian M

المصدر: Nature. 586(7831)

مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Biotechnology, Regenerative Medicine, Stem Cell Research, Human Genome, Underpinning research, Aetiology, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Cardiovascular, Generic health relevance, Inflammatory and immune system, Good Health and Well Being, Adult, Africa, Aged, Aged, 80 and over, Black People, Cell Self Renewal, Clonal Hematopoiesis, DNA-Binding Proteins, Dioxygenases, Female, Genetic Predisposition to Disease, Genome, Human, Germ-Line Mutation, Hematopoietic Stem Cells, Humans, Intracellular Signaling Peptides and Proteins, Male, Middle Aged, National Heart, Lung, and Blood Institute (U.S.), Phenotype, Precision Medicine, Proto-Oncogene Proteins, Tripartite Motif Proteins, United States, Whole Genome Sequencing, alpha Karyopherins, NHLBI Trans-Omics for Precision Medicine Consortium, General Science & Technology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7w16b34nTest

المؤلفون: Hightower, Rylie M, Reid, Andrea L, Gibbs, Devin E, Wang, Yimin, Widrick, Jeffrey J, Kunkel, Louis M, Kastenschmidt, Jenna M, Villalta, S Armando, van Groen, Thomas, Chang, Hua, Gornisiewicz, Savanna, Landesman, Yosef, Tamir, Sharon, Alexander, Matthew S

المصدر: Molecular Therapy. 28(1)

مصطلحات موضوعية: Medical Physiology, Biomedical and Clinical Sciences, Intellectual and Developmental Disabilities (IDD), Rare Diseases, Stem Cell Research - Nonembryonic - Non-Human, Neurosciences, Muscular Dystrophy, Brain Disorders, Duchenne/ Becker Muscular Dystrophy, Pediatric, Stem Cell Research, Aetiology, 2.1 Biological and endogenous factors, Musculoskeletal, Active Transport, Cell Nucleus, Administration, Oral, Animals, Biomarkers, Cytokines, Disease Models, Animal, Karyopherins, Locomotion, Macrophages, Membrane Proteins, Mice, Mice, Inbred DBA, Mice, Inbred mdx, Muscle Proteins, Muscle, Skeletal, Muscular Dystrophy, Duchenne, Mutation, Receptors, Cytoplasmic and Nuclear, Zebrafish, Zebrafish Proteins, CRM1, DMD, KPT-350, SINE, XPO1, muscle inflammation, muscle zebrafish, Biological Sciences, Technology, Medical and Health Sciences, Biotechnology, Genetics, Clinical sciences, Medical biotechnology

الوصول الحر: https://escholarship.org/uc/item/1m96x4d2Test

المؤلفون: Hobbs, Brian D, Putman, Rachel K, Araki, Tetsuro, Nishino, Mizuki, Gudmundsson, Gunnar, Gudnason, Vilmundur, Eiriksdottir, Gudny, Zilhao Nogueira, Nuno Rodrigues, Dupuis, Josée, Xu, Hanfei, O'Connor, George T, Manichaikul, Ani, Nguyen, Jennifer, Podolanczuk, Anna J, Madahar, Purnema, Rotter, Jerome I, Lederer, David J, Barr, R Graham, Rich, Stephen S, Ampleford, Elizabeth J, Ortega, Victor E, Peters, Stephen P, O'Neal, Wanda K, Newell, John D, Bleecker, Eugene R, Meyers, Deborah A, Allen, Richard J, Oldham, Justin M, Ma, Shwu-Fan, Noth, Imre, Jenkins, R Gisli, Maher, Toby M, Hubbard, Richard B, Wain, Louise V, Fingerlin, Tasha E, Schwartz, David A, Washko, George R, Rosas, Ivan O, Silverman, Edwin K, Hatabu, Hiroto, Cho, Michael H, Hunninghake, Gary M

المصدر: American journal of respiratory and critical care medicine. 200(11)

مصطلحات موضوعية: Humans, Lung Diseases, Interstitial, Genetic Predisposition to Disease, beta Karyopherins, TATA Box Binding Protein-Like Proteins, Case-Control Studies, Polymorphism, Single Nucleotide, Aged, Middle Aged, Female, Male, Promoter Regions, Genetic, Idiopathic Pulmonary Fibrosis, Genome-Wide Association Study, Mucin-5B, Genetic Loci, SNP, genetics, genome-wide association study, idiopathic pulmonary fibrosis, interstitial lung abnormalities, Genetics, Lung, Rare Diseases, Chronic Obstructive Pulmonary Disease, Clinical Research, Prevention, Human Genome, Autoimmune Disease, Aging, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Medical and Health Sciences, Respiratory System

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6mb5z7wwTest

المؤلفون: George, Athira, Aubol, Brandon E, Fattet, Laurent, Adams, Joseph A

المصدر: Journal of Biological Chemistry. 294(24)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Genetics, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Amino Acid Sequence, Arginine, Cell Nucleus, HeLa Cells, Humans, Phosphorylation, Protein Conformation, Protein Serine-Threonine Kinases, Protein-Tyrosine Kinases, Sequence Homology, Serine, Serine-Arginine Splicing Factors, Substrate Specificity, beta Karyopherins, phosphorylation, RNA splicing, nuclear translocation, serine, threonine protein kinase, RNA processing, intrinsically disordered protein, post-transcriptional regulation, Arg-Ser repeat, cdc2-like kinase, splicing factor, SR protein, Hela Cells, Arg–Ser repeat, serine/threonine protein kinase, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5696t9zwTest