التفاصيل البيبلوغرافية
| العنوان: |
Racially restricted contribution of immunoglobulin Fcγ and Fcγ receptor genotypes to humoral immunity to human epidermal growth factor receptor 2 in breast cancer. |
| المؤلفون: |
Pandey, J. P., Namboodiri, A. M., Kistner‐Griffin, E., Iwasaki, M., Kasuga, Y., Hamada, G. S., Tsugane, S. |
| المصدر: |
Clinical & Experimental Immunology; Mar2013, Vol. 171 Issue 3, p273-277, 5p |
| مصطلحات موضوعية: |
IMMUNOGLOBULINS, FC receptors, HUMORAL immunity, HER2 protein, BREAST cancer prognosis, ANTIBODY formation, GENETIC markers, ALLELES |
| مستخلص: |
Tumour-associated antigen human epidermal growth factor receptor 2 ( HER2) is over-expressed in 25-30% of breast cancer patients and is associated with poor prognosis. Naturally occurring anti- HER2 antibody responses have been described in patients with HER2 over-expressing tumours. There is significant interindividual variability in antibody responsiveness, but the host genetic factors responsible for this variability are poorly understood. The aim of the present investigation was to determine whether immunoglobulin genetic markers [ GM (genetic determinants of γ chains)] and Fcγ receptor ( Fcγ R) alleles contribute to the magnitude of natural antibody responsiveness to HER2 in patients with breast cancer. A total of 855 breast cancer patients from Japan and Brazil were genotyped for several GM and Fcγ R alleles. They were also characterized for immunoglobulin ( Ig)G antibodies to HER2. In white subjects ( n = 263), GM 23-carriers had higher levels of anti-HER2 antibodies than non-carriers of this allele ( p = 0·004). At the GM 5/21 locus, the homozygotes for the GM 5 allele had higher levels of anti- HER2 antibodies than the other two genotypes ( P = 0·0067). In black subjects ( n = 42), Fcγ RIIa-histidine/histidine homozygotes and Fcγ RIIIa-phenylalanine/valine heterozygotes were associated with high antibody responses ( P = 0·0071 and 0·0275, respectively). Fcγ R genotypes in white subjects and GM genotypes in black subjects were not associated with anti- HER2 antibody responses. No significant associations were found in other study groups. These racially restricted contributions of GM and Fcγ R genotypes to humoral immunity to HER2 have potential implications for immunotherapy of breast cancer. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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