المؤلفون: Sandra Vale, Preeti Joshi, Jill Smith, Dianne E. Campbell

المصدر: Medical Journal of Australia. 210:89-93

مصطلحات موضوعية: Allergy, medicine.medical_specialty, Clinical immunology, Allergy prevention, First year of life, Disease, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Allergy and Immunology, medicine, Humans, 030212 general & internal medicine, Infant feeding, Early onset, Australasia, business.industry, Infant, Newborn, Infant, General Medicine, medicine.disease, Diet, Solid food, Child, Preschool, Family medicine, Practice Guidelines as Topic, Female, Infant Food, business, Food Hypersensitivity

الوصف: INTRODUCTION The Australasian Society of Clinical Immunology and Allergy, the peak professional body for clinical immunology and allergy in Australia and New Zealand, develops and provides information on a wide range of immune-mediated disorders, including advice about infant feeding and allergy prevention for health professionals and families. Guidelines for infant feeding and early onset allergy prevention were published in 2016, with additional guidance published in 2017 and 2018, based on emerging evidence. MAIN RECOMMENDATIONS When the infant is ready, at around 6 months, but not before 4 months, start to introduce a variety of solid foods. (This is not a strict window of introduction but rather a recommendation not to delay the introduction of solid foods beyond 12 months.) Introduce peanut and egg in the first year of life in all infants, regardless of their allergy risk factors. Hydrolysed (partially and extensively) formula is no longer recommended for the prevention of allergic disease. CHANGES IN MANAGEMENT A RESULT OF THE GUIDELINES The guidelines specifically recommend introducing solid foods at around 6 months of age and introducing peanut and egg in the first year of life in all infants to prevent allergy development. Hydrolysed formula is no longer recommended for prevention of allergic disease. A new document outlining the reasons for and the method of peanut introduction to high risk infants is available for health professionals.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592d095a65b7cfbd433c89f1cc68fe5aTest
https://doi.org/10.5694/mja2.12102Test

المؤلفون: Martha Gay, Anita Safronenka, Hong Cao, Robin Tucker, Narayan Shivapurkar, Annie Kruger, Jill Smith

المصدر: Journal of Clinical and Translational Science. 4:93-94

مصطلحات موضوعية: Nonalcoholic steatohepatitis, medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Antagonist, medicine, General Medicine, business, Cholecystokinin receptor, Proinflammatory cytokine, Cholecystokinin

الوصف: OBJECTIVES/GOALS: NASH increases the risk of cirrhosis and liver cancer. High-fat diets increase CCK levels and CCK receptors have been identified on fibroblasts and immune cells. We hypothesized that CCK receptor blockade could prevent NASH by altering the hepatic microenvironment and macrophage activation. METHODS/STUDY POPULATION: Female mice were fed a Choline Deficient Ethionine supplemented (CDE) saturated fat diet or control high-fat diet for 18 weeks. Mice in each group were treated with a CCK receptor antagonist, proglumide (0.1 mg/ml) in the drinking water or regular water. Resected livers were stained for H&E for features of NASH and F4/80 for macrophages analysis. Liver RNA was evaluated for the expression of cytokines and chemokines using an 84-gene Profiler array (Qiagen). Oxidative stress was analyzed by qRT-PCR for heat shock proteins (HSPs) 27, 60, 70 and 90 and for glutathione by a fluorometric assay. Differences in CDE fed and CDE/proglumide-treated mouse livers were evaluated. RESULTS/ANTICIPATED RESULTS: Livers from mice on the CDE diet displayed histologic features of NASH that were prevented by proglumide. Cytokines and chemokines expression, especially CCL20 and CCL2, were increased in the CDE fed mice and these levels were reduced greater than 20-fold with proglumide. Infiltration of F4/80+ macrophages was markedly increased in the CDE livers and these were reduced by > 50% (p < 0.0001) with proglumide. RNA expression of HSP70 (p = 0.006) and HSP27 (p = 0.011) were reduced with proglumide. Hepatic glutathione concentration more than doubled in the CDE/proglumide treated mice compared to CDE mice. CCK-B receptor expression increased in the CDE-fed mouse livers compared to controls. DISCUSSION/SIGNIFICANCE OF IMPACT: CCK receptor blockade decreases NASH by reducing hepatic macrophages, oxidative stress, and blocking inflammatory cytokines and chemokines. This data supports our novel hypothesis that CCK receptors play a role in NASH and proglumide may provide an innovative treatment for this condition.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::03d164992e80fb0456a22ea22ffd095eTest
https://doi.org/10.1017/cts.2020.293Test

المؤلفون: Jill Smith, David Bone, John Wheeler

المصدر: Clinical Child Psychology and Psychiatry. 6:605-608

مصطلحات موضوعية: Psychiatry and Mental health, Clinical Psychology, Order (business), Pediatrics, Perinatology and Child Health, General Medicine, Sociology, Criminology, Mathematical economics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e38e28c0bcecce3e3c58b4d137310183Test
https://doi.org/10.1177/1359104501006004017Test

المؤلفون: David Bone, John Wheeler, Jill Smith

المصدر: Clinical Child Psychology and Psychiatry. 3:169-181

مصطلحات موضوعية: business.industry, 05 social sciences, Applied psychology, Attendance, Post modernism, General Medicine, 030227 psychiatry, Variety (cybernetics), 03 medical and health sciences, Psychiatry and Mental health, Clinical Psychology, 0302 clinical medicine, Child protection, Multidisciplinary approach, Completion rate, Pediatrics, Perinatology and Child Health, Relevance (law), Medicine, 0501 psychology and cognitive sciences, Adaptation (computer science), business, Social psychology, 050104 developmental & child psychology

الوصف: Practitioners in child mental settings are often faced with complex demands when asked to assess multi-problem families; all the more so when their conclusions and recommendations are likely to have a major impact on subsequent decisions in court. Over time, the authors have developed a model of assessment which effectively encapsulates the demand for comprehensiveness, relevance and fairness, incorporates a rich variety of individual and systemic approaches, leads to a high attendance and completion rate, and goes some way to addressing current post-modernist challenges. While the model is closely calibrated to our own skills and beliefs, we are confident that the design easily allows for adaptation by other teams faced with similar demands.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6da0952a7a2a57aa5174c92c3bd3d4e8Test
https://doi.org/10.1177/1359104598032003Test

المؤلفون: Ronald J. Quinn, Jill Smith, Anthony R. Carroll, Sylvia Urban, Priscila de Almeida Leone, Gregory Allen Fechner, John N. A. Hooper

المصدر: ChemInform. 30

مصطلحات موضوعية: Sponge, chemistry.chemical_compound, biology, chemistry, Stereochemistry, Axinella, Imidazole, General Medicine, biology.organism_classification

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::17bef043f74c3d4200364320af4f6eeaTest
https://doi.org/10.1002/chin.199927231Test

المؤلفون: Paul I. Forster, Gordon P. Guymer, Edward G. Hyde, Ronald J. Quinn, Anthony R. Carroll, Jill Smith

المصدر: ChemInform. 36

مصطلحات موضوعية: Actinophyllic acid, Carboxypeptidase B2, Carboxypeptidase U, Stereochemistry, Carboxylic acid, Amidohydrolases, Indole Alkaloids, Hippuricase, Enzyme Inhibitors, Alstonia, chemistry.chemical_classification, Aminoacylase, biology, Indole alkaloid, Apocynaceae, Chemistry, Alkaloid, Organic Chemistry, General Medicine, biology.organism_classification, Enzyme assay, Plant Leaves, Enzyme, Biochemistry, biology.protein, Biological Assay, Two-dimensional nuclear magnetic resonance spectroscopy

الوصف: Bioassay-guided fractionation of the aqueous extract of the leaves of Alstonia actinophylla with use of a coupled enzyme assay, CPU/hippuricase, to detect carboxypeptidase U inhibitors led to the isolation of a novel indole alkaloid, actinophyllic acid (1). The structure of 1 was determined from detailed 2D NMR studies. Actinophyllic acid was found to be a potent inhibitor of the coupled enzyme assay with an IC(50) of 0.84 microM. Actinophyllic acid possesses a unique 2,3,6,7,9,13c-hexahydro-1H-1,7,8-(methanetriyloxymethano)pyrrolo[1',2':1,2]azocino[4,3-b]indole-8(5H)-carboxylic acid skeleton.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda9f4c5f749dab153cb8871e0a9755fTest
https://doi.org/10.1002/chin.200526137Test

المؤلفون: John Whitfield, D. Mascord, Jill Smith, Graham A. Starmer

المصدر: Alcohol and Alcoholism.

مصطلحات موضوعية: medicine.medical_specialty, Ethanol, Plasma samples, Fructose, Alcohol, General Medicine, Metabolism, Carbohydrate, chemistry.chemical_compound, Endocrinology, chemistry, Biochemistry, Internal medicine, medicine, Ethanol metabolism

الوصف: Plasma acetate concentration is increased during alcohol metabolism. However, measures which increase the rate of alcohol metabolism do not always increase plasma acetate concentration. Plasma samples from normal male subjects who had been given alcohol and then either fructose or glucose were analysed for acetate. Although each of these carbohydrates increased the mean rate of alcohol metabolism, only fructose increased the plasma acetate concentration. It was concluded that the further metabolism of acetate produced from alcohol may be increased by glucose.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::855b18087e74eacbdeff54f9b95f7ff6Test
https://doi.org/10.1093/oxfordjournals.alcalc.a045189Test

المؤلفون: D. Mascord, John Whitfield, Graham A. Starmer, Jill Smith

المصدر: Europe PubMed Central

مصطلحات موضوعية: Adult, Blood Glucose, Male, medicine.medical_specialty, Rate of infusion, Administration, Oral, chemistry.chemical_compound, Oral administration, Internal medicine, Infusion Procedure, medicine, Humans, Insulin, Ethanol metabolism, Infusions, Intravenous, Ethanol, General Medicine, Metabolism, Glucose Tolerance Test, Middle Aged, Carbohydrate, Glucose, Endocrinology, chemistry, Toxicity

الوصف: We have tested whether the effect of carbohydrate on the rate of alcohol metabolism can be reproduced by glucose alone. Ten male subjects were given ethanol by intravenous infusion until a steady state was established and 100 g glucose in solution was then taken orally. The rate of alcohol metabolism, measured as the rate of infusion required to maintain a constant breath alcohol reading, increased significantly after glucose but there were differences between the subjects. The presence or absence of a change in the rate of alcohol metabolism after glucose was associated with the subject's fasting rate and with their glucose tolerance.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7212b2c390308ca712d002c0a962157fTest
https://doi.org/10.1093/oxfordjournals.alcalc.a044830Test

المؤلفون: Frank Tupper Smith, Jill Smith

المصدر: Journal of Clinical Child Psychology. 5:43-45

مصطلحات موضوعية: Exceptional Child, Law, General Medicine, Psychology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c4d1c68d8caeea9d0d9f9d851413a873Test
https://doi.org/10.1080/15374417609532711Test

المؤلفون: Beed, Jill Smith

المصدر: Mayo Clinic Proceedings ; volume 59, issue 2, page 129-130 ; ISSN 0025-6196

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/s0025-6196Test(12)60254-7
https://api.elsevier.com/content/article/PII:S0025619612602547?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0025619612602547?httpAccept=text/plainTest